Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates
OBJECTIVE: Fetal liver is mostly perfused by umbilical vein via ductus venosus and AFP is synthesized and secreted from fetal liver. In this study we tried to determine the effect of ductus venosus and umbilical blood flow on serum AFP levels STUDY DESIGN: Sixty women with 16-20 weeks of gestation...
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Medical Network
2013-12-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/208 |
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| author | Alptekin Tosun Enis Özkaya Vakkas Korkmaz Yasemin Çekmez |
| author_facet | Alptekin Tosun Enis Özkaya Vakkas Korkmaz Yasemin Çekmez |
| author_sort | Alptekin Tosun |
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OBJECTIVE: Fetal liver is mostly perfused by umbilical vein via ductus venosus and AFP is synthesized and secreted from fetal liver. In this study we tried to determine the effect of ductus venosus and umbilical blood flow on serum AFP levels
STUDY DESIGN: Sixty women with 16-20 weeks of gestation were enrolled for the study. Subjects were divided into two: AFP levels lower (n=46) and higher than 2 MomS MoMs (n=14). All participants underwent serum AFP, ductus venosus and umbilical artery Doppler Doppler S/D screening. Effect of ductus venosus and umbilical artery blood flow on serum AFP levels were analyzed.
RESULTS: Ductus venosus (AUC=0.945, P<0.001) and umbilical artery Doppler S/D (AUC=0.803, P=0.001) values were predictor for low AFP levels. In regression analysis, Ductus venosus Doppler S/D (Beta coefficient= -0.442, P<0.001) and umbilical artery S/D (Beta coefficient= -0.291, P=0.011) values were significantly associated with the AFP levels (R2=0.60). DV and umbilical artery Doppler S/D values adjusted serum AFP levels remained significant but mean value of AFP in group with AFP>2 MoM became 1.98 MoM after adjustment.
CONCLUSION: Our study revealed that Ductus venosus and umbilical artery S/D value adjusted serum AFP levels may have lower false positive rates.
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| format | Article |
| id | doaj-art-9f57863b162d4d46bb4b0c321e88e6c7 |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2013-12-01 |
| publisher | Medical Network |
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| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-9f57863b162d4d46bb4b0c321e88e6c72025-02-11T21:22:20ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182013-12-01193146Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive RatesAlptekin Tosun0Enis Özkaya1Vakkas Korkmaz2Yasemin Çekmez3Giresun University School of Medicine, Department of Radiology, GiresunGiresun University School of Medicine, Department of Obstetrics and Gynecology, GiresunDr. Sami Ulus Maternity and Children’s Health Teaching and Research, Department of Obstetrics and Gynecology, AnkaraDr. Sami Ulus Maternity and Children’s Health Teaching and Research, Department of Obstetrics and Gynecology, Ankara OBJECTIVE: Fetal liver is mostly perfused by umbilical vein via ductus venosus and AFP is synthesized and secreted from fetal liver. In this study we tried to determine the effect of ductus venosus and umbilical blood flow on serum AFP levels STUDY DESIGN: Sixty women with 16-20 weeks of gestation were enrolled for the study. Subjects were divided into two: AFP levels lower (n=46) and higher than 2 MomS MoMs (n=14). All participants underwent serum AFP, ductus venosus and umbilical artery Doppler Doppler S/D screening. Effect of ductus venosus and umbilical artery blood flow on serum AFP levels were analyzed. RESULTS: Ductus venosus (AUC=0.945, P<0.001) and umbilical artery Doppler S/D (AUC=0.803, P=0.001) values were predictor for low AFP levels. In regression analysis, Ductus venosus Doppler S/D (Beta coefficient= -0.442, P<0.001) and umbilical artery S/D (Beta coefficient= -0.291, P=0.011) values were significantly associated with the AFP levels (R2=0.60). DV and umbilical artery Doppler S/D values adjusted serum AFP levels remained significant but mean value of AFP in group with AFP>2 MoM became 1.98 MoM after adjustment. CONCLUSION: Our study revealed that Ductus venosus and umbilical artery S/D value adjusted serum AFP levels may have lower false positive rates. https://gorm.com.tr/index.php/GORM/article/view/208Ductus venosus dopplerAlfa fetoproteinSecond trimester screening |
| spellingShingle | Alptekin Tosun Enis Özkaya Vakkas Korkmaz Yasemin Çekmez Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates Gynecology Obstetrics & Reproductive Medicine Ductus venosus doppler Alfa fetoprotein Second trimester screening |
| title | Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates |
| title_full | Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates |
| title_fullStr | Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates |
| title_full_unstemmed | Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates |
| title_short | Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates |
| title_sort | ductus venosus doppler s d value adjusted alfa fetoprotein levels to decrease false positive rates |
| topic | Ductus venosus doppler Alfa fetoprotein Second trimester screening |
| url | https://gorm.com.tr/index.php/GORM/article/view/208 |
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