Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation

Prognostic impact of donor mitochondrial genomic variants in myelodysplastic neoplasms after stem-cell transplantation

Abstract Mitochondrial DNA (mtDNA) variants in patients with myelodysplastic neoplasms (MDS) are shown to be prognostic of outcomes after allogeneic hematopoietic cell transplantation (allo-HCT). However, the prognostic impact of donor mtDNA variants is unknown. Here, we performed whole-genome seque...

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Main Authors: Jing Dong, Shahram Arsang-Jang, Tao Zhang, Zhongyuan Chen, Yung-Tsi Bolon, Stephen Spellman, Raul Urrutia, Paul Auer, Wael Saber
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Hematology & Oncology
Online Access:https://doi.org/10.1186/s13045-024-01622-w
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