Chronic pancreatitis: issues remain unresolved
Key points. Article is devoted to one of the major syndromes of chronic pancreatitis — exocrine pancreatic insufficiency. Clinical symptoms of exocrine insufficiency: diarrhea with steatorrhea and flatulence are nonspecific and inconsistent. Laboratory diagnostics nowadays in our country is based on...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2015-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1027 |
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| author | V. T. Ivashkin K. V. Ivashkin A. V. Okhlobystin |
| author_facet | V. T. Ivashkin K. V. Ivashkin A. V. Okhlobystin |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Key points. Article is devoted to one of the major syndromes of chronic pancreatitis — exocrine pancreatic insufficiency. Clinical symptoms of exocrine insufficiency: diarrhea with steatorrhea and flatulence are nonspecific and inconsistent. Laboratory diagnostics nowadays in our country is based on a single method — pancreatic elastase stool test which has low sensitivity and specificity, moreover it is characterized by low reproducibility. Thus, in practical situation it is reasonable to control both severity of disorders of pancreatic secretion, and efficacy of enzyme replacement therapy according to scores of trophological status of the patient both clinical (BMI), and laboratory (serum levels of prealbumin, retinol-binding protein, cholesterol, magnesium). Treatment should include high dose microgranulated enzymes in the form of capsules (the starting dose should be no less than 40 U of lipolytic activity per meal) as well as proton pump inhibitors. Replacement treatment should be life-long. |
| format | Article |
| id | doaj-art-a13e717c6fc948809b383fd81c466c26 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-a13e717c6fc948809b383fd81c466c262025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-09-01254614632Chronic pancreatitis: issues remain unresolvedV. T. Ivashkin0K. V. Ivashkin1A. V. Okhlobystin2«Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation«Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian Federation«Sechenov First Moscow state medical university», Ministry of Healthcare of the Russian FederationKey points. Article is devoted to one of the major syndromes of chronic pancreatitis — exocrine pancreatic insufficiency. Clinical symptoms of exocrine insufficiency: diarrhea with steatorrhea and flatulence are nonspecific and inconsistent. Laboratory diagnostics nowadays in our country is based on a single method — pancreatic elastase stool test which has low sensitivity and specificity, moreover it is characterized by low reproducibility. Thus, in practical situation it is reasonable to control both severity of disorders of pancreatic secretion, and efficacy of enzyme replacement therapy according to scores of trophological status of the patient both clinical (BMI), and laboratory (serum levels of prealbumin, retinol-binding protein, cholesterol, magnesium). Treatment should include high dose microgranulated enzymes in the form of capsules (the starting dose should be no less than 40 U of lipolytic activity per meal) as well as proton pump inhibitors. Replacement treatment should be life-long.https://www.gastro-j.ru/jour/article/view/1027chronic pancreatitisexocrine pancreatic insufficiencypancreas |
| spellingShingle | V. T. Ivashkin K. V. Ivashkin A. V. Okhlobystin Chronic pancreatitis: issues remain unresolved Российский журнал гастроэнтерологии, гепатологии, колопроктологии chronic pancreatitis exocrine pancreatic insufficiency pancreas |
| title | Chronic pancreatitis: issues remain unresolved |
| title_full | Chronic pancreatitis: issues remain unresolved |
| title_fullStr | Chronic pancreatitis: issues remain unresolved |
| title_full_unstemmed | Chronic pancreatitis: issues remain unresolved |
| title_short | Chronic pancreatitis: issues remain unresolved |
| title_sort | chronic pancreatitis issues remain unresolved |
| topic | chronic pancreatitis exocrine pancreatic insufficiency pancreas |
| url | https://www.gastro-j.ru/jour/article/view/1027 |
| work_keys_str_mv | AT vtivashkin chronicpancreatitisissuesremainunresolved AT kvivashkin chronicpancreatitisissuesremainunresolved AT avokhlobystin chronicpancreatitisissuesremainunresolved |