Cell migration in dense microenvironments
The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular...
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| Format: | Article |
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Académie des sciences
2023-09-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.124/ |
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| author | de Freitas Nader, Guilherme Pedreira García-Arcos, Juan Manuel |
| author_facet | de Freitas Nader, Guilherme Pedreira García-Arcos, Juan Manuel |
| author_sort | de Freitas Nader, Guilherme Pedreira |
| collection | DOAJ |
| description | The nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense interstitial spaces, the nuclear envelope folds stretch, increasing nuclear envelope tension and sometimes causing rupture. Different degrees of nuclear envelope tension regulate cellular behaviors and functions, especially in cells that move and grow within dense matrices. The crosstalk between extracellular mechanical inputs and the cell nucleus is a critical component in the modulation of cell function of cells that navigate within packed microenvironments. Moreover, there is a link between regimes of nuclear envelope unfolding and different cellular behaviors, from orchestrated signaling cascades to cellular perturbations and damage. |
| format | Article |
| id | doaj-art-a1bb9d5fd64a41ea8d93e7fed3650a66 |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-a1bb9d5fd64a41ea8d93e7fed3650a662025-02-07T10:37:08ZengAcadémie des sciencesComptes Rendus Biologies1768-32382023-09-01346G2899310.5802/crbiol.12410.5802/crbiol.124Cell migration in dense microenvironmentsde Freitas Nader, Guilherme Pedreira0https://orcid.org/0000-0002-1905-1903García-Arcos, Juan Manuel1https://orcid.org/0000-0003-3420-6093Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia and Perelman School of Medicine, University of Pennsylvania, 3615 Civic Center Boulevard, Abramson Research Center, Philadelphia, PA 19104-4399, USADepartment of Biochemistry, University of Geneva, CH-1205 Geneva, SwitzerlandThe nucleus has been viewed as a passenger during cell migration that functions merely to protect the genome. However, increasing evidence shows that the nucleus is an active organelle, constantly sensing the surrounding environment and translating extracellular mechanical inputs into intracellular signaling. The nuclear envelope has a large membrane reservoir which serves as a buffer for mechanical inputs as it unfolds without increasing its tension. In contrast, when cells cope with mechanical strain, such as migration through solid tumors or dense interstitial spaces, the nuclear envelope folds stretch, increasing nuclear envelope tension and sometimes causing rupture. Different degrees of nuclear envelope tension regulate cellular behaviors and functions, especially in cells that move and grow within dense matrices. The crosstalk between extracellular mechanical inputs and the cell nucleus is a critical component in the modulation of cell function of cells that navigate within packed microenvironments. Moreover, there is a link between regimes of nuclear envelope unfolding and different cellular behaviors, from orchestrated signaling cascades to cellular perturbations and damage.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.124/Cell migrationNucleusNuclear envelope |
| spellingShingle | de Freitas Nader, Guilherme Pedreira García-Arcos, Juan Manuel Cell migration in dense microenvironments Comptes Rendus Biologies Cell migration Nucleus Nuclear envelope |
| title | Cell migration in dense microenvironments |
| title_full | Cell migration in dense microenvironments |
| title_fullStr | Cell migration in dense microenvironments |
| title_full_unstemmed | Cell migration in dense microenvironments |
| title_short | Cell migration in dense microenvironments |
| title_sort | cell migration in dense microenvironments |
| topic | Cell migration Nucleus Nuclear envelope |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.124/ |
| work_keys_str_mv | AT defreitasnaderguilhermepedreira cellmigrationindensemicroenvironments AT garciaarcosjuanmanuel cellmigrationindensemicroenvironments |