Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome
BackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS a...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1233145/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856518169100288 |
|---|---|
| author | Zhixiao Xu Xiong Lei Weiwei Chu Luoqi Weng Chengshui Chen Chengshui Chen Chengshui Chen Ran Ye |
| author_facet | Zhixiao Xu Xiong Lei Weiwei Chu Luoqi Weng Chengshui Chen Chengshui Chen Chengshui Chen Ran Ye |
| author_sort | Zhixiao Xu |
| collection | DOAJ |
| description | BackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts.ObjectiveWe worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients.MethodsA total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.ResultsAfter multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend < 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity.ConclusionsAn inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles. |
| format | Article |
| id | doaj-art-a1f263b327ea48ff897794357ee972de |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj-art-a1f263b327ea48ff897794357ee972de2025-02-12T07:32:29ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.12331451233145Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndromeZhixiao Xu0Xiong Lei1Weiwei Chu2Luoqi Weng3Chengshui Chen4Chengshui Chen5Chengshui Chen6Ran Ye7Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The Lu’an People’s Hospital of Anhui Province, The Lu’an Hospital Affiliated to Anhui Medical University, Lu’an, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaKey Laboratory of Interventional Pulmonology of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, ChinaThe Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, ChinaDepartment of Ultrasonography, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaBackgroundThe oxidative balance score (OBS), an encompassing scoring mechanism for assessing oxidative stress, is formulated based on nutritional and lifestyle components. The emergence of metabolic syndrome (MetS) is intricately linked to oxidative stress. Nonetheless, the correlation between OBS and MetS displays variability within distinct cohorts.ObjectiveWe worked on the relationships between OBS and the risk of MetS, MetS severity, and all-cause mortality of MetS patients.MethodsA total of 11,171 adult participants were collected from the U.S. National Health Examination Survey (NHANES) 2007-2018. Employing survey-weighted logistic models, we evaluated the relationship between OBS and MetS risk. Furthermore, survey-weighted linear models were utilized to investigate the connection between OBS and MetS severity. Among the participants, 3,621 individuals had their survival status recorded, allowing us to employ Cox proportional hazards regression models in order to ascertain the association between OBS and the all-cause mortality within the subset of individuals with MetS. The OBS (where a higher OBS signified an increased prevalence of anti- or pro-oxidant exposures) weighed the 20 factors, while the MetS severity score weighed the five factors.ResultsAfter multivariable adjustment, individuals with elevated OBS were found to exhibit a decreased susceptibility to MetS [odds ratio (OR) 0.95; 95% CI 0.94-0.96]. The adjusted OR was 0.42 (95% CI 0.33-0.53) for MetS risk in the fourth OBS quartile compared with those in the first OBS quartile (P for trend < 0.001). A one-unit increase in OBS was linked to a 3% reduction in MetS severity score by 3% (mean difference, -0.03; 95% CI, -0.04 to -0.03). Moreover, increased OBS correlated with decreased hazard of all-cause mortality risk among MetS subjects (adjusted hazard ratio, 0.95; 95% CI, 0.93-0.98). These associations retained their strength even subsequent to the introduction of sensitivity analyses. There existed a statistically significant negative correlation between diet/lifestyle OBS and both MetS risk as well as MetS severity.ConclusionsAn inverse correlation was observed between OBS and the susceptibility to MetS, MetS severity, and all-cause mortality of MetS patients. Health outcomes for MetS patients were positively related to antioxidant diets and lifestyles.https://www.frontiersin.org/articles/10.3389/fendo.2023.1233145/fulloxidative stressmetabolic syndromelifestylesdietmortality |
| spellingShingle | Zhixiao Xu Xiong Lei Weiwei Chu Luoqi Weng Chengshui Chen Chengshui Chen Chengshui Chen Ran Ye Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome Frontiers in Endocrinology oxidative stress metabolic syndrome lifestyles diet mortality |
| title | Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome |
| title_full | Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome |
| title_fullStr | Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome |
| title_full_unstemmed | Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome |
| title_short | Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome |
| title_sort | oxidative balance score was negatively associated with the risk of metabolic syndrome metabolic syndrome severity and all cause mortality of patients with metabolic syndrome |
| topic | oxidative stress metabolic syndrome lifestyles diet mortality |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1233145/full |
| work_keys_str_mv | AT zhixiaoxu oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT xionglei oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT weiweichu oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT luoqiweng oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT chengshuichen oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT chengshuichen oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT chengshuichen oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome AT ranye oxidativebalancescorewasnegativelyassociatedwiththeriskofmetabolicsyndromemetabolicsyndromeseverityandallcausemortalityofpatientswithmetabolicsyndrome |