Race as a prognostic factor of breast mucinous carcinoma
Abstract Purpose The rarity of breast mucinous carcinoma (BMC) makes it challenging to study the prognosis of this disease across diverse racial populations. This study aimed to leverage epidemiological data on immigrant populations to elucidate the prognostic differences in BMC patients from variou...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Journal of Cancer Research and Clinical Oncology |
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| Online Access: | https://doi.org/10.1007/s00432-024-06035-3 |
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| author | Dingyuan Wang Yang Wang Songlin Gao Rongshou Zheng Guijian Wu Jianping Wang Can Lu Kena Bu Chun Zhang Wanqing Chen Bailin Zhang |
| author_facet | Dingyuan Wang Yang Wang Songlin Gao Rongshou Zheng Guijian Wu Jianping Wang Can Lu Kena Bu Chun Zhang Wanqing Chen Bailin Zhang |
| author_sort | Dingyuan Wang |
| collection | DOAJ |
| description | Abstract Purpose The rarity of breast mucinous carcinoma (BMC) makes it challenging to study the prognosis of this disease across diverse racial populations. This study aimed to leverage epidemiological data on immigrant populations to elucidate the prognostic differences in BMC patients from various racial/ethnic backgrounds. The goal was to help formulate more personalized clinical practice guidelines for the management of this rare malignancy. Methods The study included 208 BMC patients from China and 10,322 BMC patients from the SEER database. Clinicopathological data, treatment information, and survival outcomes were compared across different racial/ethnic groups using statistical analyses. Results Asian American BMC patients were younger at diagnosis and had more favorable tumor grade and stage compared to other racial groups. After adjusting for clinicopathological factors and treatments, Asian American BMC patients exhibited significantly better overall survival (OS) than black (HR = 1.53, 95% CI: 1.05–2.22, P = 0.027) and white patients (HR = 1.41, 95% CI: 1.03–1.94, P < 0.001). Specifically, non-Chinese American patients had a worse OS compared to Chinese patients (adjusted HR = 2.59, 95% CI: 1.15–5.83, P = 0.022). Chemotherapy significantly improved OS only in black BMC patients (adjusted HR = 0.52, 95% CI: 0.27–0.98, p = 0.045), but not in other racial/ethnic groups. Conclusion Race is an independent prognostic factor for BMC. Compared with Chinese patients, black and white American patients have a worse prognosis in terms of OS. Treatment guidelines for BMC patients should be formulated with considerations of race factors. For patients with BMC originating from China, a more conservative treatment approach may be warranted. |
| format | Article |
| id | doaj-art-a1fa7976149d47959fc45c1d86244ef7 |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-a1fa7976149d47959fc45c1d86244ef72025-02-09T12:10:30ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352024-12-0115111810.1007/s00432-024-06035-3Race as a prognostic factor of breast mucinous carcinomaDingyuan Wang0Yang Wang1Songlin Gao2Rongshou Zheng3Guijian Wu4Jianping Wang5Can Lu6Kena Bu7Chun Zhang8Wanqing Chen9Bailin Zhang10Department of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeThe VIPII Gastrointestinal Cancer Division of the Medical Department, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and InstituteNational Office for Cancer Prevention and Control & National Central Cancer Registry, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeGeneral Surgery, Ganzhou Nankang First People’s HospitalDepartment of General Surgery, Xiyuan Hospital Chinese Academy of Traditional Chinese MedicineDepartment of Breast Surgery, Beijing Daxing District Maternal and Child Health HospitalDepartment of Breast Surgery, Yulin Xingyuan HospitalDepartment of Breast Surgery, Peking University International HospitalNational Office for Cancer Prevention and Control & National Central Cancer Registry, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Breast Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Purpose The rarity of breast mucinous carcinoma (BMC) makes it challenging to study the prognosis of this disease across diverse racial populations. This study aimed to leverage epidemiological data on immigrant populations to elucidate the prognostic differences in BMC patients from various racial/ethnic backgrounds. The goal was to help formulate more personalized clinical practice guidelines for the management of this rare malignancy. Methods The study included 208 BMC patients from China and 10,322 BMC patients from the SEER database. Clinicopathological data, treatment information, and survival outcomes were compared across different racial/ethnic groups using statistical analyses. Results Asian American BMC patients were younger at diagnosis and had more favorable tumor grade and stage compared to other racial groups. After adjusting for clinicopathological factors and treatments, Asian American BMC patients exhibited significantly better overall survival (OS) than black (HR = 1.53, 95% CI: 1.05–2.22, P = 0.027) and white patients (HR = 1.41, 95% CI: 1.03–1.94, P < 0.001). Specifically, non-Chinese American patients had a worse OS compared to Chinese patients (adjusted HR = 2.59, 95% CI: 1.15–5.83, P = 0.022). Chemotherapy significantly improved OS only in black BMC patients (adjusted HR = 0.52, 95% CI: 0.27–0.98, p = 0.045), but not in other racial/ethnic groups. Conclusion Race is an independent prognostic factor for BMC. Compared with Chinese patients, black and white American patients have a worse prognosis in terms of OS. Treatment guidelines for BMC patients should be formulated with considerations of race factors. For patients with BMC originating from China, a more conservative treatment approach may be warranted.https://doi.org/10.1007/s00432-024-06035-3Breast cancerBreast mucinous carcinomaRaceEthnicityPrognosis |
| spellingShingle | Dingyuan Wang Yang Wang Songlin Gao Rongshou Zheng Guijian Wu Jianping Wang Can Lu Kena Bu Chun Zhang Wanqing Chen Bailin Zhang Race as a prognostic factor of breast mucinous carcinoma Journal of Cancer Research and Clinical Oncology Breast cancer Breast mucinous carcinoma Race Ethnicity Prognosis |
| title | Race as a prognostic factor of breast mucinous carcinoma |
| title_full | Race as a prognostic factor of breast mucinous carcinoma |
| title_fullStr | Race as a prognostic factor of breast mucinous carcinoma |
| title_full_unstemmed | Race as a prognostic factor of breast mucinous carcinoma |
| title_short | Race as a prognostic factor of breast mucinous carcinoma |
| title_sort | race as a prognostic factor of breast mucinous carcinoma |
| topic | Breast cancer Breast mucinous carcinoma Race Ethnicity Prognosis |
| url | https://doi.org/10.1007/s00432-024-06035-3 |
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