Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis
Abstract Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the development of atherosclerosis. Key metabolites and enzymes in sphingolipid metaboli...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Cellular & Molecular Biology Letters |
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| Online Access: | https://doi.org/10.1186/s11658-024-00679-2 |
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| author | Fufangyu Zhao Mingyan Shao Mingrui Li Tianxing Li Yanfei Zheng Wenlong Sun Cheng Ni Lingru Li |
| author_facet | Fufangyu Zhao Mingyan Shao Mingrui Li Tianxing Li Yanfei Zheng Wenlong Sun Cheng Ni Lingru Li |
| author_sort | Fufangyu Zhao |
| collection | DOAJ |
| description | Abstract Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the development of atherosclerosis. Key metabolites and enzymes in sphingolipid metabolism influence the pathogenesis of atherosclerosis in a variety of ways, including inflammatory responses and oxidative stress. Thus, an investigation of sphingolipid metabolism-related metabolites and key enzymes may provide novel insights and treatment targets for atherosclerosis. This review discusses various mechanisms and research progress on the relationship between various sphingolipid metabolites, related enzymes, and atherosclerosis. Finally, we look into the future research direction of phytosphingolipids. Graphical Abstract |
| format | Article |
| id | doaj-art-a1ffecf745f54827921bf710c463459e |
| institution | Kabale University |
| issn | 1689-1392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cellular & Molecular Biology Letters |
| spelling | doaj-art-a1ffecf745f54827921bf710c463459e2025-02-09T12:46:34ZengBMCCellular & Molecular Biology Letters1689-13922025-02-0130112410.1186/s11658-024-00679-2Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosisFufangyu Zhao0Mingyan Shao1Mingrui Li2Tianxing Li3Yanfei Zheng4Wenlong Sun5Cheng Ni6Lingru Li7National Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese MedicineNational Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese MedicineNational Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese MedicineNational Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese MedicineNational Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese MedicineInstitute of Biomedical Research, School of Life Sciences, Shandong University of TechnologySchool of Traditional Chinese Medicine, Beijing University of Chinese MedicineNational Institute of Traditional Chinese Medicine Constitution and Preventive Medicine, Beijing University of Chinese MedicineAbstract Atherosclerosis, with its complex pathogenesis, is a leading underlying cause of many cardiovascular diseases, which are increasingly prevalent in the population. Sphingolipids play an important role in the development of atherosclerosis. Key metabolites and enzymes in sphingolipid metabolism influence the pathogenesis of atherosclerosis in a variety of ways, including inflammatory responses and oxidative stress. Thus, an investigation of sphingolipid metabolism-related metabolites and key enzymes may provide novel insights and treatment targets for atherosclerosis. This review discusses various mechanisms and research progress on the relationship between various sphingolipid metabolites, related enzymes, and atherosclerosis. Finally, we look into the future research direction of phytosphingolipids. Graphical Abstracthttps://doi.org/10.1186/s11658-024-00679-2SphingolipidsPhytosphingolipidsAtherosclerosisMetabolitesEnzymes |
| spellingShingle | Fufangyu Zhao Mingyan Shao Mingrui Li Tianxing Li Yanfei Zheng Wenlong Sun Cheng Ni Lingru Li Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis Cellular & Molecular Biology Letters Sphingolipids Phytosphingolipids Atherosclerosis Metabolites Enzymes |
| title | Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis |
| title_full | Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis |
| title_fullStr | Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis |
| title_full_unstemmed | Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis |
| title_short | Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis |
| title_sort | sphingolipid metabolites involved in the pathogenesis of atherosclerosis perspectives on sphingolipids in atherosclerosis |
| topic | Sphingolipids Phytosphingolipids Atherosclerosis Metabolites Enzymes |
| url | https://doi.org/10.1186/s11658-024-00679-2 |
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