Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions
Abstract Owing to limited data on the optimal timing of rotational atherectomy (RA), we sought to evaluate the clinical impact of the early application of the RA strategy. Consecutive patients with severe coronary artery calcification were enrolled, who underwent percutaneous coronary intervention (...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88695-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862326203252736 |
|---|---|
| author | Kyusup Lee Ji-hoon Jung Woojin Kwon Dae-Won Kim Mahn-Won Park Ik Jun Choi Jae-Hwan Lee Yong Hoon Yoon Jang Hoon Lee Sang Rok Lee Pil Hyung Lee Seung-Whan Lee Ki Dong Yoo Kyeong Ho Yun Hyun-Jong Lee Sung-Ho Her |
| author_facet | Kyusup Lee Ji-hoon Jung Woojin Kwon Dae-Won Kim Mahn-Won Park Ik Jun Choi Jae-Hwan Lee Yong Hoon Yoon Jang Hoon Lee Sang Rok Lee Pil Hyung Lee Seung-Whan Lee Ki Dong Yoo Kyeong Ho Yun Hyun-Jong Lee Sung-Ho Her |
| author_sort | Kyusup Lee |
| collection | DOAJ |
| description | Abstract Owing to limited data on the optimal timing of rotational atherectomy (RA), we sought to evaluate the clinical impact of the early application of the RA strategy. Consecutive patients with severe coronary artery calcification were enrolled, who underwent percutaneous coronary intervention (PCI) using RA between January 2010 and October 2019 at 9 tertiary centers. Direct RA was defined as the early application of RA before the balloon was expanded to a size more than or equal to 2.0 mm. The primary endpoint was the composite outcome of technical failure or severe coronary dissection (type D, E, or F) during entire procedure. Of 581 lesions, 360 (62.0%) lesions underwent direct RA. The technical success rate was higher in the direct RA group than in the indirect RA group (97.5% vs. 93.7%, p = 0.021). The primary endpoint was more frequently observed in the indirect RA group than in the direct RA group (24.4% vs. 11.9%, p < 0.001). Multivariate logistic regression analysis revealed that the risk of the primary endpoint was higher in the indirect RA group than in the direct RA group (odds ratio 2.512, 95% CI 1.547–4.078, p < 0.001). Early application of RA may reduce the incidences of in-hospital adverse events and procedure-related complications. |
| format | Article |
| id | doaj-art-a36ac02659d840d7ad0b2999872c9ab3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a36ac02659d840d7ad0b2999872c9ab32025-02-09T12:32:33ZengNature PortfolioScientific Reports2045-23222025-02-0115111110.1038/s41598-025-88695-wClinical impact of direct rotational atherectomy in patients with complex coronary artery lesionsKyusup Lee0Ji-hoon Jung1Woojin Kwon2Dae-Won Kim3Mahn-Won Park4Ik Jun Choi5Jae-Hwan Lee6Yong Hoon Yoon7Jang Hoon Lee8Sang Rok Lee9Pil Hyung Lee10Seung-Whan Lee11Ki Dong Yoo12Kyeong Ho Yun13Hyun-Jong Lee14Sung-Ho Her15Cardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of KoreaKorea Institute of ToxicologyDepartment of Anaesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of MedicineCardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of KoreaCardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of KoreaCardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of KoreaDepartment of Cardiology, Chungnam National University Sejong Hospital, Chungnam National University School of MedicineDepartment of Cardiology, Chungnam National University Sejong Hospital, Chungnam National University School of MedicineDepartment of Internal Medicine, School of Medicine, Kyungpook National University Hospital, Kyungpook National UniversityDepartment of Cardiology, Chonbuk National University HospitalDepartment of Cardiology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Cardiology, Asan Medical Center, University of Ulsan College of MedicineCardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of KoreaDepartment of Cardiovascular Medicine, Regional Cardiocerebrovascular Center, Wonkwang University HospitalDepartment of Internal Medicine, Sejong General HospitalCardiovascular Research Institute for Intractable Disease, College of Medicine, The Catholic University of KoreaAbstract Owing to limited data on the optimal timing of rotational atherectomy (RA), we sought to evaluate the clinical impact of the early application of the RA strategy. Consecutive patients with severe coronary artery calcification were enrolled, who underwent percutaneous coronary intervention (PCI) using RA between January 2010 and October 2019 at 9 tertiary centers. Direct RA was defined as the early application of RA before the balloon was expanded to a size more than or equal to 2.0 mm. The primary endpoint was the composite outcome of technical failure or severe coronary dissection (type D, E, or F) during entire procedure. Of 581 lesions, 360 (62.0%) lesions underwent direct RA. The technical success rate was higher in the direct RA group than in the indirect RA group (97.5% vs. 93.7%, p = 0.021). The primary endpoint was more frequently observed in the indirect RA group than in the direct RA group (24.4% vs. 11.9%, p < 0.001). Multivariate logistic regression analysis revealed that the risk of the primary endpoint was higher in the indirect RA group than in the direct RA group (odds ratio 2.512, 95% CI 1.547–4.078, p < 0.001). Early application of RA may reduce the incidences of in-hospital adverse events and procedure-related complications.https://doi.org/10.1038/s41598-025-88695-wPercutaneous coronary interventionRotational atherectomyComplex coronary lesionsGuideline |
| spellingShingle | Kyusup Lee Ji-hoon Jung Woojin Kwon Dae-Won Kim Mahn-Won Park Ik Jun Choi Jae-Hwan Lee Yong Hoon Yoon Jang Hoon Lee Sang Rok Lee Pil Hyung Lee Seung-Whan Lee Ki Dong Yoo Kyeong Ho Yun Hyun-Jong Lee Sung-Ho Her Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions Scientific Reports Percutaneous coronary intervention Rotational atherectomy Complex coronary lesions Guideline |
| title | Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions |
| title_full | Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions |
| title_fullStr | Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions |
| title_full_unstemmed | Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions |
| title_short | Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions |
| title_sort | clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions |
| topic | Percutaneous coronary intervention Rotational atherectomy Complex coronary lesions Guideline |
| url | https://doi.org/10.1038/s41598-025-88695-w |
| work_keys_str_mv | AT kyusuplee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT jihoonjung clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT woojinkwon clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT daewonkim clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT mahnwonpark clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT ikjunchoi clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT jaehwanlee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT yonghoonyoon clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT janghoonlee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT sangroklee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT pilhyunglee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT seungwhanlee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT kidongyoo clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT kyeonghoyun clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT hyunjonglee clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions AT sunghoher clinicalimpactofdirectrotationalatherectomyinpatientswithcomplexcoronaryarterylesions |