Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation
Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is the most common MRI method in clinical environments for assessment of perfusion-related parameters. In this study, special emphasis was placed on the shape of the tissue residue function under different physiological conditions....
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Heliyon |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025009016 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859417405194240 |
|---|---|
| author | Ronnie Wirestam Arthur Chakwizira Peter Reinstrup |
| author_facet | Ronnie Wirestam Arthur Chakwizira Peter Reinstrup |
| author_sort | Ronnie Wirestam |
| collection | DOAJ |
| description | Dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is the most common MRI method in clinical environments for assessment of perfusion-related parameters. In this study, special emphasis was placed on the shape of the tissue residue function under different physiological conditions. DSC-MRI-based parameters assumed to reflect arterial delay and cerebral oxygen extraction were obtained by deconvolution of tissue and arterial contrast-agent concentration time curves. The established mean transit time (MTT) estimate was supplemented by biophysical modelling for extraction of the oxygen extraction capacity, quantified in terms of an apparent oxygen extraction fraction (AOEF) index. Eight healthy volunteers were examined during normal breathing and spontaneous hyperventilation. Whole-brain MTT and AOEF increased during hyperventilation in all volunteers (average increase 33 % and 30 %, respectively). The arterial delay, reflecting the inverse of arterial flow rate, was also prolonged in all volunteers, and the mean arterial delay was 63 % longer during hyperventilation. The corresponding whole-brain MTT estimates were 3.8 ± 0.7 s during normal breathing and 5.0 ± 1.3 s during hyperventilation (mean ± SD, n = 8). The applied Bézier curve deconvolution algorithm returned tissue residue functions of plausible shapes, i.e., without oscillations and negative values, and some indications that curve shape is relevant for improved assessment of oxygen extraction properties were demonstrated. |
| format | Article |
| id | doaj-art-a4515f9776174076afb95328da860bc3 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-a4515f9776174076afb95328da860bc32025-02-11T04:35:17ZengElsevierHeliyon2405-84402025-02-01114e42521Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilationRonnie Wirestam0Arthur Chakwizira1Peter Reinstrup2Dept. of Medical Radiation Physics, Lund University, Lund, Sweden; Corresponding author. Department of Medical Radiation Physics, Lund University, Skåne University Hospital Lund, SE-22185 Lund, Sweden.Dept. of Medical Radiation Physics, Lund University, Lund, SwedenDept. of Intensive & Perioperative Care, Skåne University Hospital, Lund, SwedenDynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) is the most common MRI method in clinical environments for assessment of perfusion-related parameters. In this study, special emphasis was placed on the shape of the tissue residue function under different physiological conditions. DSC-MRI-based parameters assumed to reflect arterial delay and cerebral oxygen extraction were obtained by deconvolution of tissue and arterial contrast-agent concentration time curves. The established mean transit time (MTT) estimate was supplemented by biophysical modelling for extraction of the oxygen extraction capacity, quantified in terms of an apparent oxygen extraction fraction (AOEF) index. Eight healthy volunteers were examined during normal breathing and spontaneous hyperventilation. Whole-brain MTT and AOEF increased during hyperventilation in all volunteers (average increase 33 % and 30 %, respectively). The arterial delay, reflecting the inverse of arterial flow rate, was also prolonged in all volunteers, and the mean arterial delay was 63 % longer during hyperventilation. The corresponding whole-brain MTT estimates were 3.8 ± 0.7 s during normal breathing and 5.0 ± 1.3 s during hyperventilation (mean ± SD, n = 8). The applied Bézier curve deconvolution algorithm returned tissue residue functions of plausible shapes, i.e., without oscillations and negative values, and some indications that curve shape is relevant for improved assessment of oxygen extraction properties were demonstrated.http://www.sciencedirect.com/science/article/pii/S2405844025009016 |
| spellingShingle | Ronnie Wirestam Arthur Chakwizira Peter Reinstrup Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation Heliyon |
| title | Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation |
| title_full | Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation |
| title_fullStr | Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation |
| title_full_unstemmed | Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation |
| title_short | Evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast MRI: Healthy volunteers examined during normal breathing and spontaneous hyperventilation |
| title_sort | evaluation of parameters extracted from tissue residue functions in dynamic susceptibility contrast mri healthy volunteers examined during normal breathing and spontaneous hyperventilation |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025009016 |
| work_keys_str_mv | AT ronniewirestam evaluationofparametersextractedfromtissueresiduefunctionsindynamicsusceptibilitycontrastmrihealthyvolunteersexaminedduringnormalbreathingandspontaneoushyperventilation AT arthurchakwizira evaluationofparametersextractedfromtissueresiduefunctionsindynamicsusceptibilitycontrastmrihealthyvolunteersexaminedduringnormalbreathingandspontaneoushyperventilation AT peterreinstrup evaluationofparametersextractedfromtissueresiduefunctionsindynamicsusceptibilitycontrastmrihealthyvolunteersexaminedduringnormalbreathingandspontaneoushyperventilation |