Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment
Abstract Background Cardiovascular diseases (CVDs) marked with cardiac morphological or hemodynamical abnormalities are associated with mild cognitive impairment (MCI). The links between cardiac structure and function and MCI are not well understood. We aimed to explore the association between echoc...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-025-04528-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823863292193406976 |
|---|---|
| author | Kai Zhang Xiaoxia Liu Siyu Huang Xinrui Liu Meiqi Zhao Chao Xue Shijun Xia Jianzeng Dong Yu Kong Changsheng Ma |
| author_facet | Kai Zhang Xiaoxia Liu Siyu Huang Xinrui Liu Meiqi Zhao Chao Xue Shijun Xia Jianzeng Dong Yu Kong Changsheng Ma |
| author_sort | Kai Zhang |
| collection | DOAJ |
| description | Abstract Background Cardiovascular diseases (CVDs) marked with cardiac morphological or hemodynamical abnormalities are associated with mild cognitive impairment (MCI). The links between cardiac structure and function and MCI are not well understood. We aimed to explore the association between echocardiographic parameters of cardiac structure and function and MCI in CVD patients. Methods We conducted an age-, gender-, and education level-matched case–control study in general CVD participants with a 1:3 ratio of MCI (Montreal Cognitive Assessment [MoCA] score < 26 and Mini-Mental State Examination [MMSE] score ≥ 24) and cognitively normal participants at a tertiary hospital in Beijing, China. The echocardiographic cardiac parameters and cognitive status were retrieved through the clinical electronic database from May 2021 to August 2023. Principal component analysis (PCA), negative binomial, and conditional multivariate regression were performed. Results A total of 1136 CVD participants (mean age, 61.2 ± 8.3 years) were included in the study, comprising 289 (25.3%) MCI and 847 cognitively normal participants. Compared to cognitively normal participants, MCI participants had a higher prevalence of left ventricular (LV) diastolic dysfunction (54.0% vs. 40.3%; P < 0.001) and greater interventricular septal thickness (IVST) (1.04 ± 0.20 cm vs. 1.00 ± 0.17 cm; P = 0.002). LV diastolic dysfunction (Beta [SE], 0.234 [0.045]; P < 0.001) and IVST (Beta [SE], 0.034 [0.016]; P = 0.036) were negatively correlated with the MoCA score of global cognitive function. LV diastolic dysfunction (OR, 2.03; 95% CI, 1.48–2.79; P < 0.001) and IVST (OR, 1.14; 95% CI, 1.03–1.27; P = 0.014) were positively associated with MCI, independent of diagnosed CVDs and the conventional MCI risk factors. Conclusions General CVD patients with abnormal echocardiographic LV diastolic dysfunction and IVST were associated with cognitive decline, suggesting further cognitive assessment for MCI. Trial registration Retrospectively registered. |
| format | Article |
| id | doaj-art-a4562a48598846c39ab1b0c907a4599f |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-a4562a48598846c39ab1b0c907a4599f2025-02-09T12:11:10ZengBMCBMC Cardiovascular Disorders1471-22612025-02-012511910.1186/s12872-025-04528-8Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairmentKai Zhang0Xiaoxia Liu1Siyu Huang2Xinrui Liu3Meiqi Zhao4Chao Xue5Shijun Xia6Jianzeng Dong7Yu Kong8Changsheng Ma9Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionBeijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders & National Center for Mental Disorders, Beijing Anding Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionEchocardiography Medical Center, Beijing Anzhen Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, National Clinical Research Center for Cardiovascular Diseases, Office of Beijing Cardiovascular Diseases PreventionAbstract Background Cardiovascular diseases (CVDs) marked with cardiac morphological or hemodynamical abnormalities are associated with mild cognitive impairment (MCI). The links between cardiac structure and function and MCI are not well understood. We aimed to explore the association between echocardiographic parameters of cardiac structure and function and MCI in CVD patients. Methods We conducted an age-, gender-, and education level-matched case–control study in general CVD participants with a 1:3 ratio of MCI (Montreal Cognitive Assessment [MoCA] score < 26 and Mini-Mental State Examination [MMSE] score ≥ 24) and cognitively normal participants at a tertiary hospital in Beijing, China. The echocardiographic cardiac parameters and cognitive status were retrieved through the clinical electronic database from May 2021 to August 2023. Principal component analysis (PCA), negative binomial, and conditional multivariate regression were performed. Results A total of 1136 CVD participants (mean age, 61.2 ± 8.3 years) were included in the study, comprising 289 (25.3%) MCI and 847 cognitively normal participants. Compared to cognitively normal participants, MCI participants had a higher prevalence of left ventricular (LV) diastolic dysfunction (54.0% vs. 40.3%; P < 0.001) and greater interventricular septal thickness (IVST) (1.04 ± 0.20 cm vs. 1.00 ± 0.17 cm; P = 0.002). LV diastolic dysfunction (Beta [SE], 0.234 [0.045]; P < 0.001) and IVST (Beta [SE], 0.034 [0.016]; P = 0.036) were negatively correlated with the MoCA score of global cognitive function. LV diastolic dysfunction (OR, 2.03; 95% CI, 1.48–2.79; P < 0.001) and IVST (OR, 1.14; 95% CI, 1.03–1.27; P = 0.014) were positively associated with MCI, independent of diagnosed CVDs and the conventional MCI risk factors. Conclusions General CVD patients with abnormal echocardiographic LV diastolic dysfunction and IVST were associated with cognitive decline, suggesting further cognitive assessment for MCI. Trial registration Retrospectively registered.https://doi.org/10.1186/s12872-025-04528-8EchocardiographyCardiac structure and functionMild cognitive impairment |
| spellingShingle | Kai Zhang Xiaoxia Liu Siyu Huang Xinrui Liu Meiqi Zhao Chao Xue Shijun Xia Jianzeng Dong Yu Kong Changsheng Ma Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment BMC Cardiovascular Disorders Echocardiography Cardiac structure and function Mild cognitive impairment |
| title | Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment |
| title_full | Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment |
| title_fullStr | Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment |
| title_full_unstemmed | Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment |
| title_short | Association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment |
| title_sort | association between echocardiographic parameters of cardiac structure and function and mild cognitive impairment |
| topic | Echocardiography Cardiac structure and function Mild cognitive impairment |
| url | https://doi.org/10.1186/s12872-025-04528-8 |
| work_keys_str_mv | AT kaizhang associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT xiaoxialiu associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT siyuhuang associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT xinruiliu associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT meiqizhao associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT chaoxue associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT shijunxia associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT jianzengdong associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT yukong associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment AT changshengma associationbetweenechocardiographicparametersofcardiacstructureandfunctionandmildcognitiveimpairment |