Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration
Abstract Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract i...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-02-01
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| Series: | Bone Research |
| Online Access: | https://doi.org/10.1038/s41413-024-00386-w |
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| author | Peisheng Liu Hao Guo Xiaoyao Huang Anqi Liu Ting Zhu Chenxi Zheng Fei Fu Kaichao Zhang Shijie Li Xinyan Luo Jiongyi Tian Yan Jin Kun Xuan Bingdong Sui |
| author_facet | Peisheng Liu Hao Guo Xiaoyao Huang Anqi Liu Ting Zhu Chenxi Zheng Fei Fu Kaichao Zhang Shijie Li Xinyan Luo Jiongyi Tian Yan Jin Kun Xuan Bingdong Sui |
| author_sort | Peisheng Liu |
| collection | DOAJ |
| description | Abstract Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell (MSC) function and regeneration. Interestingly, replenishment of cell aggregates-derived extracellular vesicles (CA-EVs) rescues Golgi dysfunction and empowers senescent MSCs through the Golgi regulatory protein Syntaxin 5. Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. Collectively, our findings provide insights into Golgi regulation in stem cell senescence and bone aging, which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration. |
| format | Article |
| id | doaj-art-a48d9296cb8640b2abe21206731b8b20 |
| institution | Kabale University |
| issn | 2095-6231 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Bone Research |
| spelling | doaj-art-a48d9296cb8640b2abe21206731b8b202025-02-09T12:16:58ZengNature Publishing GroupBone Research2095-62312025-02-0113111410.1038/s41413-024-00386-wGolgi-restored vesicular replenishment retards bone aging and empowers aging bone regenerationPeisheng Liu0Hao Guo1Xiaoyao Huang2Anqi Liu3Ting Zhu4Chenxi Zheng5Fei Fu6Kaichao Zhang7Shijie Li8Xinyan Luo9Jiongyi Tian10Yan Jin11Kun Xuan12Bingdong Sui13State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi International Joint Research Center for Oral Disease, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical UniversityAbstract Healthy aging is a common goal for humanity and society, and one key to achieving it is the rejuvenation of senescent resident stem cells and empowerment of aging organ regeneration. However, the mechanistic understandings of stem cell senescence and the potential strategies to counteract it remain elusive. Here, we reveal that the aging bone microenvironment impairs the Golgi apparatus thus diminishing mesenchymal stem cell (MSC) function and regeneration. Interestingly, replenishment of cell aggregates-derived extracellular vesicles (CA-EVs) rescues Golgi dysfunction and empowers senescent MSCs through the Golgi regulatory protein Syntaxin 5. Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. Collectively, our findings provide insights into Golgi regulation in stem cell senescence and bone aging, which further highlight CA-EVs as a potential rejuvenative approach for aging bone regeneration.https://doi.org/10.1038/s41413-024-00386-w |
| spellingShingle | Peisheng Liu Hao Guo Xiaoyao Huang Anqi Liu Ting Zhu Chenxi Zheng Fei Fu Kaichao Zhang Shijie Li Xinyan Luo Jiongyi Tian Yan Jin Kun Xuan Bingdong Sui Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration Bone Research |
| title | Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration |
| title_full | Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration |
| title_fullStr | Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration |
| title_full_unstemmed | Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration |
| title_short | Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration |
| title_sort | golgi restored vesicular replenishment retards bone aging and empowers aging bone regeneration |
| url | https://doi.org/10.1038/s41413-024-00386-w |
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