Atezolizumab neutralizing assay development: a novel way of evaluating assay cutpoint after sample pretreatment

Atezolizumab neutralizing assay development: a novel way of evaluating assay cutpoint after sample pretreatment

Abstract Atezolizumab, a biotherapeutic monoclonal antibody directed against PD-L1, has been shown to be efficacious in multiple oncology indications. In clinical trials, a subset of patients developed anti-atezolizumab antibodies, necessitating the development of a neutralizing antibody (NAb) assay...

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Bibliographic Details
Main Authors:	Rachel Melendez, Jane Ruppel, Cecilia Leddy, Jenny Yang, Ann Brady, Yenny Webb-Vargas, Jochen Brumm, Lynn Kamen, Yuan Song
Format:	Article
Language:	English
Published:	SpringerOpen 2025-02-01
Series:	AAPS Open
Online Access:	https://doi.org/10.1186/s41120-024-00105-z
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