Irritable Bowel Syndrome in Terms of Changes in the Microbiota
Aim: to review available data confirming the pathogenetic role of the intestinal microbiota in the formation of irritable bowel syndrome (IBS).Key findings. Changes in the intestinal biotope cause the development of visceral hypersensitivity and impaired intestinal motor activity, as well as neuroim...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2019-03-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/330 |
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| _version_ | 1823860152257740800 |
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| author | Vladimir T. Ivashkin Oxana Yu. Zolnikova |
| author_facet | Vladimir T. Ivashkin Oxana Yu. Zolnikova |
| author_sort | Vladimir T. Ivashkin |
| collection | DOAJ |
| description | Aim: to review available data confirming the pathogenetic role of the intestinal microbiota in the formation of irritable bowel syndrome (IBS).Key findings. Changes in the intestinal biotope cause the development of visceral hypersensitivity and impaired intestinal motor activity, as well as neuroimmune transmission. This article discusses the main aspects of the biological properties of probiotic bacteria in terms of their action within the “brain — intestine — microbiota” chain. The results of experimental and clinical studies elucidating the mechanisms of action of probiotic cultures have been generalized. The understanding of these mechanisms allows practitioners to make informed decisions in prescribing probiotics to IBS patients. Key concepts concerning fecal microbiota transplantation, as well as the prospects and difficulties of implementing this approach are considered.Conclusions. The term “microbiota — intestine — brain” clearly demonstrates the correlation between the main functional components of IBS. Meta-analyses and systematic reviews confirm the efficacy of probiotics in IBS. However, further research into probiotic therapy options is needed to identify specific bacterial strains with proven clinical efficacy. The fecal microbiota transplantation method also requires further research, since many issues associated with this approach remain unclear. |
| format | Article |
| id | doaj-art-a6f54bf02bda4615b40f0f43a2354d52 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2019-03-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-a6f54bf02bda4615b40f0f43a2354d522025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732019-03-01291687610.22416/1382-4376-2019-29-1-84-92288Irritable Bowel Syndrome in Terms of Changes in the MicrobiotaVladimir T. Ivashkin0Oxana Yu. Zolnikova1I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim: to review available data confirming the pathogenetic role of the intestinal microbiota in the formation of irritable bowel syndrome (IBS).Key findings. Changes in the intestinal biotope cause the development of visceral hypersensitivity and impaired intestinal motor activity, as well as neuroimmune transmission. This article discusses the main aspects of the biological properties of probiotic bacteria in terms of their action within the “brain — intestine — microbiota” chain. The results of experimental and clinical studies elucidating the mechanisms of action of probiotic cultures have been generalized. The understanding of these mechanisms allows practitioners to make informed decisions in prescribing probiotics to IBS patients. Key concepts concerning fecal microbiota transplantation, as well as the prospects and difficulties of implementing this approach are considered.Conclusions. The term “microbiota — intestine — brain” clearly demonstrates the correlation between the main functional components of IBS. Meta-analyses and systematic reviews confirm the efficacy of probiotics in IBS. However, further research into probiotic therapy options is needed to identify specific bacterial strains with proven clinical efficacy. The fecal microbiota transplantation method also requires further research, since many issues associated with this approach remain unclear.https://www.gastro-j.ru/jour/article/view/330irritable bowel syndromelactobacteriabifidobacteriaprobioticsintestinal microbiota |
| spellingShingle | Vladimir T. Ivashkin Oxana Yu. Zolnikova Irritable Bowel Syndrome in Terms of Changes in the Microbiota Российский журнал гастроэнтерологии, гепатологии, колопроктологии irritable bowel syndrome lactobacteria bifidobacteria probiotics intestinal microbiota |
| title | Irritable Bowel Syndrome in Terms of Changes in the Microbiota |
| title_full | Irritable Bowel Syndrome in Terms of Changes in the Microbiota |
| title_fullStr | Irritable Bowel Syndrome in Terms of Changes in the Microbiota |
| title_full_unstemmed | Irritable Bowel Syndrome in Terms of Changes in the Microbiota |
| title_short | Irritable Bowel Syndrome in Terms of Changes in the Microbiota |
| title_sort | irritable bowel syndrome in terms of changes in the microbiota |
| topic | irritable bowel syndrome lactobacteria bifidobacteria probiotics intestinal microbiota |
| url | https://www.gastro-j.ru/jour/article/view/330 |
| work_keys_str_mv | AT vladimirtivashkin irritablebowelsyndromeintermsofchangesinthemicrobiota AT oxanayuzolnikova irritablebowelsyndromeintermsofchangesinthemicrobiota |