Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex
Summary: Positive emotions determine individual well-being and sustainable social relationships. Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female volunteers. We identified brain regions engaged in...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225001695 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861202974932992 |
|---|---|
| author | Dmitriy D. Bezmaternykh Mikhail Ye. Melnikov Evgeny D. Petrovskiy Ksenia G. Mazhirina Andrey A. Savelov Mark B. Shtark Patrik Vuilleumier Yury Koush |
| author_facet | Dmitriy D. Bezmaternykh Mikhail Ye. Melnikov Evgeny D. Petrovskiy Ksenia G. Mazhirina Andrey A. Savelov Mark B. Shtark Patrik Vuilleumier Yury Koush |
| author_sort | Dmitriy D. Bezmaternykh |
| collection | DOAJ |
| description | Summary: Positive emotions determine individual well-being and sustainable social relationships. Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female volunteers. We identified brain regions engaged in upregulation of positive social emotions and applied a parametric empirical Bayes approach to isolate modulated network connectivity patterns and assess how these effects relate to individual measures of social perception. Our findings indicate that upregulation of positive social emotions shapes the functional interplay between affective valuation and cognitive control functions. We revealed a selective increase of bilateral posterior ventrolateral prefrontal cortex (vlPFC) activity and attenuation of activity in right anterior vlPFC under control influences from more superior prefrontal regions. We also found that individual perception of sociality modulates connectivity between affective and social networks. This study expands our understanding of neural circuits required to balance positive emotions in social situations and their rehabilitative potential. |
| format | Article |
| id | doaj-art-a73cb3645651420da472e3683524cd14 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-a73cb3645651420da472e3683524cd142025-02-10T04:34:44ZengElsevieriScience2589-00422025-02-01282111909Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortexDmitriy D. Bezmaternykh0Mikhail Ye. Melnikov1Evgeny D. Petrovskiy2Ksenia G. Mazhirina3Andrey A. Savelov4Mark B. Shtark5Patrik Vuilleumier6Yury Koush7Institute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia; Department of Biophysics, Biomedicine, and Neuroscience, Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, KazakhstanInternational Tomography Center SB RAS, Novosibirsk, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, RussiaInternational Tomography Center SB RAS, Novosibirsk, RussiaInstitute of Molecular Biology and Biophysics, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, RussiaDepartment of Neuroscience, Medical School, University of Geneva, Geneva, Switzerland; Swiss Center of Affective Sciences, University of Geneva, Campus Biotech, Geneva, SwitzerlandVladimir Zelman Center for Neurobiology and Brain Rehabilitation, Skolkovo Institute of Technology, Moscow, Russia; Department of Biomedical Engineering, Yale University, New Haven, CT, USA; Corresponding authorSummary: Positive emotions determine individual well-being and sustainable social relationships. Here, we examined the neural processes mediating upregulation of positive social emotions using functional magnetic resonance imaging in healthy female volunteers. We identified brain regions engaged in upregulation of positive social emotions and applied a parametric empirical Bayes approach to isolate modulated network connectivity patterns and assess how these effects relate to individual measures of social perception. Our findings indicate that upregulation of positive social emotions shapes the functional interplay between affective valuation and cognitive control functions. We revealed a selective increase of bilateral posterior ventrolateral prefrontal cortex (vlPFC) activity and attenuation of activity in right anterior vlPFC under control influences from more superior prefrontal regions. We also found that individual perception of sociality modulates connectivity between affective and social networks. This study expands our understanding of neural circuits required to balance positive emotions in social situations and their rehabilitative potential.http://www.sciencedirect.com/science/article/pii/S2589004225001695NeuroscienceBehavioral neuroscience |
| spellingShingle | Dmitriy D. Bezmaternykh Mikhail Ye. Melnikov Evgeny D. Petrovskiy Ksenia G. Mazhirina Andrey A. Savelov Mark B. Shtark Patrik Vuilleumier Yury Koush Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex iScience Neuroscience Behavioral neuroscience |
| title | Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex |
| title_full | Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex |
| title_fullStr | Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex |
| title_full_unstemmed | Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex |
| title_short | Attenuation processes in positive social emotion upregulation: Disentangling functional role of ventrolateral prefrontal cortex |
| title_sort | attenuation processes in positive social emotion upregulation disentangling functional role of ventrolateral prefrontal cortex |
| topic | Neuroscience Behavioral neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225001695 |
| work_keys_str_mv | AT dmitriydbezmaternykh attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT mikhailyemelnikov attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT evgenydpetrovskiy attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT kseniagmazhirina attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT andreyasavelov attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT markbshtark attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT patrikvuilleumier attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex AT yurykoush attenuationprocessesinpositivesocialemotionupregulationdisentanglingfunctionalroleofventrolateralprefrontalcortex |