Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts

Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts

Summary: Differentiation into plasma cells (PCs) enables secretion of ∼10,000 immunoglobulin molecules per second. This extraordinary capacity requires the upregulation of PC transcriptional determinants that specify PC fate, increase immunoglobulin mRNA synthesis, coordinate alternative 3′ end proc...

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Bibliographic Details
Main Authors: Evelyn P. Sievert, Marissa C. Franke, Kayla B. Thomas, Yoseop Yoon, Yongsheng Shi, Roger Sciammas
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725000543
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