Natural products against resistant bacterial infections: A systematic literature review
Background: Antibiotic resistance is a global threat and recently, World Health Organization (WHO) has declared antimicrobial resistance as one of the top 10 global public health threats. The existing antibiotics are becoming ineffective which results in serious complications and even death of the p...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | The Microbe |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950194625000159 |
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| author | Harshit Kaushik Ruchika Sharma Anoop Kumar |
| author_facet | Harshit Kaushik Ruchika Sharma Anoop Kumar |
| author_sort | Harshit Kaushik |
| collection | DOAJ |
| description | Background: Antibiotic resistance is a global threat and recently, World Health Organization (WHO) has declared antimicrobial resistance as one of the top 10 global public health threats. The existing antibiotics are becoming ineffective which results in serious complications and even death of the patients. Natural products have tremendous potential against resistant infections due to their multimodal mechanism of action. However, the exact potential is unclear so far. Aim: Thus, we have conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to determine the role of natural products. Methodology: The relevant studies were searched in PubMed and clinical trial websites till 18th February 2022. Results: Out of 11,869 studies, 361 studies were selected for qualitative analysis as per the defined inclusion and exclusion criteria. The results have indicated the antibacterial potential of natural products in concentration/dose/dosage manner under in-vitro, in-vivo, and clinical conditions via different mechanisms of action Conclusion: Overall, available evidence has indicated the potential of natural products against various types of resistant bacterial strains under in-vitro, in-vivo, and clinical conditions. |
| format | Article |
| id | doaj-art-abe5e9b7ddfb44beab8dcd66be1b2e06 |
| institution | Kabale University |
| issn | 2950-1946 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Microbe |
| spelling | doaj-art-abe5e9b7ddfb44beab8dcd66be1b2e062025-02-12T05:33:17ZengElsevierThe Microbe2950-19462025-03-016100247Natural products against resistant bacterial infections: A systematic literature reviewHarshit Kaushik0Ruchika Sharma1Anoop Kumar2Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Lucknow 226002, IndiaCentre for Precision Medicine and Pharmacy (CPMP), Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi 110017, IndiaDepartment of Pharmacology, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi 110017, India; Corresponding author.Background: Antibiotic resistance is a global threat and recently, World Health Organization (WHO) has declared antimicrobial resistance as one of the top 10 global public health threats. The existing antibiotics are becoming ineffective which results in serious complications and even death of the patients. Natural products have tremendous potential against resistant infections due to their multimodal mechanism of action. However, the exact potential is unclear so far. Aim: Thus, we have conducted a systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to determine the role of natural products. Methodology: The relevant studies were searched in PubMed and clinical trial websites till 18th February 2022. Results: Out of 11,869 studies, 361 studies were selected for qualitative analysis as per the defined inclusion and exclusion criteria. The results have indicated the antibacterial potential of natural products in concentration/dose/dosage manner under in-vitro, in-vivo, and clinical conditions via different mechanisms of action Conclusion: Overall, available evidence has indicated the potential of natural products against various types of resistant bacterial strains under in-vitro, in-vivo, and clinical conditions.http://www.sciencedirect.com/science/article/pii/S2950194625000159Natural productsMethicillin-Resistant Staphylococcus aureus (MRSA)Vancomycin-Resistant Enterococcus (VRE)Multi-Drug-Resistance (MDR)Carbapenem-Resistant Enterobacterales (CRE) |
| spellingShingle | Harshit Kaushik Ruchika Sharma Anoop Kumar Natural products against resistant bacterial infections: A systematic literature review The Microbe Natural products Methicillin-Resistant Staphylococcus aureus (MRSA) Vancomycin-Resistant Enterococcus (VRE) Multi-Drug-Resistance (MDR) Carbapenem-Resistant Enterobacterales (CRE) |
| title | Natural products against resistant bacterial infections: A systematic literature review |
| title_full | Natural products against resistant bacterial infections: A systematic literature review |
| title_fullStr | Natural products against resistant bacterial infections: A systematic literature review |
| title_full_unstemmed | Natural products against resistant bacterial infections: A systematic literature review |
| title_short | Natural products against resistant bacterial infections: A systematic literature review |
| title_sort | natural products against resistant bacterial infections a systematic literature review |
| topic | Natural products Methicillin-Resistant Staphylococcus aureus (MRSA) Vancomycin-Resistant Enterococcus (VRE) Multi-Drug-Resistance (MDR) Carbapenem-Resistant Enterobacterales (CRE) |
| url | http://www.sciencedirect.com/science/article/pii/S2950194625000159 |
| work_keys_str_mv | AT harshitkaushik naturalproductsagainstresistantbacterialinfectionsasystematicliteraturereview AT ruchikasharma naturalproductsagainstresistantbacterialinfectionsasystematicliteraturereview AT anoopkumar naturalproductsagainstresistantbacterialinfectionsasystematicliteraturereview |