Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer
Cervical cancer (CaCx) is the fourth most prevalent cancer in women contributing to 341,831 annual deaths globally in 2020. Owing to its high mortality rate, the identification of novel inhibitors preventing CaCx progression is of utmost importance. Recent studies have emphasized the use of phytoche...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Open Exploration
2024-09-01
|
| Series: | Exploration of Drug Science |
| Subjects: | |
| Online Access: | https://www.explorationpub.com/uploads/Article/A100863/100863.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825199595687247872 |
|---|---|
| author | Tanya Tripathi Apoorva Chaudhary Divya Janjua Udit Joshi Nikita Aggarwal Chetkar Chandra Keshavam Alok Chandra Bharti |
| author_facet | Tanya Tripathi Apoorva Chaudhary Divya Janjua Udit Joshi Nikita Aggarwal Chetkar Chandra Keshavam Alok Chandra Bharti |
| author_sort | Tanya Tripathi |
| collection | DOAJ |
| description | Cervical cancer (CaCx) is the fourth most prevalent cancer in women contributing to 341,831 annual deaths globally in 2020. Owing to its high mortality rate, the identification of novel inhibitors preventing CaCx progression is of utmost importance. Recent studies have emphasized the use of phytochemicals for cancer prevention due to their low toxicity. Psoralidin, a bioactive compound extracted from the seeds of the medicinal plant Psoralea corylifolia, showcases the potential for promoting health benefits. A range of studies showing anti-inflammatory, anti-oxidant, estrogenic, neuroprotective, anti-diabetic, anti-depressant, antimicrobial, and anti-tumor activities substantiate its promising biological effects. The anti-tumor potential of psoralidin has been well-documented. Its capacity to effectively target cancer stem cells (CSCs) in general adds to its therapeutic potential. Psoralidin carries out its anti-cancer activity by inducing oxidative stress, autophagy, and apoptosis. This unique characteristic suggests its potential to be used as an adjunct molecule in combination with existing treatment to enhance the efficacy of chemo/radiotherapy for treating CaCx. However, low bioavailability and intestinal efflux limit the use of psoralidin in clinical applications. Therefore, further investigation is needed in area of drug delivery and mechanism of action to fully harness the beneficial effects of psoralidin. The present study examines the current understanding of the molecular properties of this coumestan, as well as its various molecular targets with a particular emphasis on its anti-cancer activity. The study will help in designing effective and novel therapeutic interventions for targeting signaling pathways and other regulators involved in mediating CaCx progression, which will eventually help in effective management of CaCx. |
| format | Article |
| id | doaj-art-ac493e0e31d74adc833994fcfd490351 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-ac493e0e31d74adc833994fcfd4903512025-02-08T03:29:23ZengOpen ExplorationExploration of Drug Science2836-76772024-09-012558361310.37349/eds.2024.00063Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancerTanya Tripathi0Apoorva Chaudhary1Divya Janjua2Udit Joshi3Nikita Aggarwal4Chetkar Chandra Keshavam5Alok Chandra Bharti6https://orcid.org/0000-0002-5996-2832Molecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaMolecular Oncology Laboratory, Department of Zoology, University of Delhi (North Campus), Delhi 110007, IndiaCervical cancer (CaCx) is the fourth most prevalent cancer in women contributing to 341,831 annual deaths globally in 2020. Owing to its high mortality rate, the identification of novel inhibitors preventing CaCx progression is of utmost importance. Recent studies have emphasized the use of phytochemicals for cancer prevention due to their low toxicity. Psoralidin, a bioactive compound extracted from the seeds of the medicinal plant Psoralea corylifolia, showcases the potential for promoting health benefits. A range of studies showing anti-inflammatory, anti-oxidant, estrogenic, neuroprotective, anti-diabetic, anti-depressant, antimicrobial, and anti-tumor activities substantiate its promising biological effects. The anti-tumor potential of psoralidin has been well-documented. Its capacity to effectively target cancer stem cells (CSCs) in general adds to its therapeutic potential. Psoralidin carries out its anti-cancer activity by inducing oxidative stress, autophagy, and apoptosis. This unique characteristic suggests its potential to be used as an adjunct molecule in combination with existing treatment to enhance the efficacy of chemo/radiotherapy for treating CaCx. However, low bioavailability and intestinal efflux limit the use of psoralidin in clinical applications. Therefore, further investigation is needed in area of drug delivery and mechanism of action to fully harness the beneficial effects of psoralidin. The present study examines the current understanding of the molecular properties of this coumestan, as well as its various molecular targets with a particular emphasis on its anti-cancer activity. The study will help in designing effective and novel therapeutic interventions for targeting signaling pathways and other regulators involved in mediating CaCx progression, which will eventually help in effective management of CaCx.https://www.explorationpub.com/uploads/Article/A100863/100863.pdfcervical cancerpsoralidinreactive oxygen speciesanti-inflammatoryosteoporosisanti-tumor |
| spellingShingle | Tanya Tripathi Apoorva Chaudhary Divya Janjua Udit Joshi Nikita Aggarwal Chetkar Chandra Keshavam Alok Chandra Bharti Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer Exploration of Drug Science cervical cancer psoralidin reactive oxygen species anti-inflammatory osteoporosis anti-tumor |
| title | Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer |
| title_full | Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer |
| title_fullStr | Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer |
| title_full_unstemmed | Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer |
| title_short | Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer |
| title_sort | psoralidin emerging biological activities of therapeutic benefits and its potential utility in cervical cancer |
| topic | cervical cancer psoralidin reactive oxygen species anti-inflammatory osteoporosis anti-tumor |
| url | https://www.explorationpub.com/uploads/Article/A100863/100863.pdf |
| work_keys_str_mv | AT tanyatripathi psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer AT apoorvachaudhary psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer AT divyajanjua psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer AT uditjoshi psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer AT nikitaaggarwal psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer AT chetkarchandrakeshavam psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer AT alokchandrabharti psoralidinemergingbiologicalactivitiesoftherapeuticbenefitsanditspotentialutilityincervicalcancer |