Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses
PurposeEjaculatory abstinence (EA) duration is recognized to impact semen parameters. This study aims to evaluate the effects of varying EA durations on semen quality parameters, distinguishing between normospermic and sub-fertile men, and to provide insights into tailored abstinence recommendations...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2025.1529262/full |
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| author | Giorgio Ivan Russo Maria Giovanna Asmundo Andrea Cocci Ali Saber Abdelhameed Annalisa Liprino Filippo Giacone Debora Lombardo Antonino Guglielmino Sandrine Chamayou |
| author_facet | Giorgio Ivan Russo Maria Giovanna Asmundo Andrea Cocci Ali Saber Abdelhameed Annalisa Liprino Filippo Giacone Debora Lombardo Antonino Guglielmino Sandrine Chamayou |
| author_sort | Giorgio Ivan Russo |
| collection | DOAJ |
| description | PurposeEjaculatory abstinence (EA) duration is recognized to impact semen parameters. This study aims to evaluate the effects of varying EA durations on semen quality parameters, distinguishing between normospermic and sub-fertile men, and to provide insights into tailored abstinence recommendations for improved fertility outcomes.MethodsWe retrospectively analyzed 23,527 semen samples from men undergoing infertility evaluation from 2013 to 2024. Semen parameters, including sperm concentration, motility, and morphology, were assessed post-abstinence (2–7 days) according to WHO guidelines. Group differences were analyzed, focusing on sperm parameters across abstinence periods in normospermic versus patients with sperm abnormalities.ResultsIn normospermic patients we found a trend increase from day 1 to day 7 of abstinence time regarding total sperm count (million) (92.4 vs. 191.1; p<0.01), sperm concentration (million/ml) (44.5 vs. 72.0; p<0.01) and morphology (6 vs. 12.5; p= 0.03) but not regarding motility (A+B) (50.0% vs. 48.0%; p=0.43). Conversely, in the population of patients with sperm abnormality, we found a significant trend increase from day 1 to day 7 of TSC (16.38 vs. 56.0; p<0.01), sperm concentration (million/ml) (8.0 vs. 18.0; p<0.01) and morphology (3.0 vs. 5.0; p<0.01). Interestingly, we found a significant trend decrease of motility (A+B) (28.0% vs. 21.0%; p<0.01) and pH (8.1 vs. 7.9; p<0.01) In patients affected by asthenospermia, motility (A+B) dropped significantly from day 1 to day 7 (11.8% vs. 6.1%; p<0.01) and also in patients with teratospermia morphology dropped significantly (2.13% vs. 1.26%; p<0.01).ConclusionThe findings support the use of tailored abstinence guidelines to optimize semen quality based on patient-specific semen profiles, with normospermic men benefiting from longer abstinence durations to increase concentrations, while patients with motility or morphology impairments, may benefit from shorter abstinence periods to mitigate sperm quality declines. |
| format | Article |
| id | doaj-art-ae88b07f7228494ab6c06313bf564bdf |
| institution | Kabale University |
| issn | 1664-2392 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj-art-ae88b07f7228494ab6c06313bf564bdf2025-02-10T05:16:22ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922025-02-011610.3389/fendo.2025.15292621529262Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analysesGiorgio Ivan Russo0Maria Giovanna Asmundo1Andrea Cocci2Ali Saber Abdelhameed3Annalisa Liprino4Filippo Giacone5Debora Lombardo6Antonino Guglielmino7Sandrine Chamayou8Urology Section, University of Catania, Catania, ItalyUrology Section, University of Catania, Catania, ItalyUrology Section, University of Florence, Florence, ItalyDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaUnità di Medicina della Riproduzione, Centro HERA, Catania, ItalyUnità di Medicina della Riproduzione, Centro HERA, Catania, ItalyUnità di Medicina della Riproduzione, Centro HERA, Catania, ItalyUnità di Medicina della Riproduzione, Centro HERA, Catania, ItalyUnità di Medicina della Riproduzione, Centro HERA, Catania, ItalyPurposeEjaculatory abstinence (EA) duration is recognized to impact semen parameters. This study aims to evaluate the effects of varying EA durations on semen quality parameters, distinguishing between normospermic and sub-fertile men, and to provide insights into tailored abstinence recommendations for improved fertility outcomes.MethodsWe retrospectively analyzed 23,527 semen samples from men undergoing infertility evaluation from 2013 to 2024. Semen parameters, including sperm concentration, motility, and morphology, were assessed post-abstinence (2–7 days) according to WHO guidelines. Group differences were analyzed, focusing on sperm parameters across abstinence periods in normospermic versus patients with sperm abnormalities.ResultsIn normospermic patients we found a trend increase from day 1 to day 7 of abstinence time regarding total sperm count (million) (92.4 vs. 191.1; p<0.01), sperm concentration (million/ml) (44.5 vs. 72.0; p<0.01) and morphology (6 vs. 12.5; p= 0.03) but not regarding motility (A+B) (50.0% vs. 48.0%; p=0.43). Conversely, in the population of patients with sperm abnormality, we found a significant trend increase from day 1 to day 7 of TSC (16.38 vs. 56.0; p<0.01), sperm concentration (million/ml) (8.0 vs. 18.0; p<0.01) and morphology (3.0 vs. 5.0; p<0.01). Interestingly, we found a significant trend decrease of motility (A+B) (28.0% vs. 21.0%; p<0.01) and pH (8.1 vs. 7.9; p<0.01) In patients affected by asthenospermia, motility (A+B) dropped significantly from day 1 to day 7 (11.8% vs. 6.1%; p<0.01) and also in patients with teratospermia morphology dropped significantly (2.13% vs. 1.26%; p<0.01).ConclusionThe findings support the use of tailored abstinence guidelines to optimize semen quality based on patient-specific semen profiles, with normospermic men benefiting from longer abstinence durations to increase concentrations, while patients with motility or morphology impairments, may benefit from shorter abstinence periods to mitigate sperm quality declines.https://www.frontiersin.org/articles/10.3389/fendo.2025.1529262/fullsperminfertilityagemalesperm analysis |
| spellingShingle | Giorgio Ivan Russo Maria Giovanna Asmundo Andrea Cocci Ali Saber Abdelhameed Annalisa Liprino Filippo Giacone Debora Lombardo Antonino Guglielmino Sandrine Chamayou Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses Frontiers in Endocrinology sperm infertility age male sperm analysis |
| title | Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses |
| title_full | Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses |
| title_fullStr | Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses |
| title_full_unstemmed | Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses |
| title_short | Ejaculatory abstinence duration impacts semen parameters: Insights from a retrospective analysis in male infertility on 23,527 analyses |
| title_sort | ejaculatory abstinence duration impacts semen parameters insights from a retrospective analysis in male infertility on 23 527 analyses |
| topic | sperm infertility age male sperm analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2025.1529262/full |
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