XGBoost-enhanced ensemble model using discriminative hybrid features for the prediction of sumoylation sites

XGBoost-enhanced ensemble model using discriminative hybrid features for the prediction of sumoylation sites

Abstract Posttranslational modifications (PTMs) are essential for regulating protein localization and stability, significantly affecting gene expression, biological functions, and genome replication. Among these, sumoylation a PTM that attaches a chemical group to protein sequences—plays a critical...

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Bibliographic Details
Main Authors: Salman Khan, Sumaiya Noor, Tahir Javed, Afshan Naseem, Fahad Aslam, Salman A. AlQahtani, Nijad Ahmad
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BioData Mining
Subjects:
Pseudo position-specific score matrix
Sumoylation
Post-translation modification
XGBoost
SHAP
Online Access:https://doi.org/10.1186/s13040-024-00415-8
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https://doi.org/10.1186/s13040-024-00415-8

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