Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts

Cell autonomous TLR4 signaling modulates TGF-β induced activation of human cardiac fibroblasts

Fibrosis is one of the major outcomes following injury in the heart. Immune response in the injury niche modulates fibrosis, yet little is known about how cell-autonomous immune signaling in adult cardiac fibroblasts regulates fibrosis. Using FACS, single-cell sequencing of cardiac fibroblasts from...

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Bibliographic Details
Main Authors: Gayathri Vijayakumar, Anisha Latha, Aiswaria P. Anil, Yogini Surve, Aiswarya R, Bipin G. Nair, Indulekha CL. Pillai
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025008321
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