Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review
Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis is confirmed through histopathologic examination after curettage, and treatment ty...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
|
| Series: | Case Reports in Women's Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214911225000141 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206895709782016 |
|---|---|
| author | Rayan R. Salahaldin Mais E. Abubaker Ghada M. Abdalqader Anas R. Tuqan Basel A. Zaben Iba Barghouthi |
| author_facet | Rayan R. Salahaldin Mais E. Abubaker Ghada M. Abdalqader Anas R. Tuqan Basel A. Zaben Iba Barghouthi |
| author_sort | Rayan R. Salahaldin |
| collection | DOAJ |
| description | Choriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis is confirmed through histopathologic examination after curettage, and treatment typically involves stage-dependent chemotherapy. This case report concerns a 25-year-old woman with heavy postpartum bleeding, later diagnosed with choriocarcinoma. Despite initial single-agent chemotherapy, disease progression led to uterine perforation and hemoperitoneum, requiring emergency surgery. Following recovery, multi-agent chemotherapy resolved her symptoms. Choriocarcinoma's rarity and varied presentation make diagnosis challenging, with lung metastases common. Levels of b-hCG indicate treatment response, and prompt management combining chemotherapy, monitoring, and surgery is crucial for positive outcomes. |
| format | Article |
| id | doaj-art-afecdd73727e4cafbb2edc35e6ecac11 |
| institution | Kabale University |
| issn | 2214-9112 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Case Reports in Women's Health |
| spelling | doaj-art-afecdd73727e4cafbb2edc35e6ecac112025-02-07T04:47:40ZengElsevierCase Reports in Women's Health2214-91122025-03-0145e00693Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature reviewRayan R. Salahaldin0Mais E. Abubaker1Ghada M. Abdalqader2Anas R. Tuqan3Basel A. Zaben4Iba Barghouthi5Corresponding author at: Al-Quds University-School of Medicine, Jerusalem, East Jerusalem, Palestine.; Al Quds University Faculty of Medicine, Jerusalem, PalestineAl Quds University Faculty of Medicine, Jerusalem, PalestineAl Quds University Faculty of Medicine, Jerusalem, PalestineAl Quds University Faculty of Medicine, Jerusalem, PalestineAl Quds University Faculty of Medicine, Jerusalem, PalestineAl Quds University Faculty of Medicine, Jerusalem, PalestineChoriocarcinoma is a rare, aggressive gestational trophoblastic disorder with metastatic potential, often presenting with abnormal bleeding and increasing levels of beta-human chorionic gonadotropin (b-hCG). Diagnosis is confirmed through histopathologic examination after curettage, and treatment typically involves stage-dependent chemotherapy. This case report concerns a 25-year-old woman with heavy postpartum bleeding, later diagnosed with choriocarcinoma. Despite initial single-agent chemotherapy, disease progression led to uterine perforation and hemoperitoneum, requiring emergency surgery. Following recovery, multi-agent chemotherapy resolved her symptoms. Choriocarcinoma's rarity and varied presentation make diagnosis challenging, with lung metastases common. Levels of b-hCG indicate treatment response, and prompt management combining chemotherapy, monitoring, and surgery is crucial for positive outcomes.http://www.sciencedirect.com/science/article/pii/S2214911225000141ChoriocarcinomaGestational trophoblastic tumorPostpartum bleedingUterine perforationCase report |
| spellingShingle | Rayan R. Salahaldin Mais E. Abubaker Ghada M. Abdalqader Anas R. Tuqan Basel A. Zaben Iba Barghouthi Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review Case Reports in Women's Health Choriocarcinoma Gestational trophoblastic tumor Postpartum bleeding Uterine perforation Case report |
| title | Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review |
| title_full | Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review |
| title_fullStr | Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review |
| title_full_unstemmed | Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review |
| title_short | Postpartum choriocarcinoma complicated by uterine perforation: A case report and literature review |
| title_sort | postpartum choriocarcinoma complicated by uterine perforation a case report and literature review |
| topic | Choriocarcinoma Gestational trophoblastic tumor Postpartum bleeding Uterine perforation Case report |
| url | http://www.sciencedirect.com/science/article/pii/S2214911225000141 |
| work_keys_str_mv | AT rayanrsalahaldin postpartumchoriocarcinomacomplicatedbyuterineperforationacasereportandliteraturereview AT maiseabubaker postpartumchoriocarcinomacomplicatedbyuterineperforationacasereportandliteraturereview AT ghadamabdalqader postpartumchoriocarcinomacomplicatedbyuterineperforationacasereportandliteraturereview AT anasrtuqan postpartumchoriocarcinomacomplicatedbyuterineperforationacasereportandliteraturereview AT baselazaben postpartumchoriocarcinomacomplicatedbyuterineperforationacasereportandliteraturereview AT ibabarghouthi postpartumchoriocarcinomacomplicatedbyuterineperforationacasereportandliteraturereview |