A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology
As an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B exhibits significant antitumor activity again...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1528533/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860983559356416 |
|---|---|
| author | Yanhua Fang Yanhua Fang Juan Pan Piao Wang Piao Wang Ruoyu Wang Shanshan Liang |
| author_facet | Yanhua Fang Yanhua Fang Juan Pan Piao Wang Piao Wang Ruoyu Wang Shanshan Liang |
| author_sort | Yanhua Fang |
| collection | DOAJ |
| description | As an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B exhibits significant antitumor activity against various malignant tumors in preclinical studies, which is achieved by inhibiting cell proliferation and metastasis and promoting apoptosis. As a potential antitumor agent, Schisandrin B holds broad application prospects. This review systematically elaborates on the antitumor effect of Schisandrin B and the related molecular mechanism, and preliminarily predicts its antitumor targets by network pharmacology, thereby pave the way for further research, development, and clinical application. |
| format | Article |
| id | doaj-art-b1632cb0d1764feb919d5f04fa19495f |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-b1632cb0d1764feb919d5f04fa19495f2025-02-10T06:49:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-02-011610.3389/fphar.2025.15285331528533A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacologyYanhua Fang0Yanhua Fang1Juan Pan2Piao Wang3Piao Wang4Ruoyu Wang5Shanshan Liang6The Key Laboratory of biomarker high throughput screening and target translation of breast and gastrointestinal tumor, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, ChinaLiaoning Key Laboratory of Molecular Recognition and Imaging, School of Bioengineering, Dalian University of Technology, Dalian, ChinaThe Key Laboratory of biomarker high throughput screening and target translation of breast and gastrointestinal tumor, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, ChinaThe Key Laboratory of biomarker high throughput screening and target translation of breast and gastrointestinal tumor, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, ChinaDepartment of Oncology, Central Hospital of Liwan, Guangzhou, ChinaThe Key Laboratory of biomarker high throughput screening and target translation of breast and gastrointestinal tumor, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, ChinaThe Key Laboratory of biomarker high throughput screening and target translation of breast and gastrointestinal tumor, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, ChinaAs an active constituent in the extract of dried fruits of Schisandra chinensis, Schisandrin B exhibits diverse pharmacological effects, including liver protection, anti-inflammatory and anti-oxidant. Numerous studies have demonstrated that Schisandrin B exhibits significant antitumor activity against various malignant tumors in preclinical studies, which is achieved by inhibiting cell proliferation and metastasis and promoting apoptosis. As a potential antitumor agent, Schisandrin B holds broad application prospects. This review systematically elaborates on the antitumor effect of Schisandrin B and the related molecular mechanism, and preliminarily predicts its antitumor targets by network pharmacology, thereby pave the way for further research, development, and clinical application.https://www.frontiersin.org/articles/10.3389/fphar.2025.1528533/fullSchisandra chinensisSchisandrin Bantitumormolecular mechanismsnetwork pharmacology |
| spellingShingle | Yanhua Fang Yanhua Fang Juan Pan Piao Wang Piao Wang Ruoyu Wang Shanshan Liang A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology Frontiers in Pharmacology Schisandra chinensis Schisandrin B antitumor molecular mechanisms network pharmacology |
| title | A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology |
| title_full | A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology |
| title_fullStr | A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology |
| title_full_unstemmed | A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology |
| title_short | A comprehensive review of Schisandrin B’s preclinical antitumor activity and mechanistic insights from network pharmacology |
| title_sort | comprehensive review of schisandrin b s preclinical antitumor activity and mechanistic insights from network pharmacology |
| topic | Schisandra chinensis Schisandrin B antitumor molecular mechanisms network pharmacology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1528533/full |
| work_keys_str_mv | AT yanhuafang acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT yanhuafang acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT juanpan acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT piaowang acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT piaowang acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT ruoyuwang acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT shanshanliang acomprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT yanhuafang comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT yanhuafang comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT juanpan comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT piaowang comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT piaowang comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT ruoyuwang comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology AT shanshanliang comprehensivereviewofschisandrinbspreclinicalantitumoractivityandmechanisticinsightsfromnetworkpharmacology |