Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution)
Aim: to review the modern approaches to the diagnosis and treatment of C. difficile-associated disease in adults and present the resolution of the Expert Council held on March 25, 2023 in Moscow.General provisions. C. difficile is the most important nosocomial pathogen which spores are also commonly...
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| Language: | Russian |
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Gastro LLC
2023-08-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/853 |
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| author | V. T. Ivashkin I. V. Maev D. N. Andreev O. V. Goloshchapov A. A. Derinov O. Yu. Zolnikova K. V. Ivashkin O. Yu. Kiseleva A. P. Kiryukhin O. S. Lyashenko E. A. Poluektova A. S. Tertychnyy A. S. Trukhmanov A. I. Ulyanin A. A. Sheptulin O. S. Shifrin |
| author_facet | V. T. Ivashkin I. V. Maev D. N. Andreev O. V. Goloshchapov A. A. Derinov O. Yu. Zolnikova K. V. Ivashkin O. Yu. Kiseleva A. P. Kiryukhin O. S. Lyashenko E. A. Poluektova A. S. Tertychnyy A. S. Trukhmanov A. I. Ulyanin A. A. Sheptulin O. S. Shifrin |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Aim: to review the modern approaches to the diagnosis and treatment of C. difficile-associated disease in adults and present the resolution of the Expert Council held on March 25, 2023 in Moscow.General provisions. C. difficile is the most important nosocomial pathogen which spores are also commonly found in the environment. Microbiota impairment, primarily due to the use of antibacterial drugs, is a key stage in the development of C. difficile-associated disease. A search for an infection should be carried out only in patients with diarrhea, and it is advisable to use at least 2 laboratory methods. The drug of choice for first-line treatment is vancomycin. If drug treatment is ineffective or the patient has recurrent clostridial infection, fecal microbiota transplantation should be considered. The probiotic strain Saccharomyces boulardii CNCM I-745 has a direct inhibitory effect on C. difficile toxin A, promotes normalization of the intestinal microbiota composition, and decreases the inflammatory reaction in colonic mucosa colonized with a toxigenic strain of C. difficile.Conclusions. Addition of the probiotic strain Saccharomyces boulardii CNCM I-745 to antibacterial therapy promotes both primary and secondary prevention of C. difficile-associated disease. |
| format | Article |
| id | doaj-art-b18b3b2fa4364d3792724dc1260a3637 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-08-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-b18b3b2fa4364d3792724dc1260a36372025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-08-01332193310.22416/1382-4376-2023-33-2-19-33543Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution)V. T. Ivashkin0I. V. Maev1D. N. Andreev2O. V. Goloshchapov3A. A. Derinov4O. Yu. Zolnikova5K. V. Ivashkin6O. Yu. Kiseleva7A. P. Kiryukhin8O. S. Lyashenko9E. A. Poluektova10A. S. Tertychnyy11A. S. Trukhmanov12A. I. Ulyanin13A. A. Sheptulin14O. S. Shifrin15I.M. Sechenov First Moscow State Medical University (Sechenov University)A.I. Yevdokimov Moscow State University of Medicine and DentistryA.I. Yevdokimov Moscow State University of Medicine and DentistryI.P. Pavlov First Saint Petersburg State Medical UniversityI.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)I.M. Sechenov First Moscow State Medical University (Sechenov University)Aim: to review the modern approaches to the diagnosis and treatment of C. difficile-associated disease in adults and present the resolution of the Expert Council held on March 25, 2023 in Moscow.General provisions. C. difficile is the most important nosocomial pathogen which spores are also commonly found in the environment. Microbiota impairment, primarily due to the use of antibacterial drugs, is a key stage in the development of C. difficile-associated disease. A search for an infection should be carried out only in patients with diarrhea, and it is advisable to use at least 2 laboratory methods. The drug of choice for first-line treatment is vancomycin. If drug treatment is ineffective or the patient has recurrent clostridial infection, fecal microbiota transplantation should be considered. The probiotic strain Saccharomyces boulardii CNCM I-745 has a direct inhibitory effect on C. difficile toxin A, promotes normalization of the intestinal microbiota composition, and decreases the inflammatory reaction in colonic mucosa colonized with a toxigenic strain of C. difficile.Conclusions. Addition of the probiotic strain Saccharomyces boulardii CNCM I-745 to antibacterial therapy promotes both primary and secondary prevention of C. difficile-associated disease.https://www.gastro-j.ru/jour/article/view/853intestinal microbiotaantibioticsdiarrhea<i>c. difficile</i>pseudomembranous colitisvideo colonoscopyfecal transplantationprobiotics<i>saccharomyces boulardii cncm i-745</i> |
| spellingShingle | V. T. Ivashkin I. V. Maev D. N. Andreev O. V. Goloshchapov A. A. Derinov O. Yu. Zolnikova K. V. Ivashkin O. Yu. Kiseleva A. P. Kiryukhin O. S. Lyashenko E. A. Poluektova A. S. Tertychnyy A. S. Trukhmanov A. I. Ulyanin A. A. Sheptulin O. S. Shifrin Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) Российский журнал гастроэнтерологии, гепатологии, колопроктологии intestinal microbiota antibiotics diarrhea <i>c. difficile</i> pseudomembranous colitis video colonoscopy fecal transplantation probiotics <i>saccharomyces boulardii cncm i-745</i> |
| title | Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) |
| title_full | Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) |
| title_fullStr | Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) |
| title_full_unstemmed | Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) |
| title_short | Modern Approaches to the Diagnosis and treatment of <i>Clostridioides difficile (C. difficile)</i>-associated Disease in Adults (literature Review and Expert Council Resolution) |
| title_sort | modern approaches to the diagnosis and treatment of i clostridioides difficile c difficile i associated disease in adults literature review and expert council resolution |
| topic | intestinal microbiota antibiotics diarrhea <i>c. difficile</i> pseudomembranous colitis video colonoscopy fecal transplantation probiotics <i>saccharomyces boulardii cncm i-745</i> |
| url | https://www.gastro-j.ru/jour/article/view/853 |
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