Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota
Aim. The aim of the review is to present current data on the relationship between non-alcoholic fatty liver disease (NAFLD) with the metabolic disorders of bile acids (BA) and changes in the composition of the intestinal microbiota.Background. NAFLD is accompanied by a change in the intestinal mic...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2018-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/255 |
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| author | R. V. Maslennikov Yu. V. Evsyutina |
| author_facet | R. V. Maslennikov Yu. V. Evsyutina |
| author_sort | R. V. Maslennikov |
| collection | DOAJ |
| description | Aim. The aim of the review is to present current data on the relationship between non-alcoholic fatty liver disease (NAFLD) with the metabolic disorders of bile acids (BA) and changes in the composition of the intestinal microbiota.Background. NAFLD is accompanied by a change in the intestinal microbiotic composition: the proportion of taxa deconjugating BAs increases, while the proportion of taxa converting primary BAs to secondary ones decreases. The number of bacteria forming lipopolysaccharide (LPS) also increases. LPS, entering the liver with the portal vein blood, promotes the development of its inflammation and insulin resistance. The disturbance of bile acid metabolism through the effect on the FXR and TGR5 receptors also leads to insulin resistance and liver steatosis. FXR probiotics and agonists are promising drugs for the NAFLD treatment.Conclusion. In the course of NAFLD, a change in the composition of the intestinal microbiota is observed, which contributes to the development of inflammation in the liver and disrupts the metabolism of bile acids, leading to insulin resistance. |
| format | Article |
| id | doaj-art-b18d32740d4141c382df17f7f8520a59 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2018-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-b18d32740d4141c382df17f7f8520a592025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732018-09-01284849010.22416/1382-4376-2018-28-4-84-90255Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal MicrobiotaR. V. Maslennikov0Yu. V. Evsyutina1I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Healthcare of the Russian FederationNational Research Center for Preventive MedicineAim. The aim of the review is to present current data on the relationship between non-alcoholic fatty liver disease (NAFLD) with the metabolic disorders of bile acids (BA) and changes in the composition of the intestinal microbiota.Background. NAFLD is accompanied by a change in the intestinal microbiotic composition: the proportion of taxa deconjugating BAs increases, while the proportion of taxa converting primary BAs to secondary ones decreases. The number of bacteria forming lipopolysaccharide (LPS) also increases. LPS, entering the liver with the portal vein blood, promotes the development of its inflammation and insulin resistance. The disturbance of bile acid metabolism through the effect on the FXR and TGR5 receptors also leads to insulin resistance and liver steatosis. FXR probiotics and agonists are promising drugs for the NAFLD treatment.Conclusion. In the course of NAFLD, a change in the composition of the intestinal microbiota is observed, which contributes to the development of inflammation in the liver and disrupts the metabolism of bile acids, leading to insulin resistance.https://www.gastro-j.ru/jour/article/view/255intestinal microbiotabile acidsinsulin resistancenon-alcoholic fatty liver diseasesteatohepatitis |
| spellingShingle | R. V. Maslennikov Yu. V. Evsyutina Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota Российский журнал гастроэнтерологии, гепатологии, колопроктологии intestinal microbiota bile acids insulin resistance non-alcoholic fatty liver disease steatohepatitis |
| title | Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota |
| title_full | Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota |
| title_fullStr | Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota |
| title_full_unstemmed | Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota |
| title_short | Non-Alcoholic Fatty Liver Disease, Bile Acids and Intestinal Microbiota |
| title_sort | non alcoholic fatty liver disease bile acids and intestinal microbiota |
| topic | intestinal microbiota bile acids insulin resistance non-alcoholic fatty liver disease steatohepatitis |
| url | https://www.gastro-j.ru/jour/article/view/255 |
| work_keys_str_mv | AT rvmaslennikov nonalcoholicfattyliverdiseasebileacidsandintestinalmicrobiota AT yuvevsyutina nonalcoholicfattyliverdiseasebileacidsandintestinalmicrobiota |