Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis
Hyperimmunoglobulin E syndrome (HIGES) is a rare immunodeficiency characterized by high levels of immunoglobulin E (IgE) in the setting of various clinical features such as cutaneous candidiasis, asthma, recurrent rashes, and fungal infections. This case describes a 70-year-old male with cachexia an...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007124001722 |
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| author | Joseph Nordin Stephen Smetana Rachel Johnson Angela Bartosiak Nicholas Nassif |
| author_facet | Joseph Nordin Stephen Smetana Rachel Johnson Angela Bartosiak Nicholas Nassif |
| author_sort | Joseph Nordin |
| collection | DOAJ |
| description | Hyperimmunoglobulin E syndrome (HIGES) is a rare immunodeficiency characterized by high levels of immunoglobulin E (IgE) in the setting of various clinical features such as cutaneous candidiasis, asthma, recurrent rashes, and fungal infections. This case describes a 70-year-old male with cachexia and dyspnea found to have a cavitary lesion and aspergilloma, with remarkably high IgE and positive 1,3-β-D-glucan and Aspergillus testing. Herein, we describe the aforementioned case, review the available literature, and hypothesize the connection between invasive fungal infections and HIGES. We hope this discussion helps highlight the importance of a broad differential in chronic dyspnea, including infectious etiologies, and allows for a better understanding of immunologic labs in the setting of fungal infections. |
| format | Article |
| id | doaj-art-b2062e3c9f0046f7a76d6dd779d97590 |
| institution | Kabale University |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-b2062e3c9f0046f7a76d6dd779d975902025-02-09T05:00:17ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-0153102149Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosisJoseph Nordin0Stephen Smetana1Rachel Johnson2Angela Bartosiak3Nicholas Nassif4Aurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USAAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USAAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USAAurora Health Care, 945 N, 12th Street, 5th Floor, Internal Medicine Clinic, Milwaukee, WI, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; Corresponding author.Hyperimmunoglobulin E syndrome (HIGES) is a rare immunodeficiency characterized by high levels of immunoglobulin E (IgE) in the setting of various clinical features such as cutaneous candidiasis, asthma, recurrent rashes, and fungal infections. This case describes a 70-year-old male with cachexia and dyspnea found to have a cavitary lesion and aspergilloma, with remarkably high IgE and positive 1,3-β-D-glucan and Aspergillus testing. Herein, we describe the aforementioned case, review the available literature, and hypothesize the connection between invasive fungal infections and HIGES. We hope this discussion helps highlight the importance of a broad differential in chronic dyspnea, including infectious etiologies, and allows for a better understanding of immunologic labs in the setting of fungal infections.http://www.sciencedirect.com/science/article/pii/S2213007124001722 |
| spellingShingle | Joseph Nordin Stephen Smetana Rachel Johnson Angela Bartosiak Nicholas Nassif Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis Respiratory Medicine Case Reports |
| title | Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis |
| title_full | Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis |
| title_fullStr | Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis |
| title_full_unstemmed | Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis |
| title_short | Break through the mold: Hyper-IgE syndrome as a vehicle for invasive aspergillosis |
| title_sort | break through the mold hyper ige syndrome as a vehicle for invasive aspergillosis |
| url | http://www.sciencedirect.com/science/article/pii/S2213007124001722 |
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