The role of probiotics in ameliorating hyperuricemia: a review
Hyperuricemia (HUA) is a metabolic disorder syndrome caused by purine metabolism dysregulation, and its prevalence increases year by year. The development and progression of HUA are accompanied by significant alterations in the composition of intestinal microbiota, making probiotics a potential and...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of China Preventive Medicine Journal
2025-01-01
|
| Series: | 预防医学 |
| Subjects: | |
| Online Access: | http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.01.008 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206742821109760 |
|---|---|
| author | ZOU Yan, HUANG Enshan, ZHAO Dong, HUANG Lichun, SU Danting, ZHANG Ronghua |
| author_facet | ZOU Yan, HUANG Enshan, ZHAO Dong, HUANG Lichun, SU Danting, ZHANG Ronghua |
| author_sort | ZOU Yan, HUANG Enshan, ZHAO Dong, HUANG Lichun, SU Danting, ZHANG Ronghua |
| collection | DOAJ |
| description | Hyperuricemia (HUA) is a metabolic disorder syndrome caused by purine metabolism dysregulation, and its prevalence increases year by year. The development and progression of HUA are accompanied by significant alterations in the composition of intestinal microbiota, making probiotics a potential and safe method to reduce serum uric acid. Probiotics ameliorate HUA through three pathways: competing with intestinal epithelial cells for purine absorption to decrease uric acid synthesis, inhibiting xanthine oxidase activity through modulation of inflammatory cytokines to reduce the conversion of purine to uric acid, as well as restoring and maintaining an orderly state of the gut microbiota to facilitate normal uric acid excretion. This article reviews the role of probiotics in ameliorating HUA, so as to provide the reference for the application of probiotics in the prevention and intervention of HUA. |
| format | Article |
| id | doaj-art-b208f804405a403cbb6db91f25042868 |
| institution | Kabale University |
| issn | 2096-5087 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of China Preventive Medicine Journal |
| record_format | Article |
| series | 预防医学 |
| spelling | doaj-art-b208f804405a403cbb6db91f250428682025-02-07T06:32:54ZzhoEditorial Office of China Preventive Medicine Journal预防医学2096-50872025-01-01371363910.19485/j.cnki.issn2096-5087.2025.01.008The role of probiotics in ameliorating hyperuricemia: a reviewZOU Yan, HUANG Enshan, ZHAO Dong, HUANG Lichun, SU Danting, ZHANG RonghuaHyperuricemia (HUA) is a metabolic disorder syndrome caused by purine metabolism dysregulation, and its prevalence increases year by year. The development and progression of HUA are accompanied by significant alterations in the composition of intestinal microbiota, making probiotics a potential and safe method to reduce serum uric acid. Probiotics ameliorate HUA through three pathways: competing with intestinal epithelial cells for purine absorption to decrease uric acid synthesis, inhibiting xanthine oxidase activity through modulation of inflammatory cytokines to reduce the conversion of purine to uric acid, as well as restoring and maintaining an orderly state of the gut microbiota to facilitate normal uric acid excretion. This article reviews the role of probiotics in ameliorating HUA, so as to provide the reference for the application of probiotics in the prevention and intervention of HUA.http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.01.008probioticshyperuricemiagut microbiota |
| spellingShingle | ZOU Yan, HUANG Enshan, ZHAO Dong, HUANG Lichun, SU Danting, ZHANG Ronghua The role of probiotics in ameliorating hyperuricemia: a review 预防医学 probiotics hyperuricemia gut microbiota |
| title | The role of probiotics in ameliorating hyperuricemia: a review |
| title_full | The role of probiotics in ameliorating hyperuricemia: a review |
| title_fullStr | The role of probiotics in ameliorating hyperuricemia: a review |
| title_full_unstemmed | The role of probiotics in ameliorating hyperuricemia: a review |
| title_short | The role of probiotics in ameliorating hyperuricemia: a review |
| title_sort | role of probiotics in ameliorating hyperuricemia a review |
| topic | probiotics hyperuricemia gut microbiota |
| url | http://www.zjyfyxzz.com/CN/10.19485/j.cnki.issn2096-5087.2025.01.008 |
| work_keys_str_mv | AT zouyanhuangenshanzhaodonghuanglichunsudantingzhangronghua theroleofprobioticsinamelioratinghyperuricemiaareview AT zouyanhuangenshanzhaodonghuanglichunsudantingzhangronghua roleofprobioticsinamelioratinghyperuricemiaareview |