Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes
Background: Treatment decisions after diagnosis of clinically localized prostate cancer are difficult due to variability in tumor behavior. As there is a high prevalence of low-grade prostate cancer with an indolent course, we need improved markers of prostate cancer lethality in order to reduce the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_171_22 |
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| _version_ | 1825205473272397824 |
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| author | Sumaira Siddiqui |
| author_facet | Sumaira Siddiqui |
| author_sort | Sumaira Siddiqui |
| collection | DOAJ |
| description | Background:
Treatment decisions after diagnosis of clinically localized prostate cancer are difficult due to variability in tumor behavior. As there is a high prevalence of low-grade prostate cancer with an indolent course, we need improved markers of prostate cancer lethality in order to reduce the overtreatment. In the current study, we assessed Ki-67 expression in cases of prostate carcinoma and correlated its expression with clinical outcomes.
Materials and Methods:
It was a single-center retrospective descriptive type of study. A total of 50 cases were included. Diagnosed cases of adenocarcinoma on Transurethral Resection of the Prostate (TURP) chips and Trucut prostatic biopsies (Archival biopsy specimens) for whom five years follow-up was available from record files and/or telephonic interviews were included. The clinical outcomes (rate of distant metastases, disease specific survival, and overall survival) over a period of five years were recorded.
Results:
In the current study, 78% of the cases of carcinoma prostate were positive for Ki-67 expression. The mean Ki-67 staining index was 15.22% among the cases. The cases with High Ki-67 Staining index had a significantly higher rate of distant metastasis, poor disease-specific survival, and overall survival compared to cases with low Ki-67 staining index.
Conclusion:
Ki-67 can be used along with the other established prognostic parameters to assess the lethality of prostate cancer. |
| format | Article |
| id | doaj-art-b25751c1e910402080bc3bfe5015e2f9 |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-b25751c1e910402080bc3bfe5015e2f92025-02-07T13:57:54ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167236236610.4103/ijpm.ijpm_171_22Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomesSumaira SiddiquiBackground: Treatment decisions after diagnosis of clinically localized prostate cancer are difficult due to variability in tumor behavior. As there is a high prevalence of low-grade prostate cancer with an indolent course, we need improved markers of prostate cancer lethality in order to reduce the overtreatment. In the current study, we assessed Ki-67 expression in cases of prostate carcinoma and correlated its expression with clinical outcomes. Materials and Methods: It was a single-center retrospective descriptive type of study. A total of 50 cases were included. Diagnosed cases of adenocarcinoma on Transurethral Resection of the Prostate (TURP) chips and Trucut prostatic biopsies (Archival biopsy specimens) for whom five years follow-up was available from record files and/or telephonic interviews were included. The clinical outcomes (rate of distant metastases, disease specific survival, and overall survival) over a period of five years were recorded. Results: In the current study, 78% of the cases of carcinoma prostate were positive for Ki-67 expression. The mean Ki-67 staining index was 15.22% among the cases. The cases with High Ki-67 Staining index had a significantly higher rate of distant metastasis, poor disease-specific survival, and overall survival compared to cases with low Ki-67 staining index. Conclusion: Ki-67 can be used along with the other established prognostic parameters to assess the lethality of prostate cancer.https://journals.lww.com/10.4103/ijpm.ijpm_171_22disease-specific survivaldistant metastasiski-67overall survivalprostatic cancer |
| spellingShingle | Sumaira Siddiqui Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes Indian Journal of Pathology and Microbiology disease-specific survival distant metastasis ki-67 overall survival prostatic cancer |
| title | Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes |
| title_full | Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes |
| title_fullStr | Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes |
| title_full_unstemmed | Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes |
| title_short | Assessment of Ki-67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes |
| title_sort | assessment of ki 67 expression in cases of prostatic carcinoma and its correlation with clinical outcomes |
| topic | disease-specific survival distant metastasis ki-67 overall survival prostatic cancer |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_171_22 |
| work_keys_str_mv | AT sumairasiddiqui assessmentofki67expressionincasesofprostaticcarcinomaanditscorrelationwithclinicaloutcomes |