Constipation at endocrine diseases
The aim of review. To demonstrate main causes of constipation at various endocrine diseases, to present general approach to constipation treatment at endocrine diseases.Key points. Defecation disorders on a background of endocrine diseases are regarded as secondary, symptomatic disorders. Constipati...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2013-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1195 |
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| Summary: | The aim of review. To demonstrate main causes of constipation at various endocrine diseases, to present general approach to constipation treatment at endocrine diseases.Key points. Defecation disorders on a background of endocrine diseases are regarded as secondary, symptomatic disorders. Constipation is a characteristic component of such endocrine syndromes, as diabetes mellitus (DM), hypothyroidism, hyperparathyroidism, hypopituitarism, pheochromocytoma, hyperaldosteronism, Addison's disease. DM occupies a leading place among them. Gastro-intestinal motility disorder at this syndrome is related to development of diabetic autonomous neuropathy, asynchrony of peristalsis and pressure of sphincters, acute decrease of cells of Cajal density, change of gastrointestinal hormones secretion. Constipation is typical symptom of hypothyroidism. Severe hypothyroidism can result in dynamic ileus and megacolon. Constipation is one of broad spectrum of gastro-intestinal hyperthyroidism manifestations, probably, related to change in expression of the genes regulating motility, decrease of autonomous nervous system excitability and dehydration. Decrease of enterochromaffin cells number and change of intestinal nervous ganglia structure is typical for hereditary endocrine syndromes (APECED, MEN-2). Disorders of defecation are observed at adrenal insufficiency (alternates with diarrhea), hyperaldosteronism, hypopituitarism, changes of sexual hormones secretion, hyperinsulinemia. Laxatives, including volume and osmotic laxatives, stimulating drugs, are prescribed in absence of response to nonpharmaceutical procedures.Conclusion. Disorders of defecation is a characteristic symptom of the most common endocrine diseases; at some from them constipation alternates with diarrhea. Many endocrine diseases are oligosymptomatic for a long time. Doctor should pay special attention to constipation development and try to find other concomitant signs indicating systemic nature of disease. stepwise treatment of constipation is necessary. |
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| ISSN: | 1382-4376 2658-6673 |