Focused ultrasound for treatment of peripheral brain tumors
Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemoth...
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| Format: | Article |
| Language: | English |
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Open Exploration
2023-04-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A10089/10089.pdf |
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| author | Phillip Mitchell Johansen Payton Yerke Hansen Ali A. Mohamed Sarah J. Girshfeld Marc Feldmann Brandon Lucke-Wold |
| author_facet | Phillip Mitchell Johansen Payton Yerke Hansen Ali A. Mohamed Sarah J. Girshfeld Marc Feldmann Brandon Lucke-Wold |
| author_sort | Phillip Mitchell Johansen |
| collection | DOAJ |
| description | Malignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. However, the therapeutic efficacy of chemotherapeutic agents is limited due to the blood-brain barrier (BBB). Magnetic resonance guided focused ultrasound (MRgFUS) is a new and promising intervention for CNS tumors, which has shown success in preclinical trials. High-intensity focused ultrasound (HIFU) has the capacity to serve as a direct therapeutic agent in the form of thermoablation and mechanical destruction of the tumor. Low-intensity focused ultrasound (LIFU) has been shown to disrupt the BBB and enhance the uptake of therapeutic agents in the brain and CNS. The authors present a review of MRgFUS in the treatment of CNS tumors. This treatment method has shown promising results in preclinical trials including minimal adverse effects, increased infiltration of the therapeutic agents into the CNS, decreased tumor progression, and improved survival rates. |
| format | Article |
| id | doaj-art-b2b8aaee2fc44a92b8498999b9fee9c9 |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-b2b8aaee2fc44a92b8498999b9fee9c92025-02-08T05:16:47ZengOpen ExplorationExploration of Drug Science2836-76772023-04-011210712510.37349/eds.2023.00009Focused ultrasound for treatment of peripheral brain tumorsPhillip Mitchell Johansen0https://orcid.org/0000-0003-1638-2325Payton Yerke Hansen1https://orcid.org/0000-0003-0195-2524Ali A. Mohamed2https://orcid.org/0000-0002-0977-0365Sarah J. Girshfeld3https://orcid.org/0009-0006-9029-2933Marc Feldmann4Brandon Lucke-Wold5https://orcid.org/0000-0001-6577-4080Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USACharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USACharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USACharles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL 33431, USACollege of Medicine, University of Florida, Gainesville, FL 32611, USADepartment of Neurosurgery, University of Florida, Gainesville, FL 32611, USAMalignant brain tumors are the leading cause of cancer-related death in children and remain a significant cause of morbidity and mortality throughout all demographics. Central nervous system (CNS) tumors are classically treated with surgical resection and radiotherapy in addition to adjuvant chemotherapy. However, the therapeutic efficacy of chemotherapeutic agents is limited due to the blood-brain barrier (BBB). Magnetic resonance guided focused ultrasound (MRgFUS) is a new and promising intervention for CNS tumors, which has shown success in preclinical trials. High-intensity focused ultrasound (HIFU) has the capacity to serve as a direct therapeutic agent in the form of thermoablation and mechanical destruction of the tumor. Low-intensity focused ultrasound (LIFU) has been shown to disrupt the BBB and enhance the uptake of therapeutic agents in the brain and CNS. The authors present a review of MRgFUS in the treatment of CNS tumors. This treatment method has shown promising results in preclinical trials including minimal adverse effects, increased infiltration of the therapeutic agents into the CNS, decreased tumor progression, and improved survival rates.https://www.explorationpub.com/uploads/Article/A10089/10089.pdflow-intensity focused ultrasoundhigh-intensity focused ultrasoundmagnetic resonance guided focused ultrasoundmagnetic resonance-guided therapyglioblastoma |
| spellingShingle | Phillip Mitchell Johansen Payton Yerke Hansen Ali A. Mohamed Sarah J. Girshfeld Marc Feldmann Brandon Lucke-Wold Focused ultrasound for treatment of peripheral brain tumors Exploration of Drug Science low-intensity focused ultrasound high-intensity focused ultrasound magnetic resonance guided focused ultrasound magnetic resonance-guided therapy glioblastoma |
| title | Focused ultrasound for treatment of peripheral brain tumors |
| title_full | Focused ultrasound for treatment of peripheral brain tumors |
| title_fullStr | Focused ultrasound for treatment of peripheral brain tumors |
| title_full_unstemmed | Focused ultrasound for treatment of peripheral brain tumors |
| title_short | Focused ultrasound for treatment of peripheral brain tumors |
| title_sort | focused ultrasound for treatment of peripheral brain tumors |
| topic | low-intensity focused ultrasound high-intensity focused ultrasound magnetic resonance guided focused ultrasound magnetic resonance-guided therapy glioblastoma |
| url | https://www.explorationpub.com/uploads/Article/A10089/10089.pdf |
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