The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice
Background: High blood sugar levels that exceed normal limits or commonly refered to as hyperglycemia, is an early symptom of diabetes mellitus. Objectives: This study explored the effect of lemon (Citrus limon) extract on blood sugar levels and pancreatic b cell regeneration in alloxan-induced...
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Indonesian Society for Biochemistry and Molecular Biology
2023-08-01
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| Series: | Acta Biochimica Indonesiana |
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| Online Access: | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/97 |
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| author | Petrus Mantur Efrisca Meliyuita Br. Damanik Elisabeth Levina Sari Setianingrum Prisca Pakan |
| author_facet | Petrus Mantur Efrisca Meliyuita Br. Damanik Elisabeth Levina Sari Setianingrum Prisca Pakan |
| author_sort | Petrus Mantur |
| collection | DOAJ |
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Background: High blood sugar levels that exceed normal limits or commonly refered to as hyperglycemia, is an early symptom of diabetes mellitus.
Objectives: This study explored the effect of lemon (Citrus limon) extract on blood sugar levels and pancreatic b cell regeneration in alloxan-induced hyperglycemic mice (Mus musculus).
Method: This research is an experimental study using a post-test group. The sampling was carried out using a randomization method. By administering 125 mg/kg BW of alloxan, the sample was conditioned for hyperglycemia. The samples were divided into five groups: normal control, alloxan-induced control, and three treatment groups that received lemon extract with dosages of 100 mg/kg BW, 300 mg/kg BW and 500 mg/kg BW, respectively. Semiquantitative analysis was used to evaluate pancreatic damage.
Results: The results showed that lemon extract can decrease blood sugar levels. Histopathological imaging revealed a significant improvement in b cell distribution and decreased vacuolization in the Langerhans islets of mice administered lemon extract. No significant differences were observed among different dosages of lemon extract (p>0.05).
Conclusion: Our findings underscore the potential therapeutic benefits of lemon extract in managing blood sugar levels and promoting pancreatic b cell regeneration in alloxan-induced mice.
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| format | Article |
| id | doaj-art-b3a529031af94762a9f4430d89713010 |
| institution | Kabale University |
| issn | 2654-6108 2654-3222 |
| language | English |
| publishDate | 2023-08-01 |
| publisher | Indonesian Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | Acta Biochimica Indonesiana |
| spelling | doaj-art-b3a529031af94762a9f4430d897130102025-02-08T03:05:55ZengIndonesian Society for Biochemistry and Molecular BiologyActa Biochimica Indonesiana2654-61082654-32222023-08-016110.32889/actabiona.97The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic micePetrus Mantur0Efrisca Meliyuita Br. Damanik1Elisabeth Levina Sari Setianingrum2Prisca Pakan3Medicine Program, Faculty of Medicine and Veterinary Science, Universitas Nusa CendanaDepartment of Anatomical Pathology of Medicine Program, Faculty of Medicine and Veterinary Science, Universitas Nusa CendanaDepartment of Clinical Pathology of Medicine Program, Faculty of Medicine and Veterinary Science, Universitas Nusa CendanaDepartment of Microbiology of Medicine Program, Faculty of Medicine and Veterinary Science, Universitas Nusa Cendana Background: High blood sugar levels that exceed normal limits or commonly refered to as hyperglycemia, is an early symptom of diabetes mellitus. Objectives: This study explored the effect of lemon (Citrus limon) extract on blood sugar levels and pancreatic b cell regeneration in alloxan-induced hyperglycemic mice (Mus musculus). Method: This research is an experimental study using a post-test group. The sampling was carried out using a randomization method. By administering 125 mg/kg BW of alloxan, the sample was conditioned for hyperglycemia. The samples were divided into five groups: normal control, alloxan-induced control, and three treatment groups that received lemon extract with dosages of 100 mg/kg BW, 300 mg/kg BW and 500 mg/kg BW, respectively. Semiquantitative analysis was used to evaluate pancreatic damage. Results: The results showed that lemon extract can decrease blood sugar levels. Histopathological imaging revealed a significant improvement in b cell distribution and decreased vacuolization in the Langerhans islets of mice administered lemon extract. No significant differences were observed among different dosages of lemon extract (p>0.05). Conclusion: Our findings underscore the potential therapeutic benefits of lemon extract in managing blood sugar levels and promoting pancreatic b cell regeneration in alloxan-induced mice. https://pbbmi.org/newjurnal/index.php/actabioina/article/view/97hyperglycemiadiabetes mellituslemonalloxan |
| spellingShingle | Petrus Mantur Efrisca Meliyuita Br. Damanik Elisabeth Levina Sari Setianingrum Prisca Pakan The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice Acta Biochimica Indonesiana hyperglycemia diabetes mellitus lemon alloxan |
| title | The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice |
| title_full | The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice |
| title_fullStr | The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice |
| title_full_unstemmed | The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice |
| title_short | The effect of lemon extract (Citrus limon) on the blood sugar levels and pancreatic beta cell regeneration in alloxan-induced hyperglycemic mice |
| title_sort | effect of lemon extract citrus limon on the blood sugar levels and pancreatic beta cell regeneration in alloxan induced hyperglycemic mice |
| topic | hyperglycemia diabetes mellitus lemon alloxan |
| url | https://pbbmi.org/newjurnal/index.php/actabioina/article/view/97 |
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