Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production
This study was designed to assess the effectiveness of an authorized commercial standardized mixture of Artepillin-C, methyl-salicylates, flavonoids and curcuminoids (PHYTO AX'CELL™) provided intermittently during 8 weeks (wk) of trial to laying hens raised in enriched cages during the peak of...
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Elsevier
2025-03-01
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| Series: | Poultry Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579125001191 |
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| author | Alessandro Guerrini Roberta Salaroli Augusta Zannoni Giancarlo Avallone Francesca Leone Valentina Serra Giulia Quaglia Francesca del Zozzo Thibaut Chabrillat Claire Carlu Caterina Lupini Doriana Eurosia Angela Tedesco |
| author_facet | Alessandro Guerrini Roberta Salaroli Augusta Zannoni Giancarlo Avallone Francesca Leone Valentina Serra Giulia Quaglia Francesca del Zozzo Thibaut Chabrillat Claire Carlu Caterina Lupini Doriana Eurosia Angela Tedesco |
| author_sort | Alessandro Guerrini |
| collection | DOAJ |
| description | This study was designed to assess the effectiveness of an authorized commercial standardized mixture of Artepillin-C, methyl-salicylates, flavonoids and curcuminoids (PHYTO AX'CELL™) provided intermittently during 8 weeks (wk) of trial to laying hens raised in enriched cages during the peak of the production, in the reduction of inflammation status, improving the immune response, and egg quality. In this study, 764 Lohmann LSL-White hens on the first day (d) of the 26th wk of age (T0), were randomly assigned to 2 replicated experimental groups, control and treated (n=382 each). The treatment was supplied in drinking water, as follows: 26th to 27th wk (T1, 14 d) first treatment administration at a dose of 1 mL/L (0.5 mL/L only the first d of the treatment); 28th to the 31st wk (T2, 4 wk of withdrawal period); 32nd to 33rd wk (T3, 14 d) second treatment at a dose of 1 mL/L, until the end of the trial (T4). At T0, mid-T3 and T4, 13 hens per group were sampled for serum biochemical analyses (metabolic profile, H/L ratio) and weighed, and 60 eggs per group were analyzed for quality parameters. At T4, 13 hens per group were sacrificed for histological investigations and gut IgA quantification. The treatment reduced the mortality rate in the treated group (0.00%) compared to the control (2.61%). An improvement in intestinal IgA production and immune reactivity in the treated hens was observed with a significant fluctuating trend of the heterophil, lymphocyte and their ratio (P < 0.05). The egg quality was improved by the treatment, with positive effects in the Haugh unit, shell weight and thickness (P < 0.05). A T4, significant reduction in duodenal and rectal pH was observed in the treated group (P < 0.05), without intestinal inflammation score changes, body weight, serum biochemistry, interleukin levels, and infectious bronchitis virus titers (P > 0.05). From the results, PHYTO AX'CELL™ improved the well-being and physical condition of laying hens raised in cages, modulating the immune system with a positive production of intestinal IgA, and egg quality parameters important for commercial purposes. |
| format | Article |
| id | doaj-art-b49bccc687dd440cb2d9dea9b1a56f1e |
| institution | Kabale University |
| issn | 0032-5791 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
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| series | Poultry Science |
| spelling | doaj-art-b49bccc687dd440cb2d9dea9b1a56f1e2025-02-08T04:59:18ZengElsevierPoultry Science0032-57912025-03-011043104882Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of productionAlessandro Guerrini0Roberta Salaroli1Augusta Zannoni2Giancarlo Avallone3Francesca Leone4Valentina Serra5Giulia Quaglia6Francesca del Zozzo7Thibaut Chabrillat8Claire Carlu9Caterina Lupini10Doriana Eurosia Angela Tedesco11Department of Environmental Science and Policy, University of Milan, Via Celoria 10, 20133, Milan (MI), Italy; Corresponding author at: Department of Environmental Science and Policy, University of Milan, Via Celoria 10, 20133 Milan, Italy.Department of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (BO), ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (BO), ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (BO), ItalyDepartment of Environmental Science and Policy, University of Milan, Via Celoria 10, 20133, Milan (MI), ItalyDepartment of Veterinary Medicine and Animal Science, University of Milan, Via dell' Università 6, 26900, Lodi, ItalyDepartment of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (BO), ItalyChemifarma S.p.a, Via Don Eugenio Servadei, 16, 47122, Forlì-Cesena (FC), ItalyPhytosynthese, Avenue Jean Jaurès, 57, 63200, Mozac, FrancePhytosynthese, Avenue Jean Jaurès, 57, 63200, Mozac, FranceDepartment of Veterinary Medical Sciences, University of Bologna, Via Tolara di Sopra 50, 40064, Ozzano dell'Emilia (BO), ItalyDepartment of Environmental Science and Policy, University of Milan, Via Celoria 10, 20133, Milan (MI), ItalyThis study was designed to assess the effectiveness of an authorized commercial standardized mixture of Artepillin-C, methyl-salicylates, flavonoids and curcuminoids (PHYTO AX'CELL™) provided intermittently during 8 weeks (wk) of trial to laying hens raised in enriched cages during the peak of the production, in the reduction of inflammation status, improving the immune response, and egg quality. In this study, 764 Lohmann LSL-White hens on the first day (d) of the 26th wk of age (T0), were randomly assigned to 2 replicated experimental groups, control and treated (n=382 each). The treatment was supplied in drinking water, as follows: 26th to 27th wk (T1, 14 d) first treatment administration at a dose of 1 mL/L (0.5 mL/L only the first d of the treatment); 28th to the 31st wk (T2, 4 wk of withdrawal period); 32nd to 33rd wk (T3, 14 d) second treatment at a dose of 1 mL/L, until the end of the trial (T4). At T0, mid-T3 and T4, 13 hens per group were sampled for serum biochemical analyses (metabolic profile, H/L ratio) and weighed, and 60 eggs per group were analyzed for quality parameters. At T4, 13 hens per group were sacrificed for histological investigations and gut IgA quantification. The treatment reduced the mortality rate in the treated group (0.00%) compared to the control (2.61%). An improvement in intestinal IgA production and immune reactivity in the treated hens was observed with a significant fluctuating trend of the heterophil, lymphocyte and their ratio (P < 0.05). The egg quality was improved by the treatment, with positive effects in the Haugh unit, shell weight and thickness (P < 0.05). A T4, significant reduction in duodenal and rectal pH was observed in the treated group (P < 0.05), without intestinal inflammation score changes, body weight, serum biochemistry, interleukin levels, and infectious bronchitis virus titers (P > 0.05). From the results, PHYTO AX'CELL™ improved the well-being and physical condition of laying hens raised in cages, modulating the immune system with a positive production of intestinal IgA, and egg quality parameters important for commercial purposes.http://www.sciencedirect.com/science/article/pii/S0032579125001191Hen welfarePlant bioactive compoundsEgg productionGut healthInflammatory markers |
| spellingShingle | Alessandro Guerrini Roberta Salaroli Augusta Zannoni Giancarlo Avallone Francesca Leone Valentina Serra Giulia Quaglia Francesca del Zozzo Thibaut Chabrillat Claire Carlu Caterina Lupini Doriana Eurosia Angela Tedesco Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production Poultry Science Hen welfare Plant bioactive compounds Egg production Gut health Inflammatory markers |
| title | Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production |
| title_full | Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production |
| title_fullStr | Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production |
| title_full_unstemmed | Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production |
| title_short | Immunomodulatory and anti-inflammatory potential of botanicals bioactive product (PHYTO AX'CELL™) for an improvement of the well-being of laying hens at the peak of production |
| title_sort | immunomodulatory and anti inflammatory potential of botanicals bioactive product phyto ax cell™ for an improvement of the well being of laying hens at the peak of production |
| topic | Hen welfare Plant bioactive compounds Egg production Gut health Inflammatory markers |
| url | http://www.sciencedirect.com/science/article/pii/S0032579125001191 |
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