Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease
The aim of publication. To present up-to-date data on the role of disorders of motor function of the esophagus in development of gastroesophageal reflux disease and mechanisms of transient lower esophageal sphincter relaxations (TLESR) on functional activity of antireflux barrier.Original positions....
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1507 |
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| author | V. T. Ivashkin A. S. Trukhmanov |
| author_facet | V. T. Ivashkin A. S. Trukhmanov |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | The aim of publication. To present up-to-date data on the role of disorders of motor function of the esophagus in development of gastroesophageal reflux disease and mechanisms of transient lower esophageal sphincter relaxations (TLESR) on functional activity of antireflux barrier.Original positions. There are several components of TLESR mechanism: decrease of the lower esophageal sphincter pressure, modulated by inhibiting impulses; decrease of compression by crures of diaphragm; intensive contraction of longitudinal muscles of the esophagus; relaxation of circular musculature layer at its distal part. There are differences in TLESR mechanism between healthy persons and patients with gastroesophageal reflux disease (GERD) i.e.: at healthy subjects only gas enters the esophagus from the stomach during TLESR in contrast to patients with reflux disease. Obesity increases potential of TLESR appearance, associated with reflux of liquid contents from the stomach.Conclusion. Taking into account comprehension of available regulatory parts, reality of influence on esophageal motility and especially LES is tempting. Studying of this function opens encouraging prospects of improvement of treatment of GERD. |
| format | Article |
| id | doaj-art-b4f95a6926b448c5ae666a42467ca84c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-b4f95a6926b448c5ae666a42467ca84c2025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-04-0120213191021Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux diseaseV. T. IvashkinA. S. TrukhmanovThe aim of publication. To present up-to-date data on the role of disorders of motor function of the esophagus in development of gastroesophageal reflux disease and mechanisms of transient lower esophageal sphincter relaxations (TLESR) on functional activity of antireflux barrier.Original positions. There are several components of TLESR mechanism: decrease of the lower esophageal sphincter pressure, modulated by inhibiting impulses; decrease of compression by crures of diaphragm; intensive contraction of longitudinal muscles of the esophagus; relaxation of circular musculature layer at its distal part. There are differences in TLESR mechanism between healthy persons and patients with gastroesophageal reflux disease (GERD) i.e.: at healthy subjects only gas enters the esophagus from the stomach during TLESR in contrast to patients with reflux disease. Obesity increases potential of TLESR appearance, associated with reflux of liquid contents from the stomach.Conclusion. Taking into account comprehension of available regulatory parts, reality of influence on esophageal motility and especially LES is tempting. Studying of this function opens encouraging prospects of improvement of treatment of GERD.https://www.gastro-j.ru/jour/article/view/1507gastroesophageal reflux diseasetransient relaxations of lower esophageal sphinctertreatment of motor disorders |
| spellingShingle | V. T. Ivashkin A. S. Trukhmanov Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии gastroesophageal reflux disease transient relaxations of lower esophageal sphincter treatment of motor disorders |
| title | Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease |
| title_full | Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease |
| title_fullStr | Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease |
| title_full_unstemmed | Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease |
| title_short | Evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease |
| title_sort | evolution of concept of esophageal motor disturbances in pathogenesis of gastroesophageal reflux disease |
| topic | gastroesophageal reflux disease transient relaxations of lower esophageal sphincter treatment of motor disorders |
| url | https://www.gastro-j.ru/jour/article/view/1507 |
| work_keys_str_mv | AT vtivashkin evolutionofconceptofesophagealmotordisturbancesinpathogenesisofgastroesophagealrefluxdisease AT astrukhmanov evolutionofconceptofesophagealmotordisturbancesinpathogenesisofgastroesophagealrefluxdisease |