Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients
Abstract Objectives Procalcitonin (PCT) is a critical diagnostic biomarker for bacterial infections in patients. Numerous studies have shown that PCT have high sensitivity and specificity for diagnosing bloodstream infection. However, the cut-off value of PCT for the diagnosis of bloodstream infecti...
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2025-02-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-024-10415-y |
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| author | Qi Sun Qingsong Lin Yanxia Lv Zhiying Tian Qiushuang Yan Yaqing Yu Xue Fu Hongjing Yao Fujun Sun Yonghui Xia Guoqing Zhu Sizhou Feng |
| author_facet | Qi Sun Qingsong Lin Yanxia Lv Zhiying Tian Qiushuang Yan Yaqing Yu Xue Fu Hongjing Yao Fujun Sun Yonghui Xia Guoqing Zhu Sizhou Feng |
| author_sort | Qi Sun |
| collection | DOAJ |
| description | Abstract Objectives Procalcitonin (PCT) is a critical diagnostic biomarker for bacterial infections in patients. Numerous studies have shown that PCT have high sensitivity and specificity for diagnosing bloodstream infection. However, the cut-off value of PCT for the diagnosis of bloodstream infections in patients with hematolgic diseases is still unclear and unreliable. Methods We conducted a retrospective study involving 2299 cases with hematological diseases and who had been performed blood culture and PCT test within 24 h. Results For patients with hematological diseases, the serum PCT was slightly elevated in the BSI group. We found that most hematological patients with bloodstream infection were in the stage of severe neutropenia. The main infected strains were Escherichia coli (n = 84, 21%), Klebsiella pneumoniae (n = 61, 15.25%) and Pseudomonas aeruginosa (n = 65, 16.25%), and the increasing trend of PCT level was more obvious in patients infected with Gram-negative bacteria. ROC analysis results showed that the area under the receiver operating characteristic curve for distinguishing bacterial infection from non-bacterial infection was 0.554 (95%CI: 0.522–0.585) with the diagnostic threshold of BSI (PCT > 0.5ng/mL). Conclusions In our study, low PCT levels were found in patients with hematological diseases, and a better cut-off value may be necessary to determine infection in hematology patients. |
| format | Article |
| id | doaj-art-b52d6055d268487292f24743faa0a501 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj-art-b52d6055d268487292f24743faa0a5012025-02-09T12:14:25ZengBMCBMC Infectious Diseases1471-23342025-02-0125111010.1186/s12879-024-10415-yPredictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patientsQi Sun0Qingsong Lin1Yanxia Lv2Zhiying Tian3Qiushuang Yan4Yaqing Yu5Xue Fu6Hongjing Yao7Fujun Sun8Yonghui Xia9Guoqing Zhu10Sizhou Feng11State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeState Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeAbstract Objectives Procalcitonin (PCT) is a critical diagnostic biomarker for bacterial infections in patients. Numerous studies have shown that PCT have high sensitivity and specificity for diagnosing bloodstream infection. However, the cut-off value of PCT for the diagnosis of bloodstream infections in patients with hematolgic diseases is still unclear and unreliable. Methods We conducted a retrospective study involving 2299 cases with hematological diseases and who had been performed blood culture and PCT test within 24 h. Results For patients with hematological diseases, the serum PCT was slightly elevated in the BSI group. We found that most hematological patients with bloodstream infection were in the stage of severe neutropenia. The main infected strains were Escherichia coli (n = 84, 21%), Klebsiella pneumoniae (n = 61, 15.25%) and Pseudomonas aeruginosa (n = 65, 16.25%), and the increasing trend of PCT level was more obvious in patients infected with Gram-negative bacteria. ROC analysis results showed that the area under the receiver operating characteristic curve for distinguishing bacterial infection from non-bacterial infection was 0.554 (95%CI: 0.522–0.585) with the diagnostic threshold of BSI (PCT > 0.5ng/mL). Conclusions In our study, low PCT levels were found in patients with hematological diseases, and a better cut-off value may be necessary to determine infection in hematology patients.https://doi.org/10.1186/s12879-024-10415-yProcalcitonin (PCT)Bloodstream infection (BSI)Hematology patientsCut-off level |
| spellingShingle | Qi Sun Qingsong Lin Yanxia Lv Zhiying Tian Qiushuang Yan Yaqing Yu Xue Fu Hongjing Yao Fujun Sun Yonghui Xia Guoqing Zhu Sizhou Feng Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients BMC Infectious Diseases Procalcitonin (PCT) Bloodstream infection (BSI) Hematology patients Cut-off level |
| title | Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients |
| title_full | Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients |
| title_fullStr | Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients |
| title_full_unstemmed | Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients |
| title_short | Predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients |
| title_sort | predictive value of serum procalcitonin level for the diagnosis of bloodstream infections in hematological patients |
| topic | Procalcitonin (PCT) Bloodstream infection (BSI) Hematology patients Cut-off level |
| url | https://doi.org/10.1186/s12879-024-10415-y |
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