Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model
BackgroundAlthough prosthetic conduits for coronary artery bypass grafting (CABG) are increasingly needed because of the limited availability and patency of autologous conduits, no alternatives have succeeded.MethodsSixteen sheep underwent CABG. Thirteen received a bioabsorbable polymer graft with a...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1488794/full |
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| author | Yu Sato Matthew Kutnya Biniyam Abebe Mohammed S. El Kurdi Martijn Cox Richard W. Bianco Bart Meuris Yoshinobu Onuma Patrick W. Serruys Renu Virmani |
| author_facet | Yu Sato Matthew Kutnya Biniyam Abebe Mohammed S. El Kurdi Martijn Cox Richard W. Bianco Bart Meuris Yoshinobu Onuma Patrick W. Serruys Renu Virmani |
| author_sort | Yu Sato |
| collection | DOAJ |
| description | BackgroundAlthough prosthetic conduits for coronary artery bypass grafting (CABG) are increasingly needed because of the limited availability and patency of autologous conduits, no alternatives have succeeded.MethodsSixteen sheep underwent CABG. Thirteen received a bioabsorbable polymer graft with an incorporated nitinol microskeleton (Xeltis coronary artery bypass graft [XABG]), and three received autologous saphenous vein grafts (SVG). Pathological evaluation was conducted at 12 months.ResultsIn the XABG group, two sheep died perioperatively; two were sacrificed at 3 months (1 occluded, 1 patent) and two at 6 months (both patent). Two more died from occlusion at 9–10 months, and five survived with patent grafts at 12 months. All SVGs remained patent for 12 months. Histology demonstrated near-complete luminal endothelialization in XABG, with increased polymer adsorption and matrix deposition. The cross-sectional area of the SVG lumen was significantly larger than XABGs (48.2 mm2 vs 12.9 mm2, p = 0.0018), consistent with a reduced angiographic flow velocity in SVG. The neointimal area was greater in SVGs than XABGs (19.6 vs. 6.7 mm2, p = 0.0005), especially at the distal ends of SVGs due to thrombus formation.ConclusionXABG demonstrated 1-year feasibility with consistent endothelialization and polymer absorption. While SVGs had better patency, they showed greater diametrical irregularity and subsequent neointimal proliferation. |
| format | Article |
| id | doaj-art-b62a9b2d65d744bd9be38426ae86d020 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-b62a9b2d65d744bd9be38426ae86d0202025-02-10T06:49:04ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.14887941488794Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine modelYu Sato0Matthew Kutnya1Biniyam Abebe2Mohammed S. El Kurdi3Martijn Cox4Richard W. Bianco5Bart Meuris6Yoshinobu Onuma7Patrick W. Serruys8Renu Virmani9CVPath Institute, Gaithersburg, MD, United StatesCVPath Institute, Gaithersburg, MD, United StatesCVPath Institute, Gaithersburg, MD, United StatesXeltis Eindhoven, Eindhoven, NetherlandsXeltis Eindhoven, Eindhoven, NetherlandsExperimental Surgical Services, University of Minneapolis, Minneapolis, MN, United StatesDepartment of Cardiac Surgery, University Hospital Leuven, Leuven, BelgiumDepartment of Cardiology, National University of Ireland, Galway (NUIG), Galway, IrelandDepartment of Cardiology, National University of Ireland, Galway (NUIG), Galway, IrelandCVPath Institute, Gaithersburg, MD, United StatesBackgroundAlthough prosthetic conduits for coronary artery bypass grafting (CABG) are increasingly needed because of the limited availability and patency of autologous conduits, no alternatives have succeeded.MethodsSixteen sheep underwent CABG. Thirteen received a bioabsorbable polymer graft with an incorporated nitinol microskeleton (Xeltis coronary artery bypass graft [XABG]), and three received autologous saphenous vein grafts (SVG). Pathological evaluation was conducted at 12 months.ResultsIn the XABG group, two sheep died perioperatively; two were sacrificed at 3 months (1 occluded, 1 patent) and two at 6 months (both patent). Two more died from occlusion at 9–10 months, and five survived with patent grafts at 12 months. All SVGs remained patent for 12 months. Histology demonstrated near-complete luminal endothelialization in XABG, with increased polymer adsorption and matrix deposition. The cross-sectional area of the SVG lumen was significantly larger than XABGs (48.2 mm2 vs 12.9 mm2, p = 0.0018), consistent with a reduced angiographic flow velocity in SVG. The neointimal area was greater in SVGs than XABGs (19.6 vs. 6.7 mm2, p = 0.0005), especially at the distal ends of SVGs due to thrombus formation.ConclusionXABG demonstrated 1-year feasibility with consistent endothelialization and polymer absorption. While SVGs had better patency, they showed greater diametrical irregularity and subsequent neointimal proliferation.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1488794/fullcoronary artery diseasecoronary artery bypass graftingsaphenous vein graftsmall diameter vascular grafttissue-engineered vascular graftlarge animal model |
| spellingShingle | Yu Sato Matthew Kutnya Biniyam Abebe Mohammed S. El Kurdi Martijn Cox Richard W. Bianco Bart Meuris Yoshinobu Onuma Patrick W. Serruys Renu Virmani Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model Frontiers in Bioengineering and Biotechnology coronary artery disease coronary artery bypass grafting saphenous vein graft small diameter vascular graft tissue-engineered vascular graft large animal model |
| title | Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model |
| title_full | Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model |
| title_fullStr | Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model |
| title_full_unstemmed | Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model |
| title_short | Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model |
| title_sort | histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model |
| topic | coronary artery disease coronary artery bypass grafting saphenous vein graft small diameter vascular graft tissue-engineered vascular graft large animal model |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1488794/full |
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