Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting
Abstract Intravascular surgical instruments require precise navigation within narrow vessels, necessitating maximum flexibility, minimal diameter, and high degrees of freedom. Existing tools often lack control during insertion due to undesirable bending, limiting vessel accessibility and risking tis...
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| Format: | Article |
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Nature Portfolio
2024-05-01
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| Series: | Communications Engineering |
| Online Access: | https://doi.org/10.1038/s44172-024-00215-2 |
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| author | Leendert-Jan W. Ligtenberg Nicole C. A. Rabou Constantinos Goulas Wytze C. Duinmeijer Frank R. Halfwerk Jutta Arens Roger Lomme Veronika Magdanz Anke Klingner Emily A. M. Klein Rot Colin H. E. Nijland Dorothee Wasserberg H. Remco Liefers Pascal Jonkheijm Arturo Susarrey-Arce Michiel Warlé Islam S. M. Khalil |
| author_facet | Leendert-Jan W. Ligtenberg Nicole C. A. Rabou Constantinos Goulas Wytze C. Duinmeijer Frank R. Halfwerk Jutta Arens Roger Lomme Veronika Magdanz Anke Klingner Emily A. M. Klein Rot Colin H. E. Nijland Dorothee Wasserberg H. Remco Liefers Pascal Jonkheijm Arturo Susarrey-Arce Michiel Warlé Islam S. M. Khalil |
| author_sort | Leendert-Jan W. Ligtenberg |
| collection | DOAJ |
| description | Abstract Intravascular surgical instruments require precise navigation within narrow vessels, necessitating maximum flexibility, minimal diameter, and high degrees of freedom. Existing tools often lack control during insertion due to undesirable bending, limiting vessel accessibility and risking tissue damage. Next-generation instruments aim to develop hemocompatible untethered devices controlled by external magnetic forces. Achieving this goal remains complex due to testing and implementation challenges in clinical environments. Here we assess the operational effectiveness of hemocompatible untethered magnetic robots using an ex vivo porcine aorta model. The results demonstrate a linear decrease in the swimming speed of untethered magnetic robots as arterial blood flow increases, with the capability to navigate against a maximum arterial flow rate of 67 mL/min. The untethered magnetic robots effectively demonstrate locomotion in a difficult-to-access target site, navigating through the abdominal aorta and reaching the distal end of the renal artery. |
| format | Article |
| id | doaj-art-b6b9cb6c9e7e4a78a29bec813faa03e8 |
| institution | Kabale University |
| issn | 2731-3395 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Engineering |
| spelling | doaj-art-b6b9cb6c9e7e4a78a29bec813faa03e82025-02-09T12:39:20ZengNature PortfolioCommunications Engineering2731-33952024-05-013111510.1038/s44172-024-00215-2Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical settingLeendert-Jan W. Ligtenberg0Nicole C. A. Rabou1Constantinos Goulas2Wytze C. Duinmeijer3Frank R. Halfwerk4Jutta Arens5Roger Lomme6Veronika Magdanz7Anke Klingner8Emily A. M. Klein Rot9Colin H. E. Nijland10Dorothee Wasserberg11H. Remco Liefers12Pascal Jonkheijm13Arturo Susarrey-Arce14Michiel Warlé15Islam S. M. Khalil16Department of Biomechanical Engineering, University of TwenteDepartment of Biomechanical Engineering, University of TwenteDepartment of Design Production and Management, University of TwenteDepartment of Biomechanical Engineering, University of TwenteDepartment of Biomechanical Engineering, University of TwenteDepartment of Biomechanical Engineering, University of TwenteRadboud University Medical CenterDepartment of System Design Engineering, University of WaterlooDepartment of Physics, German University in CairoLipoCoat B.V.LipoCoat B.V.LipoCoat B.V.Technical Medical Centre, University of TwenteLipoCoat B.V.Mesoscale Chemical Systems, MESA+ Institute, University of TwenteDepartment of Surgery, Division of Vascular and Transplant Surgery, Radboud University Medical Center NijmegenDepartment of Biomechanical Engineering, University of TwenteAbstract Intravascular surgical instruments require precise navigation within narrow vessels, necessitating maximum flexibility, minimal diameter, and high degrees of freedom. Existing tools often lack control during insertion due to undesirable bending, limiting vessel accessibility and risking tissue damage. Next-generation instruments aim to develop hemocompatible untethered devices controlled by external magnetic forces. Achieving this goal remains complex due to testing and implementation challenges in clinical environments. Here we assess the operational effectiveness of hemocompatible untethered magnetic robots using an ex vivo porcine aorta model. The results demonstrate a linear decrease in the swimming speed of untethered magnetic robots as arterial blood flow increases, with the capability to navigate against a maximum arterial flow rate of 67 mL/min. The untethered magnetic robots effectively demonstrate locomotion in a difficult-to-access target site, navigating through the abdominal aorta and reaching the distal end of the renal artery.https://doi.org/10.1038/s44172-024-00215-2 |
| spellingShingle | Leendert-Jan W. Ligtenberg Nicole C. A. Rabou Constantinos Goulas Wytze C. Duinmeijer Frank R. Halfwerk Jutta Arens Roger Lomme Veronika Magdanz Anke Klingner Emily A. M. Klein Rot Colin H. E. Nijland Dorothee Wasserberg H. Remco Liefers Pascal Jonkheijm Arturo Susarrey-Arce Michiel Warlé Islam S. M. Khalil Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting Communications Engineering |
| title | Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting |
| title_full | Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting |
| title_fullStr | Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting |
| title_full_unstemmed | Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting |
| title_short | Ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting |
| title_sort | ex vivo validation of magnetically actuated intravascular untethered robots in a clinical setting |
| url | https://doi.org/10.1038/s44172-024-00215-2 |
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