Role of HNF6 in liver homeostasis and pathophysiology
Abstract Background Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly ex...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Molecular Medicine |
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| Online Access: | https://doi.org/10.1186/s10020-025-01105-9 |
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| author | Miaomiao Tian Weizhen Gao Shujun Ma Huiling Cao Yu Zhang Fuxiang An Jianni Qi Zhen Yang |
| author_facet | Miaomiao Tian Weizhen Gao Shujun Ma Huiling Cao Yu Zhang Fuxiang An Jianni Qi Zhen Yang |
| author_sort | Miaomiao Tian |
| collection | DOAJ |
| description | Abstract Background Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly expressed as an HNF in the liver. Main body HNF6 regulates not only the formation of the liver but also the proliferation and differentiation of hepatocytes. Additionally, HNF6 controls the migration and adhesion of hepatocellular carcinoma cells and plays a significant role in liver metabolism. Its expression is affected by epigenetic modifications such as DNA methylation, post-translational modifications, and microRNAs. Recently, HNF6 was also found to be expressed in tissues, such as the pancreas, intestine, and lungs, where it controls their formation by regulating cell differentiation and influences their pathophysiological processes via various mechanisms. Conclusion In this review, we highlight advances in HNF6-related research concerning liver diseases and provide a summary of its potential mechanisms of action as a transcription factor in regulating downstream genes and epigenetic modifications. We also highlight gaps in liver disease research and provide future research directions for the application of HNF6 and its downstream molecules as attractive targets in the treatment of liver diseases. |
| format | Article |
| id | doaj-art-b7b18c0f7ca84c6d86bb4bd8a7f3bb7c |
| institution | Kabale University |
| issn | 1528-3658 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Medicine |
| spelling | doaj-art-b7b18c0f7ca84c6d86bb4bd8a7f3bb7c2025-02-09T12:42:11ZengBMCMolecular Medicine1528-36582025-02-0131111310.1186/s10020-025-01105-9Role of HNF6 in liver homeostasis and pathophysiologyMiaomiao Tian0Weizhen Gao1Shujun Ma2Huiling Cao3Yu Zhang4Fuxiang An5Jianni Qi6Zhen Yang7Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityShandong Provincial Hospital Affiliated to Shandong First Medical UniversityAbstract Background Hepatocyte nuclear factor 6 (HNF6), a member of the HNF family, contains single cleft and homologous domains, which form a DNA-binding region that targets the promoter regions of genes that bind to liver-specific genes and regulate their expression. Furthermore, HNF6 is highly expressed as an HNF in the liver. Main body HNF6 regulates not only the formation of the liver but also the proliferation and differentiation of hepatocytes. Additionally, HNF6 controls the migration and adhesion of hepatocellular carcinoma cells and plays a significant role in liver metabolism. Its expression is affected by epigenetic modifications such as DNA methylation, post-translational modifications, and microRNAs. Recently, HNF6 was also found to be expressed in tissues, such as the pancreas, intestine, and lungs, where it controls their formation by regulating cell differentiation and influences their pathophysiological processes via various mechanisms. Conclusion In this review, we highlight advances in HNF6-related research concerning liver diseases and provide a summary of its potential mechanisms of action as a transcription factor in regulating downstream genes and epigenetic modifications. We also highlight gaps in liver disease research and provide future research directions for the application of HNF6 and its downstream molecules as attractive targets in the treatment of liver diseases.https://doi.org/10.1186/s10020-025-01105-9HNF6Epigenetic modificationsMetabolismLiver pathophysiologyTranscription factor |
| spellingShingle | Miaomiao Tian Weizhen Gao Shujun Ma Huiling Cao Yu Zhang Fuxiang An Jianni Qi Zhen Yang Role of HNF6 in liver homeostasis and pathophysiology Molecular Medicine HNF6 Epigenetic modifications Metabolism Liver pathophysiology Transcription factor |
| title | Role of HNF6 in liver homeostasis and pathophysiology |
| title_full | Role of HNF6 in liver homeostasis and pathophysiology |
| title_fullStr | Role of HNF6 in liver homeostasis and pathophysiology |
| title_full_unstemmed | Role of HNF6 in liver homeostasis and pathophysiology |
| title_short | Role of HNF6 in liver homeostasis and pathophysiology |
| title_sort | role of hnf6 in liver homeostasis and pathophysiology |
| topic | HNF6 Epigenetic modifications Metabolism Liver pathophysiology Transcription factor |
| url | https://doi.org/10.1186/s10020-025-01105-9 |
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