Modern concept of bacterial complications at liver cirrhosis
The aim of review. To carry over for consideration the basic mechanisms of bacterial infections at liver cirrhosis (LC), their consequences, methods of diagnostics and prophylaxis.Original positions. Bacterial infections is a cause of high mortality in liver cirrhosis patients. These patients are mo...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-12-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1575 |
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| author | M. S. Zharkova M. V. Mayevskaya V. T. Ivashkin |
| author_facet | M. S. Zharkova M. V. Mayevskaya V. T. Ivashkin |
| author_sort | M. S. Zharkova |
| collection | DOAJ |
| description | The aim of review. To carry over for consideration the basic mechanisms of bacterial infections at liver cirrhosis (LC), their consequences, methods of diagnostics and prophylaxis.Original positions. Bacterial infections is a cause of high mortality in liver cirrhosis patients. These patients are more predisposed to infections than others hospital patients due to disorders of immune system along with bacterial translocation from intestine, that, in turn, depends on immune changes of the latter and bacterial overgrowth. Bacterial translocation even without clinical signs of infection results in deterioration of hemodynamic status at patients with liver function decompensation that causes progression of portal hypertension and hepatorenal syndrome. Proinflammatory response related to bacterial complication stimulates progression of liver failure, encephalopathy, disorders in blood coagulation system, thus triggering gastro-intestinal bleeding.Conclusion. Bacterial infections is the important cause of morbidity and mortality in patients with LC that is caused, first of all, by immune-compromised state. Prophylaxis, early diagnostics and well-timed treatment of infections considerably increase survival rate of these patients. Various methods of prophylaxis, including the use of antibiotics, pre- and probiotics, bile acids can be applied to alter bacterial overgrowth and bacterial translocation. Each of these methods proved its efficacy in scientific studies. |
| format | Article |
| id | doaj-art-b93dc13660444defaade8e1987e269ed |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-12-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-b93dc13660444defaade8e1987e269ed2025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-12-0120661691080Modern concept of bacterial complications at liver cirrhosisM. S. ZharkovaM. V. MayevskayaV. T. IvashkinThe aim of review. To carry over for consideration the basic mechanisms of bacterial infections at liver cirrhosis (LC), their consequences, methods of diagnostics and prophylaxis.Original positions. Bacterial infections is a cause of high mortality in liver cirrhosis patients. These patients are more predisposed to infections than others hospital patients due to disorders of immune system along with bacterial translocation from intestine, that, in turn, depends on immune changes of the latter and bacterial overgrowth. Bacterial translocation even without clinical signs of infection results in deterioration of hemodynamic status at patients with liver function decompensation that causes progression of portal hypertension and hepatorenal syndrome. Proinflammatory response related to bacterial complication stimulates progression of liver failure, encephalopathy, disorders in blood coagulation system, thus triggering gastro-intestinal bleeding.Conclusion. Bacterial infections is the important cause of morbidity and mortality in patients with LC that is caused, first of all, by immune-compromised state. Prophylaxis, early diagnostics and well-timed treatment of infections considerably increase survival rate of these patients. Various methods of prophylaxis, including the use of antibiotics, pre- and probiotics, bile acids can be applied to alter bacterial overgrowth and bacterial translocation. Each of these methods proved its efficacy in scientific studies.https://www.gastro-j.ru/jour/article/view/1575bacterial infectionsliver cirrhosisbacterial translocationbacterial overgrowthpermeability of intestinal wallhyperdynamic type of circulation |
| spellingShingle | M. S. Zharkova M. V. Mayevskaya V. T. Ivashkin Modern concept of bacterial complications at liver cirrhosis Российский журнал гастроэнтерологии, гепатологии, колопроктологии bacterial infections liver cirrhosis bacterial translocation bacterial overgrowth permeability of intestinal wall hyperdynamic type of circulation |
| title | Modern concept of bacterial complications at liver cirrhosis |
| title_full | Modern concept of bacterial complications at liver cirrhosis |
| title_fullStr | Modern concept of bacterial complications at liver cirrhosis |
| title_full_unstemmed | Modern concept of bacterial complications at liver cirrhosis |
| title_short | Modern concept of bacterial complications at liver cirrhosis |
| title_sort | modern concept of bacterial complications at liver cirrhosis |
| topic | bacterial infections liver cirrhosis bacterial translocation bacterial overgrowth permeability of intestinal wall hyperdynamic type of circulation |
| url | https://www.gastro-j.ru/jour/article/view/1575 |
| work_keys_str_mv | AT mszharkova modernconceptofbacterialcomplicationsatlivercirrhosis AT mvmayevskaya modernconceptofbacterialcomplicationsatlivercirrhosis AT vtivashkin modernconceptofbacterialcomplicationsatlivercirrhosis |