The role of lipids in promoting hair growth through HIF-1 signaling pathway
Abstract Understanding the underlying mechanisms regulating hair regeneration is crucial, especially given the increasing demand for effective drugs to treat hair loss, which remain not fully elucidated. In the present study, we found that lipid metabolism was attenuated in the scalp tissues of pati...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-88697-8 |
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| author | Jieun Seo Kotone Matsumoto Ayaka Nanmo Shan Tu Do-Won Jeong Yang-Sook Chun Lei Yan Tatsuto Kageyama Junji Fukuda |
| author_facet | Jieun Seo Kotone Matsumoto Ayaka Nanmo Shan Tu Do-Won Jeong Yang-Sook Chun Lei Yan Tatsuto Kageyama Junji Fukuda |
| author_sort | Jieun Seo |
| collection | DOAJ |
| description | Abstract Understanding the underlying mechanisms regulating hair regeneration is crucial, especially given the increasing demand for effective drugs to treat hair loss, which remain not fully elucidated. In the present study, we found that lipid metabolism was attenuated in the scalp tissues of patients with androgenetic alopecia. Lipid supplementation in the culture medium upregulated hair growth-related genes and promoted the proliferation of human dermal papilla cells (DPCs). By using RNA-sequencing analysis and HIF-1α knockdown in DPCs, we found that HIF-1α is a potential candidate that governs lipid-reinforced upregulation of trichogenic genes. Finally, we assessed the hair growth-promoting effects of lipids using in vitro hair follicle organoids and found that lipids accelerated the elongation of hair-shaft-like structures. Our results highlight the importance of lipids in promoting hair growth through HIF-1 signaling, suggesting that this may be a promising target for the treatment of hair loss. |
| format | Article |
| id | doaj-art-ba3de585429c4adf8376155f7b4ac595 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-ba3de585429c4adf8376155f7b4ac5952025-02-09T12:34:02ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-88697-8The role of lipids in promoting hair growth through HIF-1 signaling pathwayJieun Seo0Kotone Matsumoto1Ayaka Nanmo2Shan Tu3Do-Won Jeong4Yang-Sook Chun5Lei Yan6Tatsuto Kageyama7Junji Fukuda8Faculty of Engineering, Yokohama National UniversityFaculty of Engineering, Yokohama National UniversityFaculty of Engineering, Yokohama National UniversityFaculty of Engineering, Yokohama National UniversityDepartment of Cell Biology, Harvard Medical SchoolDepartment of Biomedical Sciences, Seoul National University College of MedicineFaculty of Engineering, Yokohama National UniversityFaculty of Engineering, Yokohama National UniversityFaculty of Engineering, Yokohama National UniversityAbstract Understanding the underlying mechanisms regulating hair regeneration is crucial, especially given the increasing demand for effective drugs to treat hair loss, which remain not fully elucidated. In the present study, we found that lipid metabolism was attenuated in the scalp tissues of patients with androgenetic alopecia. Lipid supplementation in the culture medium upregulated hair growth-related genes and promoted the proliferation of human dermal papilla cells (DPCs). By using RNA-sequencing analysis and HIF-1α knockdown in DPCs, we found that HIF-1α is a potential candidate that governs lipid-reinforced upregulation of trichogenic genes. Finally, we assessed the hair growth-promoting effects of lipids using in vitro hair follicle organoids and found that lipids accelerated the elongation of hair-shaft-like structures. Our results highlight the importance of lipids in promoting hair growth through HIF-1 signaling, suggesting that this may be a promising target for the treatment of hair loss.https://doi.org/10.1038/s41598-025-88697-8Hair growthLipidsHIF-1αDermal papilla cellsHair follicle organoids |
| spellingShingle | Jieun Seo Kotone Matsumoto Ayaka Nanmo Shan Tu Do-Won Jeong Yang-Sook Chun Lei Yan Tatsuto Kageyama Junji Fukuda The role of lipids in promoting hair growth through HIF-1 signaling pathway Scientific Reports Hair growth Lipids HIF-1α Dermal papilla cells Hair follicle organoids |
| title | The role of lipids in promoting hair growth through HIF-1 signaling pathway |
| title_full | The role of lipids in promoting hair growth through HIF-1 signaling pathway |
| title_fullStr | The role of lipids in promoting hair growth through HIF-1 signaling pathway |
| title_full_unstemmed | The role of lipids in promoting hair growth through HIF-1 signaling pathway |
| title_short | The role of lipids in promoting hair growth through HIF-1 signaling pathway |
| title_sort | role of lipids in promoting hair growth through hif 1 signaling pathway |
| topic | Hair growth Lipids HIF-1α Dermal papilla cells Hair follicle organoids |
| url | https://doi.org/10.1038/s41598-025-88697-8 |
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