Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study
Background: Acanthosis nigricans (AN) is a common finding often associated with hyperinsulinemia and childhood obesity. There has been a lack of studies evaluating the association of AN with underlying cardio-metabolic risk factors in children and adolescents. Our objective was to study the associat...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Journal of Family Medicine and Primary Care |
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| Online Access: | https://journals.lww.com/10.4103/jfmpc.jfmpc_866_24 |
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| author | Rashmi R. Das Manaswini Mangaraj Saurav Nayak Amit K. Satapathy Samarendra Mahapatro |
| author_facet | Rashmi R. Das Manaswini Mangaraj Saurav Nayak Amit K. Satapathy Samarendra Mahapatro |
| author_sort | Rashmi R. Das |
| collection | DOAJ |
| description | Background:
Acanthosis nigricans (AN) is a common finding often associated with hyperinsulinemia and childhood obesity. There has been a lack of studies evaluating the association of AN with underlying cardio-metabolic risk factors in children and adolescents. Our objective was to study the association between AN and cardio-metabolic risk factors in children with overweight/obesity.
Methods:
This cross-sectional study included school-going children (6–16 years of age) with overweight/obesity. Physical examination, anthropometry, and blood pressure (BP) data were collected. Fasting blood samples were collected to measure insulin, glucose, homeostasis model assessment index (HOMAIR), and lipid profile.
Results:
Of 1930 children screened, 545 had overweight/obesity, and were included. Boys to girls ratio was 1.27. AN was present in 46.4% of children. Children with AN had higher body mass index [BMI] (P < 0.01), waist circumference [WC] (P < 0.01), systolic (P = 0.03), and diastolic BP (P = 0.02), hyperglycemia (P = 0.02), hyperinsulinemia (P < 0.01), and a higher HOMA-IR (P < 0.01) compared to those without AN. HDL level was lower in children with AN.
Conclusions:
Children with overweight/obesity who have AN have significant elevations of BP, insulin level, and HOMA-IR. AN is a clinical marker that seems to be associated with cardio-metabolic risk factors in children with overweight/obesity in the given study population. |
| format | Article |
| id | doaj-art-bb6543a36e9240139cbe1f2a72e13764 |
| institution | Kabale University |
| issn | 2249-4863 2278-7135 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Family Medicine and Primary Care |
| spelling | doaj-art-bb6543a36e9240139cbe1f2a72e137642025-02-11T12:59:29ZengWolters Kluwer Medknow PublicationsJournal of Family Medicine and Primary Care2249-48632278-71352025-01-0114125425810.4103/jfmpc.jfmpc_866_24Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional studyRashmi R. DasManaswini MangarajSaurav NayakAmit K. SatapathySamarendra MahapatroBackground: Acanthosis nigricans (AN) is a common finding often associated with hyperinsulinemia and childhood obesity. There has been a lack of studies evaluating the association of AN with underlying cardio-metabolic risk factors in children and adolescents. Our objective was to study the association between AN and cardio-metabolic risk factors in children with overweight/obesity. Methods: This cross-sectional study included school-going children (6–16 years of age) with overweight/obesity. Physical examination, anthropometry, and blood pressure (BP) data were collected. Fasting blood samples were collected to measure insulin, glucose, homeostasis model assessment index (HOMAIR), and lipid profile. Results: Of 1930 children screened, 545 had overweight/obesity, and were included. Boys to girls ratio was 1.27. AN was present in 46.4% of children. Children with AN had higher body mass index [BMI] (P < 0.01), waist circumference [WC] (P < 0.01), systolic (P = 0.03), and diastolic BP (P = 0.02), hyperglycemia (P = 0.02), hyperinsulinemia (P < 0.01), and a higher HOMA-IR (P < 0.01) compared to those without AN. HDL level was lower in children with AN. Conclusions: Children with overweight/obesity who have AN have significant elevations of BP, insulin level, and HOMA-IR. AN is a clinical marker that seems to be associated with cardio-metabolic risk factors in children with overweight/obesity in the given study population.https://journals.lww.com/10.4103/jfmpc.jfmpc_866_24body mass indexhoma-irinsulin resistancemetabolic syndrome |
| spellingShingle | Rashmi R. Das Manaswini Mangaraj Saurav Nayak Amit K. Satapathy Samarendra Mahapatro Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study Journal of Family Medicine and Primary Care body mass index homa-ir insulin resistance metabolic syndrome |
| title | Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study |
| title_full | Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study |
| title_fullStr | Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study |
| title_full_unstemmed | Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study |
| title_short | Acanthosis nigricans and its association with cardio-metabolic risk factors in children with overweight/obesity: A school-based cross-sectional study |
| title_sort | acanthosis nigricans and its association with cardio metabolic risk factors in children with overweight obesity a school based cross sectional study |
| topic | body mass index homa-ir insulin resistance metabolic syndrome |
| url | https://journals.lww.com/10.4103/jfmpc.jfmpc_866_24 |
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