Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations
Abstract Background Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake...
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BMC
2025-02-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-025-02930-5 |
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| author | Shuo Ding Juan Chen Yanchao Wu Huiru Lin Qiqiang Liang Gaoqin Teng Zhenjie Liu Man Huang |
| author_facet | Shuo Ding Juan Chen Yanchao Wu Huiru Lin Qiqiang Liang Gaoqin Teng Zhenjie Liu Man Huang |
| author_sort | Shuo Ding |
| collection | DOAJ |
| description | Abstract Background Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations. Methods Ten healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups. Vital signs and blood indices were meticulously monitored. The integrity of heparin coatings and thrombosis in the ECMO system were assessed at indicated time points, followed by histopathological analysis. Results All ten sheep survived to their planned endpoints under awake ECMO, exhibiting stable vital signs without notable reductions in blood cells. With the support of ECMO, all sheep demonstrated a significant increase in partial pressure of oxygen (PO2) and maintained oxygen saturation (SO2) between 99.8 and 100%. The heparin coating remained relatively intact even after prolonged ECMO operation. Anatomical observations and pathological histology analyses of major organs revealed no apparent abnormalities. Conclusions In healthy Hu sheep models with different maintenance periods, the novel ECMO support in awake state demonstrated high safety and feasibility. |
| format | Article |
| id | doaj-art-bb997cee84f7490680b5d83bc09e41be |
| institution | Kabale University |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj-art-bb997cee84f7490680b5d83bc09e41be2025-02-09T12:52:03ZengBMCBMC Anesthesiology1471-22532025-02-0125111210.1186/s12871-025-02930-5Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durationsShuo Ding0Juan Chen1Yanchao Wu2Huiru Lin3Qiqiang Liang4Gaoqin Teng5Zhenjie Liu6Man Huang7Department of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineDepartment of Vascular Surgery, The Second Affiliated Hospital of Zhejiang University School of MedicineDepartment of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang, University School of MedicineAbstract Background Extracorporeal membrane oxygenation (ECMO) provides effective support for respiratory and circulatory functions and stands as an essential means in the management of life-threatening conditions. This study aimed to evaluate the safety and efficacy of a novel ECMO system in awake sheep models across various support durations. Methods Ten healthy Hu sheep were divided into venovenous (VV) and venoarterial (VA) groups, further categorized into short, medium, and long-term observation subgroups. Vital signs and blood indices were meticulously monitored. The integrity of heparin coatings and thrombosis in the ECMO system were assessed at indicated time points, followed by histopathological analysis. Results All ten sheep survived to their planned endpoints under awake ECMO, exhibiting stable vital signs without notable reductions in blood cells. With the support of ECMO, all sheep demonstrated a significant increase in partial pressure of oxygen (PO2) and maintained oxygen saturation (SO2) between 99.8 and 100%. The heparin coating remained relatively intact even after prolonged ECMO operation. Anatomical observations and pathological histology analyses of major organs revealed no apparent abnormalities. Conclusions In healthy Hu sheep models with different maintenance periods, the novel ECMO support in awake state demonstrated high safety and feasibility.https://doi.org/10.1186/s12871-025-02930-5Extracorporeal membrane oxygenationECMOAwake ECMOOvine modelCardiopulmonary supportPreclinical evaluation |
| spellingShingle | Shuo Ding Juan Chen Yanchao Wu Huiru Lin Qiqiang Liang Gaoqin Teng Zhenjie Liu Man Huang Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations BMC Anesthesiology Extracorporeal membrane oxygenation ECMO Awake ECMO Ovine model Cardiopulmonary support Preclinical evaluation |
| title | Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations |
| title_full | Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations |
| title_fullStr | Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations |
| title_full_unstemmed | Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations |
| title_short | Application of a novel extracorporeal membrane oxygenation system in awake Hu sheep under various durations |
| title_sort | application of a novel extracorporeal membrane oxygenation system in awake hu sheep under various durations |
| topic | Extracorporeal membrane oxygenation ECMO Awake ECMO Ovine model Cardiopulmonary support Preclinical evaluation |
| url | https://doi.org/10.1186/s12871-025-02930-5 |
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