Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model.

Trichostatin A suppresses hearing loss by reducing oxidative stress and inflammation in an Alport syndrome model.

Alport syndrome (AS) is a genetic disorder marked by mutations in type IV collagen, leading to kidney glomerular dysfunction. AS also involves the cochlea, causing late-onset progressive hearing loss. Currently, there are no therapeutic drugs to protect hearing from AS. HDAC inhibitors (HDACis) are...

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Bibliographic Details
Main Authors: Yoon Seok Nam, Eun-Ji Gi, Yoo-Seung Ko, Sungsu Lee, Hyong-Ho Cho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0316033
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