Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis
Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by synovial inflammation, cartilage loss. Often manifesting as joint pain and limited mobility, it severely affects the quality of life of patients. Traditional treatment methods such as pharmacological injections and...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Medical Journal of Peking Union Medical College Hospital
2025-01-01
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| Series: | Xiehe Yixue Zazhi |
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| Online Access: | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-1049 |
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| author | GONG Jin ZHANG Jinjin CHEN Lili WANG Hui XING Yanchao |
| author_facet | GONG Jin ZHANG Jinjin CHEN Lili WANG Hui XING Yanchao |
| author_sort | GONG Jin |
| collection | DOAJ |
| description | Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by synovial inflammation, cartilage loss. Often manifesting as joint pain and limited mobility, it severely affects the quality of life of patients. Traditional treatment methods such as pharmacological injections and surgical interventions primarily aim to alleviate symptoms but have limited effects on cartilage repair. Human umbilical cord mesenchymal stem cells (hUC-MSCs), due to their anti-inflammatory and chondrogenic capabilities, is considered a new hope for the treatment of KOA. This article synthesizes the latest research findings from both domestic and international sources to discuss the theoretical basis for the clinical application of hUC-MSCs in treating KOA, clinical study design, and efficacy evaluation. It also addresses the challenges in the clinical application of hUC-MSCs and explores future directions, in the hope of providing feasible theoretical support for the treatment of KOA with hUC-MSCs. |
| format | Article |
| id | doaj-art-bc678b5cd0504d4586c54453c2b7c86c |
| institution | Kabale University |
| issn | 1674-9081 |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Editorial Office of Medical Journal of Peking Union Medical College Hospital |
| record_format | Article |
| series | Xiehe Yixue Zazhi |
| spelling | doaj-art-bc678b5cd0504d4586c54453c2b7c86c2025-02-08T07:47:34ZzhoEditorial Office of Medical Journal of Peking Union Medical College HospitalXiehe Yixue Zazhi1674-90812025-01-01161758210.12290/xhyxzz.2024-1049Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee OsteoarthritisGONG JinZHANG JinjinCHEN Lili0WANG HuiXING YanchaoDepartment of Blood Transfusion, General Hospital of Xinjiang Military Command, Urumqi 830099, ChinaKnee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by synovial inflammation, cartilage loss. Often manifesting as joint pain and limited mobility, it severely affects the quality of life of patients. Traditional treatment methods such as pharmacological injections and surgical interventions primarily aim to alleviate symptoms but have limited effects on cartilage repair. Human umbilical cord mesenchymal stem cells (hUC-MSCs), due to their anti-inflammatory and chondrogenic capabilities, is considered a new hope for the treatment of KOA. This article synthesizes the latest research findings from both domestic and international sources to discuss the theoretical basis for the clinical application of hUC-MSCs in treating KOA, clinical study design, and efficacy evaluation. It also addresses the challenges in the clinical application of hUC-MSCs and explores future directions, in the hope of providing feasible theoretical support for the treatment of KOA with hUC-MSCs.https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-1049human umbilical cord mesenchymal stem cellsknee osteoarthritiscartilage regeneration |
| spellingShingle | GONG Jin ZHANG Jinjin CHEN Lili WANG Hui XING Yanchao Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis Xiehe Yixue Zazhi human umbilical cord mesenchymal stem cells knee osteoarthritis cartilage regeneration |
| title | Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis |
| title_full | Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis |
| title_fullStr | Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis |
| title_full_unstemmed | Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis |
| title_short | Research Progress on Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Knee Osteoarthritis |
| title_sort | research progress on human umbilical cord mesenchymal stem cells in the treatment of knee osteoarthritis |
| topic | human umbilical cord mesenchymal stem cells knee osteoarthritis cartilage regeneration |
| url | https://xhyxzz.pumch.cn/article/doi/10.12290/xhyxzz.2024-1049 |
| work_keys_str_mv | AT gongjin researchprogressonhumanumbilicalcordmesenchymalstemcellsinthetreatmentofkneeosteoarthritis AT zhangjinjin researchprogressonhumanumbilicalcordmesenchymalstemcellsinthetreatmentofkneeosteoarthritis AT chenlili researchprogressonhumanumbilicalcordmesenchymalstemcellsinthetreatmentofkneeosteoarthritis AT wanghui researchprogressonhumanumbilicalcordmesenchymalstemcellsinthetreatmentofkneeosteoarthritis AT xingyanchao researchprogressonhumanumbilicalcordmesenchymalstemcellsinthetreatmentofkneeosteoarthritis |