Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy
Objective: This retrospective study aimed at comparing the extent of epithelialization in mastoid obliteration after Canal Wall Down (CWD) mastoidectomy using Hydroxyapatite (HA) alone or using HA in combination with Concentrated Growth Factor (CGF) extracted from autologous blood. Methods: A total...
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Elsevier
2025-05-01
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| Series: | Brazilian Journal of Otorhinolaryngology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869425000047 |
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| author | Mengyi Liu Lue Zhang Quanming Zhang Nan Zeng Shuo Li Shuyue Guo Yaqin Zhao Mingxing Tang Qiong Yang |
| author_facet | Mengyi Liu Lue Zhang Quanming Zhang Nan Zeng Shuo Li Shuyue Guo Yaqin Zhao Mingxing Tang Qiong Yang |
| author_sort | Mengyi Liu |
| collection | DOAJ |
| description | Objective: This retrospective study aimed at comparing the extent of epithelialization in mastoid obliteration after Canal Wall Down (CWD) mastoidectomy using Hydroxyapatite (HA) alone or using HA in combination with Concentrated Growth Factor (CGF) extracted from autologous blood. Methods: A total of 56 patients undergoing the CWD mastoidectomy were enrolled. One group was treated by HA, while the other group received HA and CGF for mastoid obliteration (CGF/HA). A review of the medical follow-up records of all patients was conducted, with a primary focus on the otoendoscopic imaging materials. Complete epithelialization was determined by the absence of granulation, discharge, and swelling. The requisite period for complete epithelialization of the mastoid cavity was thus calculated, scored, and analyzed between treatments. Results: Ear discharge, graft swelling, and poor blood supply were more frequently observed in the HA group. The proportion of patients group that achieved complete epithelialization within 60 days post operation was significantly higher in the CGF/HA group than the HA group. According to the scoring system for complete epithelialization, the median score of the CGF/HA group was 2, significantly higher than that of the HA treatment group (median score = 1, p = 0.032). Altogether, our results indicated that duration needed for complete epithelialization in the CGF/HA group was shorter than the control group. Conclusion: The application of CGF to surgical cavity obliteration following a CWD mastoidectomy significantly promotes epithelialization, thereby achieving satisfactory results. Randomized controlled trials with a larger number of patients enrolled were worth launching in the future to better substantiate the value of CGF in obliteration of mastoid cavity. Level of evidence: Level 2-Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence. |
| format | Article |
| id | doaj-art-bcc8a5d059d041a9a20e557aac89ea9d |
| institution | Kabale University |
| issn | 1808-8694 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj-art-bcc8a5d059d041a9a20e557aac89ea9d2025-02-07T04:47:22ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942025-05-01913101561Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomyMengyi Liu0Lue Zhang1Quanming Zhang2Nan Zeng3Shuo Li4Shuyue Guo5Yaqin Zhao6Mingxing Tang7Qiong Yang8Shenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaShenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaShenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaShenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaShenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaShenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaShenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaCorresponding authors.; Shenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaCorresponding authors.; Shenzhen Nanshan People’s Hospital, Department of Otolaryngology, Shenzhen, ChinaObjective: This retrospective study aimed at comparing the extent of epithelialization in mastoid obliteration after Canal Wall Down (CWD) mastoidectomy using Hydroxyapatite (HA) alone or using HA in combination with Concentrated Growth Factor (CGF) extracted from autologous blood. Methods: A total of 56 patients undergoing the CWD mastoidectomy were enrolled. One group was treated by HA, while the other group received HA and CGF for mastoid obliteration (CGF/HA). A review of the medical follow-up records of all patients was conducted, with a primary focus on the otoendoscopic imaging materials. Complete epithelialization was determined by the absence of granulation, discharge, and swelling. The requisite period for complete epithelialization of the mastoid cavity was thus calculated, scored, and analyzed between treatments. Results: Ear discharge, graft swelling, and poor blood supply were more frequently observed in the HA group. The proportion of patients group that achieved complete epithelialization within 60 days post operation was significantly higher in the CGF/HA group than the HA group. According to the scoring system for complete epithelialization, the median score of the CGF/HA group was 2, significantly higher than that of the HA treatment group (median score = 1, p = 0.032). Altogether, our results indicated that duration needed for complete epithelialization in the CGF/HA group was shorter than the control group. Conclusion: The application of CGF to surgical cavity obliteration following a CWD mastoidectomy significantly promotes epithelialization, thereby achieving satisfactory results. Randomized controlled trials with a larger number of patients enrolled were worth launching in the future to better substantiate the value of CGF in obliteration of mastoid cavity. Level of evidence: Level 2-Oxford Centre for Evidence-Based Medicine 2011 Levels of Evidence.http://www.sciencedirect.com/science/article/pii/S1808869425000047CholesteatomaMastoid reconstructionConcentrated growth factorMastoidectomyMastoid obliteration |
| spellingShingle | Mengyi Liu Lue Zhang Quanming Zhang Nan Zeng Shuo Li Shuyue Guo Yaqin Zhao Mingxing Tang Qiong Yang Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy Brazilian Journal of Otorhinolaryngology Cholesteatoma Mastoid reconstruction Concentrated growth factor Mastoidectomy Mastoid obliteration |
| title | Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy |
| title_full | Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy |
| title_fullStr | Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy |
| title_full_unstemmed | Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy |
| title_short | Concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy |
| title_sort | concentrated growth factors promote epithelization in the mastoid obliteration after canal wall down mastoidectomy |
| topic | Cholesteatoma Mastoid reconstruction Concentrated growth factor Mastoidectomy Mastoid obliteration |
| url | http://www.sciencedirect.com/science/article/pii/S1808869425000047 |
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