Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies
Abstract Background Cancer poses significant economic and societal burdens on countries in the coming decades. During chemotherapy, patients frequently encounter adverse reactions. Recent research has revealed that Chinese medicine plays a crucial role in mitigating the side effects of chemotherapy....
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Biological Procedures Online |
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| Online Access: | https://doi.org/10.1186/s12575-025-00264-7 |
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| author | Fang-Yuan Liu Xin Liu Dan-Ni Ding Shao-Xuan Liu Jing Xu Yu-Xin Zhao Yan-Hong Wang Feng-Juan Han |
| author_facet | Fang-Yuan Liu Xin Liu Dan-Ni Ding Shao-Xuan Liu Jing Xu Yu-Xin Zhao Yan-Hong Wang Feng-Juan Han |
| author_sort | Fang-Yuan Liu |
| collection | DOAJ |
| description | Abstract Background Cancer poses significant economic and societal burdens on countries in the coming decades. During chemotherapy, patients frequently encounter adverse reactions. Recent research has revealed that Chinese medicine plays a crucial role in mitigating the side effects of chemotherapy. Therefore, in this article, we propose that the cancer treatment process can be likened to an unequal game. To refine treatment strategies, we suggest employing the Steinberg model to incorporate Chinese medicine into the chemotherapy regimen for tumor treatment. Results We found that when malignant tumors exhibit vigorous proliferation, doctors should administer Chinese medicine in conjunction with chemotherapy drugs, continuously optimizing the therapeutic effect of the Chinese medicine. Upon reaching a specific threshold in the treatment effect of the Chinese medicine, doctors may appropriately augment the dosage of chemotherapy drugs, building upon the initial regimen. Conversely, in cases where the proliferation ability of malignant tumors is weak, the dosage of chemotherapy and the adjuvant therapy with Chinese medicine should be kept in a relatively balanced state. Once the effect of the Chinese medicine attains a particular threshold, the dosage of chemotherapy can be concurrently increased to achieve a superior therapeutic result. Conclusions From a game theory perspective, doctors can devise strategies to minimize drug toxicity and improve tumor treatment outcomes by coordinating the use of chemotherapy drugs with appropriate adjustments to Chinese medicine therapy methods. |
| format | Article |
| id | doaj-art-bcfcfe61bd4f4131b8969c0426406691 |
| institution | Kabale University |
| issn | 1480-9222 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Biological Procedures Online |
| spelling | doaj-art-bcfcfe61bd4f4131b8969c04264066912025-02-09T12:12:41ZengBMCBiological Procedures Online1480-92222025-02-012711710.1186/s12575-025-00264-7Optimizing the Future: A Game Theory to Tumor Therapeutic StrategiesFang-Yuan Liu0Xin Liu1Dan-Ni Ding2Shao-Xuan Liu3Jing Xu4Yu-Xin Zhao5Yan-Hong Wang6Feng-Juan Han7Heilongjiang University of Chinese MedicineHarbin Institute of TechnologyHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineHeilongjiang University of Chinese MedicineFirst Affiliated Hospital of Heilongjiang University of Chinese MedicineFirst Affiliated Hospital of Heilongjiang University of Chinese MedicineAbstract Background Cancer poses significant economic and societal burdens on countries in the coming decades. During chemotherapy, patients frequently encounter adverse reactions. Recent research has revealed that Chinese medicine plays a crucial role in mitigating the side effects of chemotherapy. Therefore, in this article, we propose that the cancer treatment process can be likened to an unequal game. To refine treatment strategies, we suggest employing the Steinberg model to incorporate Chinese medicine into the chemotherapy regimen for tumor treatment. Results We found that when malignant tumors exhibit vigorous proliferation, doctors should administer Chinese medicine in conjunction with chemotherapy drugs, continuously optimizing the therapeutic effect of the Chinese medicine. Upon reaching a specific threshold in the treatment effect of the Chinese medicine, doctors may appropriately augment the dosage of chemotherapy drugs, building upon the initial regimen. Conversely, in cases where the proliferation ability of malignant tumors is weak, the dosage of chemotherapy and the adjuvant therapy with Chinese medicine should be kept in a relatively balanced state. Once the effect of the Chinese medicine attains a particular threshold, the dosage of chemotherapy can be concurrently increased to achieve a superior therapeutic result. Conclusions From a game theory perspective, doctors can devise strategies to minimize drug toxicity and improve tumor treatment outcomes by coordinating the use of chemotherapy drugs with appropriate adjustments to Chinese medicine therapy methods.https://doi.org/10.1186/s12575-025-00264-7Game theoryChemotherapy drugsChinese medicineTumor therapeutic strategiesSteinberg game model |
| spellingShingle | Fang-Yuan Liu Xin Liu Dan-Ni Ding Shao-Xuan Liu Jing Xu Yu-Xin Zhao Yan-Hong Wang Feng-Juan Han Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies Biological Procedures Online Game theory Chemotherapy drugs Chinese medicine Tumor therapeutic strategies Steinberg game model |
| title | Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies |
| title_full | Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies |
| title_fullStr | Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies |
| title_full_unstemmed | Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies |
| title_short | Optimizing the Future: A Game Theory to Tumor Therapeutic Strategies |
| title_sort | optimizing the future a game theory to tumor therapeutic strategies |
| topic | Game theory Chemotherapy drugs Chinese medicine Tumor therapeutic strategies Steinberg game model |
| url | https://doi.org/10.1186/s12575-025-00264-7 |
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