The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries
The dental caries remains a globally prevalent disease. Although its incidence has decrease due to enhancements in sanitation policies and public health measures, the treatment and prevention of dental caries still pose significant challenges. Within the oral cavity, traditional drug delivery system...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1546816/full |
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| author | Han Du Zheng Wang Shenglan Long Yiding Li Deqin Yang Deqin Yang Deqin Yang |
| author_facet | Han Du Zheng Wang Shenglan Long Yiding Li Deqin Yang Deqin Yang Deqin Yang |
| author_sort | Han Du |
| collection | DOAJ |
| description | The dental caries remains a globally prevalent disease. Although its incidence has decrease due to enhancements in sanitation policies and public health measures, the treatment and prevention of dental caries still pose significant challenges. Within the oral cavity, traditional drug delivery systems suffer from limitation such as inadequate tissue penetration, short duration of action at target site, and low specificity, which minimally affect the prevention and treatment of dental caries. Consequently, nanosystem for drug delivery, offering enhanced drug stability, solubility, and bio-availability while reducing side effects, garnering attention increasing attention in the fight against dental caries. Therefore, this review examines the role of nanosystems for drug delivery in combating dental caries by inhibiting bacteria survival, biofilm formation, demineralization, and promoting remineralization, and exploring their potential to become the mainstream means of prevention and treatment of dental caries in future. |
| format | Article |
| id | doaj-art-be6f472bf1cb440990a25f7ee1e36ff7 |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-be6f472bf1cb440990a25f7ee1e36ff72025-02-11T07:00:10ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-02-011510.3389/fcimb.2025.15468161546816The advancement of nanosystems for drug delivery in the prevention and treatment of dental cariesHan Du0Zheng Wang1Shenglan Long2Yiding Li3Deqin Yang4Deqin Yang5Deqin Yang6Stomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing, ChinaStomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing, ChinaStomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing, ChinaStomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing, ChinaStomatological Hospital of Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases, Chongqing, ChinaDepartment of Conservative Dentistry and Endodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Craniomaxillofacial Development and Diseases, Fudan University, Shanghai, ChinaThe dental caries remains a globally prevalent disease. Although its incidence has decrease due to enhancements in sanitation policies and public health measures, the treatment and prevention of dental caries still pose significant challenges. Within the oral cavity, traditional drug delivery systems suffer from limitation such as inadequate tissue penetration, short duration of action at target site, and low specificity, which minimally affect the prevention and treatment of dental caries. Consequently, nanosystem for drug delivery, offering enhanced drug stability, solubility, and bio-availability while reducing side effects, garnering attention increasing attention in the fight against dental caries. Therefore, this review examines the role of nanosystems for drug delivery in combating dental caries by inhibiting bacteria survival, biofilm formation, demineralization, and promoting remineralization, and exploring their potential to become the mainstream means of prevention and treatment of dental caries in future.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1546816/fulldental cariesbiofilmnanosystems for drug deliveryremineralizationantibacterial agents |
| spellingShingle | Han Du Zheng Wang Shenglan Long Yiding Li Deqin Yang Deqin Yang Deqin Yang The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries Frontiers in Cellular and Infection Microbiology dental caries biofilm nanosystems for drug delivery remineralization antibacterial agents |
| title | The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries |
| title_full | The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries |
| title_fullStr | The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries |
| title_full_unstemmed | The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries |
| title_short | The advancement of nanosystems for drug delivery in the prevention and treatment of dental caries |
| title_sort | advancement of nanosystems for drug delivery in the prevention and treatment of dental caries |
| topic | dental caries biofilm nanosystems for drug delivery remineralization antibacterial agents |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1546816/full |
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