Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio)
Color vision, which is mediated by cone photoreceptors in vertebrates, is essential for perceiving the external environment. Bisphenol A (BPA) and its substitute bisphenol S (BPS) have been widely used worldwide, while the evaluation of their safety, especially the newly discovered visual toxicity m...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000739 |
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| author | Liguo Qiu Peng Yu Qiang Li Cuiping Wen Haiyang Wang Dongying Zhao Tianyu Zhang Chenghui Wang Lixia Liu Dongxue Li Shiyong Wen Yinghui Sun |
| author_facet | Liguo Qiu Peng Yu Qiang Li Cuiping Wen Haiyang Wang Dongying Zhao Tianyu Zhang Chenghui Wang Lixia Liu Dongxue Li Shiyong Wen Yinghui Sun |
| author_sort | Liguo Qiu |
| collection | DOAJ |
| description | Color vision, which is mediated by cone photoreceptors in vertebrates, is essential for perceiving the external environment. Bisphenol A (BPA) and its substitute bisphenol S (BPS) have been widely used worldwide, while the evaluation of their safety, especially the newly discovered visual toxicity mechanism caused by them in recent years, has not been clearly explored. In the present study, we investigated the effects of BPA treatment (1, 10, and 100 μg/L) on cone cell development and function to evaluate visual toxicity. We also compared the mechanisms of color deficiency induced by BPA and BPS at the same concentrations. The results indicated that BPA (10 and 100 μg/L) caused the abnormal proliferation (increased number of cone cells), morphological abnormalities (increased height of cone cells), mosaic pattern disorder, and depressed expression of key genes related to the photo-transduction pathway, and impaired the light perception ability of both red and UV cones ultimately. Similar to the BPA exposure group, BPS (1, 10, and 100 μg/L) exposure resulted in structural damage and mosaic arrays disorder of red and UV cone photoreceptors. In contrast to BPA exposure, BPS exposure resulted in significant activation of key genes involved in the phototransduction pathway. Our data indicate that both BPS and BPA exposure can interfere with the development of cone cells, and two types of compounds disturb the transduction of photon signals within cone cells in different ways, which further impaired the retinal spectral sensitivity to the light signal. This study clarifies the root cause for color vision impairment induced by BPA from the perspective of cone-mediated color vision. It also clarified that the BPA and its substitute BPS may not be entirely safe at the single-cell level. |
| format | Article |
| id | doaj-art-bf0f64b3ffd04b66b728f4468d523646 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-bf0f64b3ffd04b66b728f4468d5236462025-02-12T05:30:09ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117737Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio)Liguo Qiu0Peng Yu1Qiang Li2Cuiping Wen3Haiyang Wang4Dongying Zhao5Tianyu Zhang6Chenghui Wang7Lixia Liu8Dongxue Li9Shiyong Wen10Yinghui Sun11College of Life Sciences, Dezhou University, De’ zhou 253023, China; Corresponding authors.Dezhou Hospital, Qilu Hospital of Shandong University, Dezhou 253023, China; Corresponding authors.Jinan Ecological Environment Digital Application Center Lixia Branch, Jinan 250014, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, ChinaBelgorod College of Food Sciences, Dezhou University, Dezhou 253023, ChinaCollege of Agriculture and Biology, Liaocheng University, Liaocheng 252000, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, ChinaCollege of Life Sciences, Dezhou University, De’ zhou 253023, China; Correspondence to: No. 566 university Rd. West, Decheng District, Dezhou City, Shandong Province, China.Color vision, which is mediated by cone photoreceptors in vertebrates, is essential for perceiving the external environment. Bisphenol A (BPA) and its substitute bisphenol S (BPS) have been widely used worldwide, while the evaluation of their safety, especially the newly discovered visual toxicity mechanism caused by them in recent years, has not been clearly explored. In the present study, we investigated the effects of BPA treatment (1, 10, and 100 μg/L) on cone cell development and function to evaluate visual toxicity. We also compared the mechanisms of color deficiency induced by BPA and BPS at the same concentrations. The results indicated that BPA (10 and 100 μg/L) caused the abnormal proliferation (increased number of cone cells), morphological abnormalities (increased height of cone cells), mosaic pattern disorder, and depressed expression of key genes related to the photo-transduction pathway, and impaired the light perception ability of both red and UV cones ultimately. Similar to the BPA exposure group, BPS (1, 10, and 100 μg/L) exposure resulted in structural damage and mosaic arrays disorder of red and UV cone photoreceptors. In contrast to BPA exposure, BPS exposure resulted in significant activation of key genes involved in the phototransduction pathway. Our data indicate that both BPS and BPA exposure can interfere with the development of cone cells, and two types of compounds disturb the transduction of photon signals within cone cells in different ways, which further impaired the retinal spectral sensitivity to the light signal. This study clarifies the root cause for color vision impairment induced by BPA from the perspective of cone-mediated color vision. It also clarified that the BPA and its substitute BPS may not be entirely safe at the single-cell level.http://www.sciencedirect.com/science/article/pii/S0147651325000739Abnormal proliferationmorphological damagephotosensitive dysfunctionbisphenolscone cells |
| spellingShingle | Liguo Qiu Peng Yu Qiang Li Cuiping Wen Haiyang Wang Dongying Zhao Tianyu Zhang Chenghui Wang Lixia Liu Dongxue Li Shiyong Wen Yinghui Sun Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) Ecotoxicology and Environmental Safety Abnormal proliferation morphological damage photosensitive dysfunction bisphenols cone cells |
| title | Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) |
| title_full | Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) |
| title_fullStr | Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) |
| title_full_unstemmed | Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) |
| title_short | Comparative the effect of bisphenol A and bisphenol S on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae (Danio rerio) |
| title_sort | comparative the effect of bisphenol a and bisphenol s on the development and spectral sensitivity of cone photoreceptors in zebrafish larvae danio rerio |
| topic | Abnormal proliferation morphological damage photosensitive dysfunction bisphenols cone cells |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000739 |
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