Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances
Background: Alzheimer's disease (AD) is a significant and prevalent threat in the current period, with a dearth of accessible treatment options. There is an urgent need to identify novel molecular markers for the diagnosis and treatment of AD. Genetic biomarkers hold promising potential in this...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Phytomedicine Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031325000259 |
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| author | Mithila Debnath Mahir Azmal Rashid Taqui Moshiul Alam Mishu Ajit Ghosh |
| author_facet | Mithila Debnath Mahir Azmal Rashid Taqui Moshiul Alam Mishu Ajit Ghosh |
| author_sort | Mithila Debnath |
| collection | DOAJ |
| description | Background: Alzheimer's disease (AD) is a significant and prevalent threat in the current period, with a dearth of accessible treatment options. There is an urgent need to identify novel molecular markers for the diagnosis and treatment of AD. Genetic biomarkers hold promising potential in this regard. Purpose: The study aimed to adopt a new strategy to identify and characterize potential biomarkers and therapeutic phytochemicals for AD by integrating gene expression data and computational analysis. Methods: A differential expression analysis was conducted using GEO2R, where the significant differentially expressed genes (DEGs) were identified in brain areas that include the Entorhinal Cortex (EC) and Posterior Cingulate (PC), as well as in peripheral blood. The interactions between DEGs and phytochemicals were investigated using computational approaches that involve molecular docking and molecular dynamic simulations. Results: A total of 17 potential biomarkers including BAD, CDK5, FN1, ITGA4, and MAPK9 were identified. Quercetin and Berberine have shown significant binding affinities to these biomarkers according to molecular docking studies, indicating their potential as effective treatment agents. The ADME profile has shown the presence of favorable properties, specifically blood-brain barrier permeability. These findings suggest that the biomarkers found are implicated in important pathways associated with the development of AD and they emphasize the potential of Quercetin and Berberine as therapeutic agents. Conclusions: This study provides a thorough comprehension of the molecular basis of AD and proposes that Quercetin and Berberine have the potential as efficacious therapy options. This research provides a promising viewpoint on treatments for AD by focusing on proteins that are increased in certain parts of the brain, such as the EC and PC, which play a crucial role in the pathways leading to neurodegeneration. |
| format | Article |
| id | doaj-art-bf33f2f0fdf3460ca71a0ab71324c6c8 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-bf33f2f0fdf3460ca71a0ab71324c6c82025-02-10T04:35:25ZengElsevierPhytomedicine Plus2667-03132025-02-0151100752Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advancesMithila Debnath0Mahir Azmal1Rashid Taqui2Moshiul Alam Mishu3Ajit Ghosh4Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, BangladeshDepartment of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, BangladeshDepartment of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, BangladeshDepartment of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, BangladeshCorresponding author.; Department of Biochemistry and Molecular Biology, Shahjalal University of Science and Technology, Sylhet, 3114, BangladeshBackground: Alzheimer's disease (AD) is a significant and prevalent threat in the current period, with a dearth of accessible treatment options. There is an urgent need to identify novel molecular markers for the diagnosis and treatment of AD. Genetic biomarkers hold promising potential in this regard. Purpose: The study aimed to adopt a new strategy to identify and characterize potential biomarkers and therapeutic phytochemicals for AD by integrating gene expression data and computational analysis. Methods: A differential expression analysis was conducted using GEO2R, where the significant differentially expressed genes (DEGs) were identified in brain areas that include the Entorhinal Cortex (EC) and Posterior Cingulate (PC), as well as in peripheral blood. The interactions between DEGs and phytochemicals were investigated using computational approaches that involve molecular docking and molecular dynamic simulations. Results: A total of 17 potential biomarkers including BAD, CDK5, FN1, ITGA4, and MAPK9 were identified. Quercetin and Berberine have shown significant binding affinities to these biomarkers according to molecular docking studies, indicating their potential as effective treatment agents. The ADME profile has shown the presence of favorable properties, specifically blood-brain barrier permeability. These findings suggest that the biomarkers found are implicated in important pathways associated with the development of AD and they emphasize the potential of Quercetin and Berberine as therapeutic agents. Conclusions: This study provides a thorough comprehension of the molecular basis of AD and proposes that Quercetin and Berberine have the potential as efficacious therapy options. This research provides a promising viewpoint on treatments for AD by focusing on proteins that are increased in certain parts of the brain, such as the EC and PC, which play a crucial role in the pathways leading to neurodegeneration.http://www.sciencedirect.com/science/article/pii/S2667031325000259Alzheimer's diseaseBiomarkersDifferential gene expressionMolecular dynamic simulationQuercetin, Berberin, Neurodegeneration |
| spellingShingle | Mithila Debnath Mahir Azmal Rashid Taqui Moshiul Alam Mishu Ajit Ghosh Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances Phytomedicine Plus Alzheimer's disease Biomarkers Differential gene expression Molecular dynamic simulation Quercetin, Berberin, Neurodegeneration |
| title | Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances |
| title_full | Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances |
| title_fullStr | Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances |
| title_full_unstemmed | Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances |
| title_short | Biomarker discovery and phytochemical interventions in Alzheimer's disease: A path to therapeutic advances |
| title_sort | biomarker discovery and phytochemical interventions in alzheimer s disease a path to therapeutic advances |
| topic | Alzheimer's disease Biomarkers Differential gene expression Molecular dynamic simulation Quercetin, Berberin, Neurodegeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2667031325000259 |
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