Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation

Tumor-derived colorectal cancer organoids induce a unique Treg cell population by directing CD4+ T cell differentiation

Summary: In colorectal cancer (CRC), increased numbers of tumor-infiltrating CD4+ regulatory T (Treg) cells correlate with tumor development, immunotherapy failure, and poor prognosis. To assess how CRC tumors directly modulate Treg cell differentiation, we developed an in vitro co-culture system us...

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Bibliographic Details
Main Authors: Sonia Aristin Revilla, Cynthia L. Frederiks, Stefan Prekovic, Enric Mocholi, Onno Kranenburg, Paul J. Coffer
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:iScience
Subjects:
Immune response
Cancer
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225000872
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