New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease
The aim of review. To present up-to-date data on the causes of proton pump inhibitor-refractory gastroesophageal reflux disease (GERD) development.Summary. The prevalence of GERD reaches 20–30% of population, and approximately 40–50% of patients do not respond to standard treatment by proton pump in...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2014-11-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1133 |
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| author | Yu. V. Yevsyutina A. S. Trukhmanov |
| author_facet | Yu. V. Yevsyutina A. S. Trukhmanov |
| author_sort | Yu. V. Yevsyutina |
| collection | DOAJ |
| description | The aim of review. To present up-to-date data on the causes of proton pump inhibitor-refractory gastroesophageal reflux disease (GERD) development.Summary. The prevalence of GERD reaches 20–30% of population, and approximately 40–50% of patients do not respond to standard treatment by proton pump inhibitors (PPI). There is a disorder of the immune response as a disbalance between cellular and humoral components of immunity at GERD, that can be determined as phenotype of macrophages (М1 or М2), and other immune and non-immune cells.Conclusion. For the present moment it becomes clear, that low compliance of patients to PPI treatment, cytochrome Р450 isoenzyme CYP2C19 polymorphism and other known reasons are unable to explain growing number of refractory GERD cases. Therefore, studying of disease at cellular and tissue levels in relation to type of refluxate can disclose new mechanisms of refractory GERD and to increase treatment efficacy. |
| format | Article |
| id | doaj-art-c195990fa3aa4a69938abdf5c09cae2c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2014-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-c195990fa3aa4a69938abdf5c09cae2c2025-02-10T16:14:39ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732014-11-01245410733New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux diseaseYu. V. Yevsyutina0A. S. Trukhmanov1State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»State educational government-financed institution of higher professional education «Sechenov First Moscow state medical university»The aim of review. To present up-to-date data on the causes of proton pump inhibitor-refractory gastroesophageal reflux disease (GERD) development.Summary. The prevalence of GERD reaches 20–30% of population, and approximately 40–50% of patients do not respond to standard treatment by proton pump inhibitors (PPI). There is a disorder of the immune response as a disbalance between cellular and humoral components of immunity at GERD, that can be determined as phenotype of macrophages (М1 or М2), and other immune and non-immune cells.Conclusion. For the present moment it becomes clear, that low compliance of patients to PPI treatment, cytochrome Р450 isoenzyme CYP2C19 polymorphism and other known reasons are unable to explain growing number of refractory GERD cases. Therefore, studying of disease at cellular and tissue levels in relation to type of refluxate can disclose new mechanisms of refractory GERD and to increase treatment efficacy.https://www.gastro-j.ru/jour/article/view/1133refractory gastroesophageal reflux diseaseproton pump inhibitorscytokinesimmune response |
| spellingShingle | Yu. V. Yevsyutina A. S. Trukhmanov New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии refractory gastroesophageal reflux disease proton pump inhibitors cytokines immune response |
| title | New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease |
| title_full | New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease |
| title_fullStr | New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease |
| title_full_unstemmed | New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease |
| title_short | New opinion on the issue of proton pump inhibitor-refractory gastroesophageal reflux disease |
| title_sort | new opinion on the issue of proton pump inhibitor refractory gastroesophageal reflux disease |
| topic | refractory gastroesophageal reflux disease proton pump inhibitors cytokines immune response |
| url | https://www.gastro-j.ru/jour/article/view/1133 |
| work_keys_str_mv | AT yuvyevsyutina newopinionontheissueofprotonpumpinhibitorrefractorygastroesophagealrefluxdisease AT astrukhmanov newopinionontheissueofprotonpumpinhibitorrefractorygastroesophagealrefluxdisease |