A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting
Central Nervous System (CNS) disorders are the leading cause of illness and affect the everyday lives of people all around the globe and are predicted to increase tremendously in the upcoming decades. Traditional methods of delivering drugs to the CNS face considerable limitations. Nose-to-brain tar...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Designed Monomers and Polymers |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15685551.2025.2464132 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823858076570091520 |
|---|---|
| author | Naeem Mubarak Muhammad Ahsan Waqar Asad Majeed Khan Zainab Asif Aima Subia Alvi Aqsa Arshad Virk Sakeena Amir |
| author_facet | Naeem Mubarak Muhammad Ahsan Waqar Asad Majeed Khan Zainab Asif Aima Subia Alvi Aqsa Arshad Virk Sakeena Amir |
| author_sort | Naeem Mubarak |
| collection | DOAJ |
| description | Central Nervous System (CNS) disorders are the leading cause of illness and affect the everyday lives of people all around the globe and are predicted to increase tremendously in the upcoming decades. Traditional methods of delivering drugs to the CNS face considerable limitations. Nose-to-brain targeting offers a promising alternative that bypasses the blood-brain barrier (BBB), enabling targeted drug administration to the central nervous system (CNS). Nanotechnology has brought forward innovative solutions to the challenges of drug delivery in CNS disorders. Nanocarriers such as liposomes, nanoparticles, nanoemulsions and dendrimers can enhance drug stability, bioavailability, and targeted delivery to the brain. These nanocarriers are designed to overcome physiological barriers and provide controlled and sustained drug release directly to the CNS. Nanocarrier technology has made significant strides in recent years, enabling more effective and targeted delivery of drugs to the brain. With recent advancements, intranasal delivery coupled with nanocarriers seems to be a promising combination that can provide better clinical profiles, pharmacokinetics, and pharmacodynamics for neurodegenerative disorders. This study focuses on exploring the nose-to-brain drug delivery system, emphasizing the use of various nanocarriers designed for this purpose. Additionally, the study encompasses recent advancements in nanocarrier technology tailored specifically to improve the efficiency of drug administration through the nasal route to the brain. |
| format | Article |
| id | doaj-art-c3b2a01418794f7d9768fbff6e4d76b8 |
| institution | Kabale University |
| issn | 1385-772X 1568-5551 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Designed Monomers and Polymers |
| spelling | doaj-art-c3b2a01418794f7d9768fbff6e4d76b82025-02-11T15:10:11ZengTaylor & Francis GroupDesigned Monomers and Polymers1385-772X1568-55512025-12-0128172910.1080/15685551.2025.24641322464132A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targetingNaeem Mubarak0Muhammad Ahsan Waqar1Asad Majeed Khan2Zainab Asif3Aima Subia Alvi4Aqsa Arshad Virk5Sakeena Amir6Lahore University of Biological and Applied SciencesLahore University of Biological and Applied SciencesLahore University of Biological and Applied SciencesLahore University of Biological and Applied SciencesLahore University of Biological and Applied SciencesLahore University of Biological and Applied SciencesLahore University of Biological and Applied SciencesCentral Nervous System (CNS) disorders are the leading cause of illness and affect the everyday lives of people all around the globe and are predicted to increase tremendously in the upcoming decades. Traditional methods of delivering drugs to the CNS face considerable limitations. Nose-to-brain targeting offers a promising alternative that bypasses the blood-brain barrier (BBB), enabling targeted drug administration to the central nervous system (CNS). Nanotechnology has brought forward innovative solutions to the challenges of drug delivery in CNS disorders. Nanocarriers such as liposomes, nanoparticles, nanoemulsions and dendrimers can enhance drug stability, bioavailability, and targeted delivery to the brain. These nanocarriers are designed to overcome physiological barriers and provide controlled and sustained drug release directly to the CNS. Nanocarrier technology has made significant strides in recent years, enabling more effective and targeted delivery of drugs to the brain. With recent advancements, intranasal delivery coupled with nanocarriers seems to be a promising combination that can provide better clinical profiles, pharmacokinetics, and pharmacodynamics for neurodegenerative disorders. This study focuses on exploring the nose-to-brain drug delivery system, emphasizing the use of various nanocarriers designed for this purpose. Additionally, the study encompasses recent advancements in nanocarrier technology tailored specifically to improve the efficiency of drug administration through the nasal route to the brain.http://dx.doi.org/10.1080/15685551.2025.2464132central nervous systemnose-to-brainblood-brain barriernanotechnologynanocarrierspolymeric nanoparticles |
| spellingShingle | Naeem Mubarak Muhammad Ahsan Waqar Asad Majeed Khan Zainab Asif Aima Subia Alvi Aqsa Arshad Virk Sakeena Amir A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting Designed Monomers and Polymers central nervous system nose-to-brain blood-brain barrier nanotechnology nanocarriers polymeric nanoparticles |
| title | A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting |
| title_full | A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting |
| title_fullStr | A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting |
| title_full_unstemmed | A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting |
| title_short | A comprehensive insight of innovations and recent advancements in nanocarriers for nose-to-brain drug targeting |
| title_sort | comprehensive insight of innovations and recent advancements in nanocarriers for nose to brain drug targeting |
| topic | central nervous system nose-to-brain blood-brain barrier nanotechnology nanocarriers polymeric nanoparticles |
| url | http://dx.doi.org/10.1080/15685551.2025.2464132 |
| work_keys_str_mv | AT naeemmubarak acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT muhammadahsanwaqar acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT asadmajeedkhan acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT zainabasif acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT aimasubiaalvi acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT aqsaarshadvirk acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT sakeenaamir acomprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT naeemmubarak comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT muhammadahsanwaqar comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT asadmajeedkhan comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT zainabasif comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT aimasubiaalvi comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT aqsaarshadvirk comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting AT sakeenaamir comprehensiveinsightofinnovationsandrecentadvancementsinnanocarriersfornosetobraindrugtargeting |